Blood
Articles in this Issue
Comparative efficacy of TBI-based vs. non-TBI reduced toxicity conditioning regimens in adult ALL undergoing allogeneic HCT in CR1: Improved outcomes with TBI-based RTC and ATG/ptcy combination
Abstract Background: The optimal conditioning regimen for adult patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hemat...
Characteristics and prognostic significance of myelodysplastic syndrome (MDS)-related features in vexas syndrome
Abstract Background: VEXAS syndrome is an adult-onset autoinflammatory disease caused by somatic UBA1 mutations. Up to 50% of VEXAS meet WHO...
Genomic and transcriptomic landscape of extranodal marginal zone lymphoma
Abstract Marginal zone lymphoma (MZL) is an uncommon non-Hodgkin B-cell lymphoma accounting for 7-10% of lymphoma diagnoses. Extranodal MZL...
Demographic trends in Acute Myeloid Leukemia related mortality in the United States: A 25-year national analysis (1999 - 2023)
Abstract Introduction Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by clonal proliferation of abnorm...
Integrative single-cell multi-omic and functional profiling of human bone marrow regulatory T cells to enhance GVHD-preventive cell therapies
Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for a variety of malignant and non-malignant h...
Glofitamab in combination with CD19 CAR-T therapy for high-risk relapsed/refractory large B-cell lymphoma
Abstract Introduction Relapsed or refractory large B-cell lymphoma (r/r LBCL) is associated with poor prognosis, particularly among patients...
Longitudinal trends in vaccination and cancer screening engagement among patients with chronic lymphocytic leukemia: A prospective cohort study and quality improvement initiative (2019–2025)
Abstract Patients (pts) with CLL are at increased risk of infections and other cancers. However, the real-world uptake of vaccinations and c...
Incidence of thrombosis and bleeding in patients receiving CAR-T cell therapy: A multicentric retrospective analysis of the Canadian experience
Abstract Introduction: Autologous genetically modified T cells armed with CD19-targeting chimeric antigen receptors (CARs) have revolutioniz...
Fc engineering of CD9 antibodies overcomes platelet toxicity and preserves superior potency against refractory acute lymphoblastic leukemia
Abstract Introduction Advances in CD19/CD22-directed immunotherapies have revolutionized the treatment landscape of relapsed/refractory acut...
Pivekimab sunirinine (PVEK) combined with FLAG-IDA for medically fit adults with untreated adverse-risk Acute Myeloid Leukemia (AML) or other high-grade myeloid neoplasms (NCT06034470)
Abstract Background: The need for more effective therapies for adults with adverse-risk AML is unquestioned. We hypothesized that combining a...
Incorporation of 8Gy total body irradiation into reduced intensity conditioning does not improve allogeneic transplant outcomes for high-risk adult acute lymphoblastic leukemia: Results from the randomised prospective phase 2 UK multicentre ALL-RIC impact study
Abstract Background Allogeneic stem cell transplant (allo-SCT) remains an important curative therapeutic modality in adults with high risk A...
Chromatin remodeler SATB2 thorough Bmi1/PRC1 activity controls transformation and reprogramming of ph+ B-cell progenitors
Abstract B-cell progenitor acute lymphoblastic leukemia (B-ALL) remains a high-mortality malignancy (~40%), despite the advent of allogeneic...
Daratumumab can lead to long-lasting remissions in patients with refractory immune thrombocytopenia but with a high incidence of severe infections
Abstract Introduction Despite the increasing number of therapeutic options for immune thrombocytopenia (ITP), refractory disease remains an...
Patients with multiple myeloma and CKD: Should we really hold off on bispecific therapy in this subgroup?
Abstract Introduction: Bispecific therapy is a novel immunotherapy directed against dual targets to enhance anti-tumor r...
Axi-cel delivers similar outcomes regardless of ASCT-eligibility in second line R/R LBCL: Combined data from ZUMA-7 and ALYCANTE
Abstract Introduction ZUMA-7 (NCT03391466) and ALYCANTE (NCT04531046) evaluated axicabtagene ciloleucel (axi-cel), a chimeric antigen recepto...
Immune landscape characterization of relapsed/refractory B-cell lymphoma patients treated with CD19 CAR-T cell therapy
Abstract Introduction Despite remarkable improvements in the survival of relapsed/refractory B-cell lymphoma (R/R BCL) patients following ch...
Effects of serum vitamin d on platelet function in primary immune thrombocytopenia
Abstract Background Vitamin D (VD) deficiency (VDD) has been associated with autoimmune diseases, though its exact role is unclear. Consiste...
Maribavir for cytomegalovirus infections after hematopoietic stem cell transplantation: A real world comparative cohort study
Abstract Objective: To evaluate the real-world effectiveness and safety of maribavir for treating CMV infection in hematopoietic stem cell t...
The impact of hematopoietic cell transplantation on sickle cell hepatopathy and vice versa
Abstract Hepatic diseases affect approximately 10% of patients with sickle cell disease (SCD), encompassing a spectrum of acute and chronic...
Biomarkers of ineffective erythropoiesis in patients with sickle cell anemia, at baseline and while treated with hydroxyurea, in comparison to patients with other iron-loading red cell disorders
Abstract Introduction. Ineffective erythropoiesis (IE) is defined by disproportionate expansion of the erythroid precursors relative to the...
Follicular disorganization of the spleen in sickle cell disease identified by a convolutional neural network model
Abstract The spleen is the largest immune organ and is among the first to be functionally impaired in sickle cell disease (SCD). Histopathol...
Real-world incidence of cardiotoxicity and associated hospitalizations after CD19-directed CAR T-cell therapy in adults with B-cell malignancies
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has revolutionized survival outcomes for relapsed or refractory B-cell ma...
Mitapivat improves red blood cell integrity by reducing membrane ubiquitination accumulation
Abstract Background: The ubiquitin-proteasome system (UPS)is essential for maintaining red blood cell (RBC) membrane homeostasis by degradin...
This is a title in sentence case: Venetoclax-based regimens versus intensive chemotherapy in fit older adults with newly diagnosed acute myeloid leukemia (AML)：a multicenter, prospective, randomized phase II trial
Abstract Background: The rising incidence of AML in elderly patients poses significant challenges due to adverse biology and comorbidities....
Targeting metabolic vulnerabilities in Acute Myeloid Leukemia: Therapeutic potential of l-asparaginase and synergy with venetoclax
Abstract Recent advances in supportive care, measurable residual disease (MRD), and genomic based risk stratification have significantly imp...