Blood
Articles in this Issue
Characterization of NDMM patients treated with daratumumab, lenalidomide, bortezomib and dexamethasone who fail to achieve a VGPR or have early progression
Abstract INTRO In patients with newly diagnosed multiple myeloma (NDMM) four drug induction therapy is associated with improved outcomes with...
When supportive care backfires: G-CSF induced aortitis unmasked during routine adjuvant chemotherapy
Abstract Case Summary: In today's fast-paced oncology world, where patient volume is only increasing, the ability to recognize rare but seri...
Prognostic impact of transplant conditioning intensity (TCI) score and minimal identifiable disease (MID) in MDS: A multicenter trophy group study
Abstract Background: Due to the heterogeneity of myelodysplastic syndromes (MDS) and variations in patient characteristics, the optimal cond...
Outcomes for Medicaid recipients with multiple myeloma: A national retrospective trend analysis from 2015 to 2022
Abstract Introduction: Despite global decreases in overall cancer incidence, the incidence of multiple myeloma (MM) continues to increase at...
The ratio of post-infusion circulating PD-1+ CAR-T subsets to product PD-1+ CAR-T cells serves as a predictive biomarker for long-term disease control in CAR T-cell therapy for R/R B-cell lymphoma
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy has proven to be a standard of care (SOC) for patients with relapsed/ref...
Preclinical evaluation of macrophage reprogramming in treatment of CTCL
Abstract Introduction: Reprogramming tumor-supportive macrophages may have therapeutic utility in cutaneous T-cell lymphoma (CTCL) (Wu et al...
Predicting survival outcomes in CAR-t treated B-cell lymphoma by combining PET/CT imagingand clinical features
Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a transformative option for relapsed/refractory (R/R) B-...
Allogeneic hematopoietic cell transplantation for infantile osteopetrosis: High rates of sinusoidal obstruction syndrome/veno-occlusive disease and transplant-related morbidity
Abstract Introduction Osteopetrosis is a group of heterogeneous inherited disorders characterized by osteoclast dysfunction-driven dysregula...
Nemtabrutinib in participants with relapsed or refractory follicular lymphoma: Updated efficacy and safety from cohort g of the phase 2 bellwave-003 study
Abstract Introduction: Covalent Bruton tyrosine kinase inhibitors (BTKis) have shown clinical activity as monotherapy in relapsed or refracto...
CYP3A4 inhibitors (CYP3A4i) and myelosuppression in patients (Pts) with newly diagnosed mutant isocitrate dehydrogenase 1 (mIDH1) Acute Myeloid Leukemia (AML) in the phase 3 AGILE study
Abstract Introduction Ivosidenib (IVO) is an oral, targeted, small-molecule inhibitor of mIDH1 approved for the treatment of pts with mIDH1 A...
Socioeconomic inequalities and health-related quality of life profile of patients with Myelodysplastic Syndromes (MDS): Analysis of 504 patients with higher-risk MDS
Abstract Background Socioeconomic status (SES) is a known factor frequently associated with health-related quality of life (HRQoL) in oncolo...
Early vs late plasmapheresis in TTP: A u.s. national study on in-hospital mortality
Abstract Introduction Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy that re...
An evaluation of the relationship between abnormal myocardial perfusion and diastolic dysfunction in sickle cell disease using PET rest-stress myocardial perfusion imaging: Mypers
Abstract Background: The morbidity and mortality burden of cardiac complications, including diastolic dysfunction (DD), is significant in si...
N-glycosylation of monoclonal immunoglobulins across plasma cell dyscrasias in routine care: A cohort study using EXENT® mass spectrometry
Abstract Background: N-glycosylation of monoclonal immunoglobulin light chains is increasingly recognised as a potential...
Survival outcomes for newly diagnosed non-germinal center large B cell lymphoma patients treated with R-CHOP based on double expressor status and genomic features
Abstract Background Previous work has linked the inferior prognosis of patients with newly diagnosed large B cell lymphoma (LBCL) of activat...
Prognostic impact of specific IGHV rearrangements in younger untreated Mantle Cell Lymphoma patients is independent of p53 alterations and may be modified by ibrutinib-based regimens: Insights from the TRIANGLE trial within the MULTIPLY project
Abstract Introduction The TRIANGLE trial (Dreyling et al, Lancet 2024) compared three treatment arms in untreated, younger patients with man...
Real world experience with brecadd protocol as frontline therapy for patients with advanced stage classical Hodgkin lymphoma: A multicenter retrospective study
Abstract Introduction: Traditionally, the management of patients with advanced-stage classical Hodgkin lymphoma (cHL) re...
Utilization and outcomes of erythropoietin stimulating agents in sickle cell disease patient: A real world data analysis
Abstract Background: Sickle cell disease (SCD) is hereditary blood disorder leading to anemia, vaco-occlusive crises, organ damage. Its trea...
Cytotoxic CD8⁺ T cells are required for CD20xCD3 bispecific antibody-mediated tumor control in B-cell non-Hodgkin lymphomas
Abstract Background: CD20xCD3 bispecific antibodies (BsAb) are a transformative therapy for B-cell non-Hodgkin lymphomas (B-NHL), effective...
Transplantation in combination with CAR T-cell therapy for refractory/relapsed aggressive B-cell lymphoma after failure of CD19 CAR-T cell therapy
Abstract Background: The prognosis for patients with refractory/relapsed aggressive B-cell lymphoma (R/R B-NHL) who have failed CD19 CAR-T c...
Diffuse large B cell lymphoma: A study of second primary malignancies among adults in the United States
Abstract Background: Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-hodgkin lymphoma (NHL), accounting for up to 30...
TP53 aberrant Mantle Cell Lymphoma treated with first-line systemic therapy: A real-world analysis of outcomes in 120 patients treated in the United Kingdom
Abstract Background: Alterations to the tumor suppressorTP53 in mantle cell lymphoma (MCL) are one of the strongest predictors of poor respo...
Dose dense rituximab for high-risk children and adolescents with newly diagnosed acute immune thrombocytopenic purpura (ITP) (NCT04323748)
Abstract Background: Immune thrombocytopenic purpura (ITP) is an immune-mediated bleeding disorder, occurring mainly in young children, with...
Predicting donor engraftment success in adults post haploidentical bone marrow transplant for sickle cell disease: BMT CTN 1507
Abstract Introduction: Hematopoietic Cell Transplant (HCT) using a HLA-haploidentical donor greatly expands access to cu...
Beyond the trial: Real-world CRS, icans, and healthcare burden of CAR T-cell therapy across US oncology practices
Abstract Background:Chimeric antigen receptor T-cell therapy (CAR T) has improved outcomes in relapsed/refractory diffuse large B-cell lymph...