Blood
Articles in this Issue
Patients with immune thrombocytopenia and antiplatelet antibodies show increased platelet activation and desialylation
Abstract Background Antiplatelet autoantibodies contribute to ITP pathogenesis by enhancing platelet clearance through multiple mechanisms....
Factors associated with remote healthcare utilization in MM patients undergoing autologous stem cell transplantation
Abstract Introduction: High-dose melphalan followed by autologous stem cell transplantation (HDM/ASCT) remains a cornerstone of multiple mye...
Liquid-biopsy mutation landscape and its concordance with skin biopsies in cutaneous T-cell lymphoma
Abstract Introduction: Liquid biopsy (LBx) is widely utilized for clinical evaluation and therapeutic monitoring in solid and hematologic ma...
CXCR4 antagonism reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia.
Abstract CXCR4 Antagonism Reduces Pneumonia Severity in a Pharmacological Mouse Model of CXCR2 Loss-of-Function-Mediated Neutropenia Robert...
Efficacy of erythropoietin and intravenous iron for treatment of critical anemia in patients who decline blood transfusions for religious reasons
Abstract Background: Severe anemia is a common medical emergency causing impaired oxygen delivery to vital tissues and organs. Prompt recogn...
Cladribine, idarubicin, and AraC (CLIA) combined with a FLT3 inhibitor in patients with newly diagnosed FLT3-mutated Acute Myeloid Leukemia: A pooled analysis of prospective trials
Abstract Introduction The incorporation of FLT3 inhibitors, cladribine, and high-dose cytarabine have been shown to improve outcomes in pts...
Efficacy and safety of low-dose vs. standard-dose direct oral anticoagulants for secondary prevention of venous thromboembolism: A systematic review and meta-analysis
Abstract Introduction: Extended anticoagulation therapy is recommended for patients with venous thromboembolism (VTE) at high risk of recurr...
Systemic mastocytosis with associated lymphoid neoplasms (SM-ALN): A distinct subset with indolent clinical course and favorable outcomes
Abstract Background: The coexistence of systemic mastocytosis (SM) and lymphoid neoplasms is rare and remains poorly def...
The efficacy and safety of homoharringtonine combined with venetoclax and azacitidine in primary refractory and relapsed/refractory acute myeloid leukemia
Abstract Background: Primary refractory and relapsed/refractory acute myeloid leukemia (AML) are associated with dismal outcomes, posing gre...
HDAC and CDK inhibitor combinations suppress neutrophil activation in myeloma
Abstract Neutrophils foster a pro-tumorigenic microenvironment in multiple myeloma (MM) by releasing inflammatory cytokines, immunosuppressi...
Image-based classification of lymphocyte subsets from routine blood smears reveals distinct immune dynamics after CAR-T infusion
Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy is an established treatment for hematological malig...
Central nervous system involvement in Mantle Cell Lymphoma: A retrospective multicenter cohort study from the spanish geltamo group
Abstract Background: Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) is an uncommon but clinically significant event,...
Impact of sociodemographic factors on survival outcomes in chronic myeloid leukemia in the United States: A time-trend analysis
Abstract Introduction: Chronic myeloid leukemia (CML) is a clonal stem cell malignancy defined by the BCR::ABL1 fusion. Although outcomes in...
Mosunetuzumab with response-driven lenalidomide augmentation achieves high response rates and immune reprogramming in untreated follicular and marginal zone lymphoma: A multicenter Phase 2 trial
Abstract Background:Mosunetuzumab (Mosun) is a CD20xCD3 bispecific antibody with high efficacy in treatment of relapsed/refractory follicula...
Trends in death from multiple myeloma with concomitant diabetes mellitus in the USA
Abstract Background Multiple myeloma (MM) is a cancer of plasma cells that accounts for about 10% of all hematologic cancers. With the globa...
The 10-minute targeted geriatric assessment (10-TaGA), a 10-domain-to-one-score tool, predicts early death in intensively treated older AML patients: First results from a multicenter study
Abstract Background: Older patients with acute myeloid leukemia (AML) are a particularly difficult-to-treat population, owing to the higher...
Bilateral optic nerve infiltration in pediatric ACUTE promyelocytic leukemia: A RARE and aggressive CNS relapse with probable ATRA resistance
Abstract Optic nerve leukemic infiltration is an exceptionally rare manifestation of acute promyelocytic leukemia (APL, AML-M3), especially...
Incidence and clinical outcomes of hematologic immune-related toxicities in patients with solid malignancies treated with immune checkpoint inhibitors
Abstract Introduction Immune checkpoint inhibitors (ICIs) are antineoplastic agents that mediate anticancer effects by u...
Distinct immune profiles among patients with primary effusion lymphoma and other kaposi sarcoma herpesvirus-associated diseases
Abstract Introduction Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), causes Kaposi sarcoma (KS), multicentric...
U.S. mortality trends in acquired aplastic anemia, 1999–2021: A joinpoint analysis using CDC wonder data
Abstract Background Acquired aplastic anemia (AAA) is an immune-mediated marrow failure syndrome with high early mortality. Survival has imp...
Multiomic correlates of ex vivo αCD19 chimeric antigen receptor T-cell (CART) cytotoxicity in venetoclax-treated patients with chronic lymphocytic leukemia (CLL)
Abstract Introduction: Chronic Lymphocytic Leukemia (CLL) results in the expansion of immunosuppressive B-cells leading...
Golidocitinib-based therapy in relapsed/refractory mycosis fungoides and Sézary syndrome: A real-world retrospective analysis
Abstract Cutaneous T-cell lymphoma (CTCL) is an incurable malignancy of skin-tropic malignant CD4+ T cells, with mycosis fungoides (MF; indo...
Real-world treatment patterns and biomarker utilization among patients aged ≥65 years with CLL/SLL from 2020 to 2024
Abstract Background Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common leukemia in US adults and incidence...
Roginolisib (IOA-244), an orally bioavailable, selective PI3Kδ inhibitor, in combination with venetoclax and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL)
Abstract Background and Significance Preclinical work established the synergy of BCL-2 inhibitors with phosphoinositide 3-kinase (PI3K) inhib...
Subcutaneous cevostamab demonstrates manageable safety and clinically meaningful activity in Relapsed/Refractory multiple myeloma (RRMM): First results from the Phase Ib CAMMA 3 study
Abstract Background: Fc receptor-homolog 5 (FcRH5) is a type I membrane protein that is ubiquitously expressed on multiple myeloma (MM) cell...