Blood
Articles in this Issue
Cost-effectiveness analysis of mosunetuzumab compared with novel alternative immunotherapies in patients with third-line or later relapsed/refractory follicular lymphoma in Japan
Abstract INTRODUCTION Follicular lymphoma (FL), a common indolent non-Hodgkin's lymphoma (NHL), accounts for approximately 10-20% of all NHLs...
Integrative omics analysis of TP53 in multiple myeloma patients
Abstract Introduction: Although TP53 gene alterations—such as 17p deletion and TP53 mutations—occur at relatively low fr...
Early life anthropometrics predict anthropometrics later in children with sickle cell disease and are different from the general population
Abstract Background: There is conflicting data on the effects of sickle cell disease (SCD) on anthropometrics. While some studies report tha...
FCR-I/iven combination for CLL: «Cheap but fierce»
Abstract Introduction. In the CLL8 trial for treatment-naïve patients with CLL, the FCR group had a PFS of 56.8 months compared with 32.9 mo...
Real-world study of population pharmacokinetic-guided pdVWF/FVIII (1:1) prophylaxis in people with severe von Willebrand disease: The PopPK-WILPROPHY study
Abstract Introduction: Prophylaxis with a von Willebrand factor (VWF)-containing concentrate is recommended for individuals with von Willebr...
Maternal and fetal pharmacokinetics (PK) of pegcetacoplan in paroxysmal nocturnal hemoglobinuria (PNH): A case report of use in pregnancy
Abstract Background: PNH is a rare, life-threatening hematologic disorder that poses significant risks in pregnancy. Pegcetacoplan, a first-i...
Preliminary efficacy and safety of the Bruton tyrosine kinase degrader BGB-16673 in patients with relapsed/refractory Richter transformation: Results from the ongoing phase 1 CaDAnCe-101 study
Abstract Introduction: There is no standard of care treatment for Richter transformation (RT) of chronic lymphocytic leukemia/small lymphocyt...
Relapsed/Refractory Hodgkin lymphoma after first-line escalated beacopdac: Adverse outcomes are overcome by use of second-line targeted therapy - an international real-world analysis
Abstract Introduction Escalated (e) BEACOPP is a well-established treatment option for advanced and intermediate-stage Hodgkin Lymphoma (HL)....
Evaluating the risk of non-melanoma skin cancer in patients with porphyria cutanea tarda: A retrospective cohort study using real-world data
Abstract Porphyrias are a group of disorders caused by disruptions in heme biosynthesis, each leading to accumulation of distinct porphyrin...
Trials in progress - a Phase Ib trial of epcoritamab in combination with ibrutinib in relapsed or refractory central nervous system lymphoma (EIFEL)
Abstract Background: Primary central nervous system lymphomas (PCNSL) is an aggressive subtype of diffuse large B-cell lymphoma with poor ou...
Letermovir primary prophylaxis is associated with reduced and delayed CMV reactivation in haploidentical allohct using ptcy.
Abstract Background: The use of letermovir (LTV) in the allogeneic hematopoietic cell transplant has dramatically changed the incidence of c...
Endothelial activation and stress index EASIX and it's variants as a prognostic marker for cytokine release syndrome in CAR-T cell therapy recipients: A systematic review and meta analysis
Abstract INTRODUCTION Background: Chimeric antigen receptor (CAR) T-cell therapy, while being efficacious for haematological malignancies, is...
Comparable efficacy of CR, CRh, and CRi in pediatric acute myeloid leukemia: A report from the Japan Children's Cancer Group
Abstract Introduction: The 2022 European Leukemia Network (ELN) recommendations defined several efficacy endpoints for acute myeloid leukemi...
Impact of adenovirus infection on the long-term cardiovascular and other outcomes following CAR T-cell therapy: A propensity-matched cohort study
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematologic malignancies but is asso...
Gender disparities in first-author representation across ASH submissions 2019-2024
Abstract Background: Achieving gender equity in academic hematology requires a multifaceted approach across all presentation types and resea...
Patients with Relapsed/Refractory multiple myeloma who achieved sustained minimal residual disease negativity in the dreamm-7 trial
Abstract Introduction: In the phase 3 DREAMM-7 trial (NCT04246047), belantamab mafodotin (belamaf) plus bortezomib and dexamethasone (BVd) d...
Benchmark evaluation of large language models in acute myeloid leukemia prognosis
Abstract Background: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy requiring accurate prediction of treatment response a...
CD19 expression is preserved following CD19-directed monoclonal antibody therapy with tafasitamab
Abstract Background: The availability of multiple CD19-targeted agents of different drug classes allows for sequential targeting of the CD19...
Effect of exercise on body composition and bone health in patients with thalassemia
Abstract Study Rationale: Over half of all adults with thalassemia (Thal) have low bone mass, bone pain and are at significant risk for frac...
Non-response to rituximab during immune thrombocytopenia is associated with more differentiated circulating B cells and CD8 T cells
Abstract Introduction. Immune thrombocytopenia (ITP) is a rare, acquired autoimmune disorder characterized by isolated thrombocytopenia with...
Real-world comparison of CAR T-cell therapy versus bispecific antibodies in relapsed or refractory multiple myeloma
Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies have emerged as transformative options for pa...
A novel reduce toxity myeloablative conditioning regimen f-BMT improves efficacy and safety of allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent thalassemia: A multicenter clinical trial
Abstract Background Conditioning regimens are crucial in allogeneic hematopoietic stem cell transplantation (allo-HSCT), especially for olde...
Trial in progress: Efficacy and safety of givinostat versus hydroxyurea in patients with polycythemia vera (GIV-IN-PV)
Abstract Background: Polycythemia vera (PV) is a BCR-ABL1-negative myeloproliferative neoplasm (MPN) characterized by excessive proliferation...
Exploring the immunodynamic landscape of blinatumomab therapy in pediatric BCP-ALL through full-spectrum flow cytometry
Abstract Background B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in children. Blinatumomab is a bis...
PTP4A3: A potential therapeutic target in Acute Myeloid Leukemia
Abstract Protein tyrosine phosphatase 4A3 (PTP4A3), a member of the protein tyrosine phosphatase family, regulates intracellular signaling b...