Blood
Articles in this Issue
Generating ectopic subcutaneous bone marrow by reconstitution of endochondral ossification
Abstract 【Introduction】 Bone and marrow formation occur concurrently during endochondral ossification in most bones, e...
Ensuring equitable access to bispecific antibodies in multiple myeloma: Findings from the emmbrace patient and public involvement and engagement (PPIE) sessions.
Abstract Background: Bispecific antibodies (BsAbs) are effective treatments for relapsed/refractory multiple myeloma (RRMM), but uptake rema...
Targeting hells‑mediated chromatin accessibility to sensitize ALK‑negative anaplastic large cell lymphoma to JAK/STAT and DNA‑PK inhibition
Abstract Chromatin remodelers regulate DNA-nucleosome interactions, influencing chromatin structure, accessibility, and gene expression (Gou...
Impact of helicobacter pylori infection on clinical outcomes in patients with immune thrombocytopenia: A propensity-matched analysis from a national cohort
Abstract Backgorund Over the past two decades, numerous international studies have explored a potential link between Hel...
Mapping genomic responses to kit receptor tyrosine kinase signaling in erythroid progenitors
Abstract Chromatin signatures at cis-regulatory elements can predict how they regulate transcription. However, accurate cell type-specific p...
Favorable impact of patient's selection on outcome of Relapsed/Refractory multiple myeloma treated with idecabtagene vicleucel (Ide-cel) chimeric antigen receptor (CAR) T-cell therapy; Experience in french patients (Super-FENIX): An IFM study from the descar-T registry
Abstract Idecabtagene vicleucel (Ide-cel) is the first chimeric antigen receptor (CAR) T-cell therapy targeting the B-cell maturation antige...
Real-world study of treatment landscape and safety outcomes of US patients with blastic plasmacytoid dendritic cell neoplasm
Abstract Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and clinically aggressive hematological malignancy, with...
Results of the first Latin American point of care manufactured, Phase I anti- CD19 CAR-T study (CARTHIAE) for Relapsed/Refractory B-cell neoplasms
Abstract Introduction: Chimeric Antigen Receptor (CAR) T-cell therapy targeting CD19 has demonstrated high efficacy in relapsed/refractory (...
Engineered biomimetic platelet membrane-coated nanoparticles as platelet decoys to reduce coagulopathy and improve outcomes in sepsis
Abstract Introduction: Platelets (plt) play crucial roles not only in hemostasis but also in immune defense. Thrombocytopenia is common in s...
Lipid nanoparticle-mediated mRNA transfection enables efficient and safe generation of CAR macrophages.
Abstract With the development of Chimeric Antigen Receptor (CAR) T-cells and its subsequent clinical trials and FDA approval, CAR T-cells ha...
Transcriptomic subclasses of KMT2A and NUP98 gene fusions in adolescent and adult Acute Myeloid Leukemia
Abstract KMT2A and NUP98 gene fusions are two common types of acute myeloid leukemia (AML) with poor prognosis, incorporated as independent e...
Plek2 as a novel downstream effector of p53: Targeting Plek2 ameliorates disease progression in p53-deficient myeloid malignancies
Abstract TP53 mutations are common in myeloid malignancies and are associated with poor prognosis and therapeutic resistance. However, the d...
Eravacycline in allogeneic stem cell transplant recipients: A real-world study of drug-drug interactions with cyclosporine/tacrolimus and anti-infective efficacy
Abstract Objective: Calcineurin inhibitors (CNIs) are standard prophylaxis for acute graft-versus-host disease (aGVHD) after allogeneic hema...
Disease-specific safety and efficacy of doacs vs. LMWH for venous thromboembolism in patients with brain metastases: A real-world trinetx analysis
Abstract Background: Determining the optimal anticoagulation strategy for venous thromboembolism (VTE) in patients with brain metastases rem...
Discrimination of Epstein–Barr virus latent infection and lytic replication reactivation using a novel methyl-CRISPR biosensor
Abstract Introduction: Epstein–Barr virus (EBV), the first identified human oncogenic gamma-herpesvirus, establishes lif...
Real-world poor prognostic impact of del(1p32) in newly diagnosed multiple myeloma among Asian populations
Abstract Background: Emerging evidence suggests that 1p32 deletion (del(1p32)) may represent an independent high-risk fa...
Prospective evaluation of venetoclax combined with CLAG regimen in relapsed/refractory acute myeloid leukemia: A multicenter, randomized controlled, open-lable, phase II Trial
Abstract CLAG (cladribine + cytarabine + G-CSF) based regimen is recommended for the salvage treatment of relapsed/refractory (RR) acute mye...
Improved health-related quality of life (HRQoL) and bleeding scores with oral bruton tyrosine kinase (BTK) inhibitor rilzabrutinib in the open-label (OL) period of the multicenter Phase 3 LUNA3 study in adults with immune thrombocytopenia (ITP)
Abstract Introduction Rilzabrutinib, a BTK inhibitor that acts through multi-immune modulation, showed rapid and durable platelet response,...
Results of a registrational Phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with Relapsed/Refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis)
Abstract Introduction BCL-2 inhibitors play an important role in the treatment of CLL/SLL. Although venetoclax monotherapy is approved (ex-C...
Evaluation of prognostic factors and survival outcomes in patients with Relapsed/Refractory (R/R) large B-cell lymphomas (LBCLs) treated with epcoritamab
Abstract Introduction: Epcoritamab (epco) is a bispecific antibody (BsAb) that is FDA approved for patients (pts) with R/R LBCLs based on the...
Prognostic significance of clinical risk models and genomic alterations in Waldenström macroglobulinemia before or after BTK inhibitor era
Abstract Background Waldenström's macroglobulinemia (WM) is an indolent B-cell lymphoma with high heterogeneity. Several clinical risk models...
Novel single red blood cell lifespan measurement assay through glycated hemoglobin assessment by flow cytometry
Abstract Introduction: Hemolysis is defined as an imbalance between the rate of red blood cell (RBC) production and destruction, leading to...
Correlation between treatment-emergent cytopenias and clinical response with imetelstat (IME) in patients (Pts) with lower-risk myelodysplastic syndromes (LR-MDS): Analysis from the imerge Trial
Abstract Introduction: IME is a first-in-class, direct, and competitive telomerase inhibitor approved for the treatment (tx) of certain adul...
Diagnostic accuracy of PET/CT scan in differentiating malignant and bland thrombi in cancer patients: A systematic review
Abstract Introduction: Differentiating between tumor thrombus and bland thrombus can be challenging, however it is of paramount importance a...
Effectiveness of polatuzumab-based regimens among elderly patients with previously untreated diffuse large B-cell lymphoma: A systematic review and meta-analysis
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and disprop...