Blood
Articles in this Issue
Distinct immune checkpoint landscapes in PCNSL and SCNSL revealed by single-nucleus profiling
Abstract Introduction Primary central nervous system lymphoma (PCNSL) is a rare and aggressive subtype of diffuse large B-cell lymphoma (DLB...
Advantages of less frequent doing of BCMA-directed bispecific antibodies
Abstract The use of bispecific antibodies to treat relapsed/refractory myeloma has increased dramatically over the past several years. The r...
Defining resistance: Clinical outcomes based on varying definitions of heparin resistance
Abstract Introduction: Heparin resistance refers to the need for higher doses of unfractionated heparin to achieve therapeutic anticoagulati...
Unifying the classification of acute myeloid leukemia, myelodysplasia-related: A multi-institutional experience
Abstract WHO5th and ICC2022 include AML myelodysplasia-related (AML-MR) as a new diagnostic entity that incorporates the mutation profile, r...
The fast off-rate of anito-cel's D-Domain binder contributes to its distinctive pharmacology profile in preclinical models of multiple myeloma
Abstract Introduction: B cell maturation antigen (BCMA) directed CAR T-cell therapies have transformed the multiple myeloma (MM) treatment l...
Policy and systems solutions to expand timely access to CAR T-cell therapy: Findings from a national survey of oncology professionals
Abstract Background: CAR T-cell (CAR T) therapy offers the potential for durable remission and improved survival for patients with hematolog...
Health status of Ugandan children born with sickle cell anemia and congenital HIV identified through newborn screening
Abstract Introduction. In 2014-2015, the Uganda Sickle Surveillance Study (US3) tested almost 100,000 dried blood spots that were originally...
High-resolution detection of structural variants in cancer cell lines using electronic genome mapping
Abstract Introduction: Structural variants (SVs) are often associated with adverse outcomes in hematologic malignancies,...
Rising mortality and burden of multiple myeloma in adolescents and young adults: A sex and income-stratified global analysis, 1990–2021
Abstract Background: Multiple myeloma, traditionally considered a disease of older adults, is increasingly recognized among adolescent and y...
Prevalence, treatment patterns, and complications of sickle cell disease in insured US populations: A retrospective study
Abstract Introduction: Sickle cell disease (SCD), a genetic blood disorder, is characterized by significant acute and chronic complications,...
Histone acetyltransferase p300/CBP as a therapeutic target to ameliorate gvhd-induced inflammatory memory
Abstract Background: Recently, emerging evidence indicated that inflammation-induced epigenetic remodeling in tissue stem cells enhances eit...
Feasibility, outcomes and challenges of CAR-T cell therapy as advanced or earlier line of treatment for B-cell non-Hodgkin lymphomas: A multicenter national study
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy has transformed the therapeutic landscape of refractory B-cell non-Hodg...
Single-cell sequencing of bone marrow cells and peripheral mononuclear cells reveals immune features of paraneoplastic pemphigus in a FL patient
Abstract Objective：To elucidate the cellular and molecular mechanisms underlying paraneoplastic pemphigus (PNP), a fatal autoimmune blister...
Promote-FL: Pirtobrutinib and mosunetuzumab to enhance treatment efficacy for patients with relapsed/refractory follicular lymphoma
Abstract Background: Bispecific T cell engagers have been approved to treat relapsed/refractory (r/r) follicular lymphoma (FL) after two pri...
Quantifying disparity: Race, socioeconomic status, and survival disparities in AML
Abstract Background: Acute Myeloid Leukemia (AML) outcomes are shaped by far more factors than disease biology perse. Other factors includin...
ANKRD26-related thrombocytopenia: Hematologic malignancy characteristics, clinical outcomes, and precursor states
Abstract Introduction Heterozygous germline pathogenic variants (PVs) in the 5' untranslated region of ANKRD26 cause inherited thrombocytope...
An explosive onset: Tumor lysis syndrome in newly diagnosed Mantle Cell Lymphoma.
Abstract An Explosive Onset: Tumor lysis syndrome in Newly diagnosed Mantle cell Lymphoma. Introduction:...
Short-term follow-up results of ultra-low-dose radiotherapy for indolent B-cell lymphoma
Abstract Objective: To evaluate the short-term efficacy and safety of ultra-low-dose radiotherapy (4 Gy) in patients with indolent B-cell ly...
NB02 (Poseltinib) combined rituximab and lenalidomide in R/ R PCNSL (POTENTIAL-P): Initial results of safety lead-in cohort.
Abstract Background: Primary central nervous system lymphoma (PCNSL) is a rare, highly aggressive B-cell non-Hodgkin lymphoma confined to th...
Mechanistic insights into how g protein-coupled receptor kinases (GRKs) regulate thrombopoiesis
Abstract Platelet disorders encompass abnormalities in platelet function as well as alterations in platelet counts, including thrombocytopen...
Longitudinal single-cell spatial proteomics reveals predictive immune and stem cell signatures in Relapsed/Refractory AML
Abstract Relapsed/refractory (R/R) acute myeloid leukemia (AML) remains a major clinical challenge, particularly in patients previously expo...
Clinical study reveals the high efficacy and well-tolerance of venetoclax combined with homoharringtonine, azacitidine, and cytarabine in newly diagnosed AML
Abstract Background Venetoclax, a B-cell lymphoma 2 inhibitor, has achieved encouraging outcomes in the treatment of acute myeloid leukemia...
A novel BCL-2 inhibitor, bda-366, targets the TLR4 pathway to induce leukemic cell differentiation in venetoclax-resistant RAS-mutated monocytic leukemia
Abstract Introduction Although venetoclax (VEN) combined with hypomethylating agents exhibits significant therapeutic efficacy in acute myel...
Circulating tumor plasma cells as an independent prognostic marker in newly diagnosed multiple myeloma: Clinical correlation and immunophenotypic insights
Abstract Introduction Circulating tumor plasma cells (CTPCs) reflect the dissemination potential of malignant clones in...
Trial in progress: Multi-center clinical trial to replace BM analysis of cytopenia with a peripheral blood assay
Abstract Background and significance Indications for cytopenia range from simple reversible causes to serious disorders like myelodysplastic...