Blood
Articles in this Issue
Aplastic anemia and substance use: National trends and associations in the United States from 1999-2023- a CDC wonder analysis
Abstract Background: In recent years, aplastic anemia has emerged as a life-threatening disease, with known links to certain medications and...
Younger donors, better outcomes: The impact of donor age in haploidentical transplantation for acute myeloid leukemia. study conducted on behalf of geth-TC
Abstract INTRODUCTION Haploidentical hematopoietic cell transplantation (haplo-HCT) using post-transplant cyclophosphami...
The clinical observation of treating autoimmune cytopenias after allogeneic hematopoietic stem cell transplantation in children by immunoinduction therapy
Abstract This retrospective study explored safety and efficacy of immunoinduction methods such as Immunosuppressants are reduced and discont...
Belumosudil is effective in patients with chronic graft-versus-host disease lasting more than two years: A retrospective single-center real-world study
Abstract Background: As for chronic graft-versus-host disease (cGVHD), treatment options beyond traditional strategies remain limited. Belum...
Pharmacologic drugging of BCL-2 during manufacturing restores T cell fitness and enhances CART efficacy
Abstract While originally developed to induce cancer cell apoptosis, venetoclax, the most clinically relevant BH3-mimetic targeting the anti...
Real-world thrombotic and survival outcomes with erythropoiesis-stimulating agents in cancer-related anemia: A propensity-matched cohort Study
Abstract Background: Erythropoiesis stimulating agents (ESAs) are frequently used to manage cancer related anemia by increasing hemoglobin le...
Mesenchymal stem cells for treating gastrointestinal-involved steroid-refractory acute graft-versus-host disease: A multicenter, single-arm, pivotal clinical Trial
Abstract Background: Steroid-refractory acute graft-versus-host disease (SR-aGVHD) is the predominant cause of morbidity and mortality after...
Pathogenesis on dysregulated blood glucose homeostasis in severe hand-foot-mouth disease mouse model
Abstract Background Hand, foot, and mouth disease (HFMD) is a common infectious disease among children under five years old, with large-scal...
Mapping out the impact of MAP kinase in primary myelofibrosis
Abstract Introduction Primary myelofibrosis (MF) is a genetically diverse myeloproliferative neoplasm (MPN) that is often driven by somatic m...
Mecom gene network drives chemotherapy resistance in high-risk acute myeloid leukemia
Abstract Background: Despite recent advances in targeted chemotherapies for acute myeloid leukemia (AML), treatment of relapsed and refractor...
Multilayer profiling of MRD in patients with relapsed/refractory CLL treated with venetoclax-based regimens in a real-world setting
Abstract Background Undetectable minimal residual disease (uMRD) is a strong prognostic factor for progression-free survival (PFS) in venetoc...
primary analysis of the smart stop trial: Lenalidomide, tafasitamab, rituximab, and acalabrutinib alone and with combination chemotherapy in newly diagnosed diffuse large B-cell lymphoma
Abstract Background: First-line therapy for newly diagnosed large B-cell lymphoma (LBCL) has remained chemotherapy-based for nearly five dec...
Venetoclax plus inotuzumab ozogamicin for relapsed and refractory ALL: Results of a phase I trial
Abstract Introduction: Inotuzumab ozogamicin (INO), an anti-CD22 antibody-drug conjugate, can induce a complete remission (CR) in >80...
Phase I study of NPB5005-V283 in patients with relapsed/refractory multiple myeloma
Abstract Background: Chimeric antigen receptor (CAR)-T cell therapies have produced durable antitumor response for the treatment of relapsed...
Automated classification of acute lymphoblastic leukemia in peripheral blood smears using a convoluted neural network, ResNet18 model
Abstract Background Acute lymphoblastic leukemia (ALL) is the most prevalent malignancy in children and remains a therapeutic challenge in a...
Real-world insights into multiple myeloma management: An analysis of EHR-derived data in the UK and Germany
Abstract Background: Multiple myeloma (MM) is a heterogeneous hematologic malignancy with significant variability in treatment approaches ac...
Comparison of PICC lines vs. tunneled catheters (Hickman/Portacaths) in stem cell transplantation: A 4 year retrospective analysis of infection rates, complications, and cost-effectiveness
Abstract Background: Central venous catheters (CVCs) are essential for stem cell transplantation (SCT), with tunnelled c...
Glucocorticoid metabolizing enzymes predict initial glucocorticoid sensitivity in childhood ALL
Abstract Introduction Synthetic glucocorticoids (GC) are crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). The...
Cytokine signatures in immune thrombocytopenia across clinical stages
Abstract Immune Thrombocytopenia (ITP) is an autoimmune disorder marked by decreased platelet counts due to accelerated destruction and/or i...
Sickle cell disease trials redefined: Toward unified clinical endpoints through international consensus
Abstract Introduction Despite significant progress in the treatment of sickle cell disease (SCD), many clinical trials (especially recent ph...
Supportive care alone is effective for managing low-grade CRS in multiple myeloma patients treated with bispecific antibodies
Abstract Introduction: Patients with relapsed/refractory multiple myeloma (RRMM) who receive BCMA or GPRC5D-directed bispecific antibodies (...
Toward ‘n of one’ gene therapies: Scalable ex vivo adenine base editing via lipid nanoparticles in a sickle cell disease model
Abstract Sickle cell disease (SCD) affects millions globally and results from a β-globin gene mutation causing abnormal hemoglobin and rigid...
Stroke in adults with sickle cell disease: Outcomes of a non-HbS-targeted combined hydroxyurea and manual exchange transfusion strategy
Abstract Background: Ischemic stroke is a serious complication of sickle cell disease (SCD). While most secondary prev...
Feasibility and acceptability of point of care lung ultrasound for identification of acute chest syndrome in an inpatient pediatric hematology unit
Abstract Background: Acute chest syndrome (ACS) is a potentially life-threatening complication of sickle cell disease (SCD). Diagnosis is cu...
Efficacy and safety of zanubrutinib, rituximab, and venetoclax combination regimen in previously untreated follicular lymphoma: A Phase II trial from the bbc study
Abstract Background: Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma. BCL-2 protein overexpression is observed in...