Blood
Articles in this Issue
Sf3b1+/K700E hematopoietic stem cells create their own expansion niche
Abstract Myelodysplastic syndromes (MDS) is an heterogenous group of clonal hematopoietic disorders that affect older individuals. It is cha...
Safety and feasibility of outpatient myeloablative total marrow and lymphoid Irradiation–based allogeneic transplantation in adults with high-risk acute lymphoblastic leukemia
Abstract Background Myeloablative total body irradiation (TBI) has long been a fundamental part of conditioning regimens...
Transcriptomic and pathological insights into PI3K–Akt pathway activation in idiopathic multicentric castleman disease, tafro and NOS subtypes
Abstract Introduction: Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder character...
Trial in progress: Study design of a randomized, phase 3 trial evaluating the efficacy and safety of mezagitamab (TAK-079) compared with placebo in adults with chronic primary immune thrombocytopenia
Abstract Background and significance: Immune thrombocytopenia (ITP) is a rare autoimmune bleeding disorder characterized by severe thrombocy...
Association of delayed platelet recovery and lower nadir counts with adverse outcomes in heparin-induced thrombocytopenia
Abstract Introduction: Heparin-induced thrombocytopenia (HIT) is a rare, life-threatening prothrombotic disorder triggered by exposure to he...
Impact of chronic pain on acute pain trajectories in sickle cell disease: Insights from the sickle cell disease treatment with arginine therapy (STArT) randomized controlled trial
Abstract Background/Methods: STArT (NCT04839354) was a phase-3 double-blind, randomized placebo-controlled trial of intravenous (IV) arginin...
Single-cell RNA-sequencing of cerebrospinal fluid reveals transcriptional divergence of leukemia cells from bone marrow in pediatric B-ALL
Abstract Central nervous system (CNS) relapse of B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, is associate...
Cytogenetic subgroup analysis of the advance trial: A randomized multi-center study of carfilzomib, lenalidomide and dexamethasone (KRd) with or without daratumumab (D) in patients with newly diagnosed multiple myeloma (NDMM)
Abstract Introduction: Cytogenetic abnormalities such as del(17p), t(4;14), and gain(1q), among others and particularly when co-occurring, a...
Efficacy and safety of peginterferon alfa-2b for chronic myeloid leukemia and essential thrombocythemia during pregnancy
Abstract Background Myeloproliferative neoplasms during pregnancy increase the risk of maternal complications (including...
Metabolomic dynamics of cytokine release syndrome in CD19 CAR-T therapy
Abstract Purpose: Cytokine release syndrome (CRS) after CD19 CAR-T therapy poses a significant risk of morbidity and stands as a formidable...
The variable splicing factor RBM17 regulates MDS cell proliferation through H3K27la
Abstract Myelodysplastic syndrome is characterized by reduced production of all three lineages of blood cells, primarily affecting elderly i...
ICAM-2 mediates adhesion of acute myeloid leukemia cells to bone marrow microenvironment and promotes chemoresistance
Abstract Abstract Introduction: Relapse and drug resistance of acute myeloid leukemia (AML) are the main challenges in clinical treatment, a...
Early and safe administration of G-CSF in AML patients treated with venetoclax-based therpy: Clinical and molecular insights from a single czech center
Abstract Introduction: This analysis evaluates the impact of early administration of the growth factor G-CSF during the...
Remodeling the bone marrow tumor microenvironment with CART cell therapy to overcome resistance in multiple myeloma
Abstract B cell maturation antigen (BCMA)-targeted chimeric antigen receptor T (CART) cell therapies have emerged as a potentially curative...
Procedure-triggered late-onset congenital thrombotic thrombocytopenic purpura: Unmasking functional impact of a heterozygous synonymous ADAMTS13 variant (c.1716G>A) associated with reduced enzyme expression
Abstract Background: Congenital thrombotic thrombocytopenic purpura (cTTP), also known as Upshaw–Schulman syndrome, is a...
A large language model-based framework for automated phenotypic characterization in myeloproliferative neoplasms
Abstract Background Accurate diagnosis and risk stratification in myeloproliferative neoplasms (MPNs) rely on expert interpretation of compl...
CRE intestinal colonization correlates with increased progression risk following CAR T cell therapy in relapsed/refractory lymphoma
Abstract Introduction The rate of carbapenem-resistant Enterobacteriaceae (CRE) detection in hematology-oncology units h...
Longitudinal immune reconstitution dynamics in refractory T-ALL treated with CD7 CAR-T cells bridging to allogeneic stem cell transplantation
Abstract Introduction T-cell acute lymphoblastic leukemia (T-ALL) is associated with a poor prognosis, with 20–30% of ad...
Comparative analysis of next generation flow (NGF) and next generation sequencing based clonoseq for MRD detection in multiple myeloma using paired bone marrow samples
Abstract Background: Minimal residual disease (MRD) is a critical prognostic and therapeutic response marker in multiple myeloma (MM). Two ma...
Lessons learned from the clinical trial portfolio of ixazomib in multiple myeloma: A systematic review and meta-analysis
Abstract Introduction: Ixazomib is a next-in-class oral proteasome inhibitor approved for relapsed multiple myeloma (MM). However, it has fa...
Radiotherapy of extramedullary acute myeloid leukemias overcomes resistance to checkpoint blockade that is enhanced by natural killer cell depletion
Abstract Introduction: Immune checkpoint inhibitors have been relatively ineffective in acute myeloid leukemias (AML), likely due to immune...
Deciphering the dilemma: Intravenous (IV) iron use in iron deficiency anemia during acute infections
Abstract Background The use of intravenous (IV) iron for treating iron deficiency anemia during acute infections remains...
Piezo1 is essential for endothelial-to-hematopoietic transition and hematopoietic stem/progenitor cell generation during embryonic development
Abstract Introduction Hematopoietic stem cells (HSCs) form the basis of the hematopoietic system, with essential functions including long-te...
Molecular distinctiveness of duodenal-type follicular lymphoma revealed by integrated multi-omic analysis
Abstract Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma, typically presenting with widespread nodal involv...
Real-world outcomes of teclistamab in triple-exposed relapsed/refractory multiple myeloma: Brazilian single-center experience
Abstract Background: Teclistamab is a B-cell maturation antigen (BCMA)-targeting bispecific T-cell engager approved for commercialization in...