Blood
Articles in this Issue
CAR-T efficacy in large B-cell lymphoma is shaped by neoantigen-driven epitope spreading and limited by HLA loss and genomic instability
Abstract INTRODUCTION CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) has revolutionized large B cell lymphoma (LBCL) treatme...
Dose modifications of mezigdomide when coadministered with CYP3A4 inhibitors for patients with relapsed/refractory multiple myeloma
Abstract Introduction: Mezigdomide (MEZI), an oral CELMoD™ agent with potent antimyeloma and immunostimulatory effects, has demonstrated enc...
Epidemiology of refractory thrombocytopenia: A retrospective overview of SEER database
Abstract Background: Immune Thrombocytopenia (ITP) is defined as immune mediated destruction of platelets. Refractory Thrombocytopenia (RT)...
Safety and efficacy of CD19/CD22/CD20 multi-targeted CAR-T therapy in patients with refractory/relapsed B-cell non-Hodgkin lymphoma
Abstract Background CAR-T therapy has significantly improved response rates in refractory/relapsed B-cell non-Hodgkin lymphoma (R/R B-NHL). H...
Gut microbiota and metabolomic profiling in Relapsed/Refractory lymphoma
Abstract Gut Microbiota and Metabolomic Profiling in Relapsed/Refractory Lymphoma Objective: The gut microbiota, as a crucial component of t...
Overcoming leukemia stem cells via targeting AKT-wnt/β-catenin by AI-powered mRNA-delivery of peptides
Abstract Leukemia stem cells (LSCs) are key drivers of chemoradiotherapy resistance, immune evasion, and frequent relapse of leukemia. Despi...
Venetoclax combined with cacag regimen as a bridge to allogeneic hematopoietic stem cell transplantation in patients with previously untreated acute myeloid leukemia achieving CR1
Abstract Abstract Objective: To analyze the impact of venetoclax (VEN) combined with the CACAG induction regimen on 1-year relapse in previo...
Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation
Abstract INTRODUCTION. Germinal center (GC) lymphomas, including follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), arise f...
Impact of apheresis-to-infusion interval on outcomes and toxicity of CAR-T therapy in relapsed/refractory DLBCL
Abstract Background: Chimeric antigen receptor (CAR)-T cell therapy is a transformative treatment for patients with relapsed/refractory diff...
Anti-CD19 chimeric antigen receptor T-cells therapy (CAR-T) is effective in secondary cns lymphoma (SCNSL) refractory to high-dose methotrexate (HDMTX)-based chemotherapy
Abstract Introduction: Secondary involvement of the CNS is a direful complication of large B cell lymphomas (LBCL), which can occur at diagn...
Interpreting tryptase levels and avoiding common pitfalls in screening for clonal mast cell disease
Abstract Introduction: Clonal mast cell diseases (cMCD) are driven by clonal expansion of aberrant mast cells (MC), primarily due to the gai...
Phenotypic spectrum and treatment outcomes in Russian gaucher disease patients: Real-world experience with biosimilar imiglucerase
Abstract Background Gaucher disease (GD), the most prevalent lysosomal storage disorder, manifests with cytopenia, organomegaly, and skeleta...
A quality improvement project to improve the delivery rate of IV iron to patients admitted with severe gastrointestinal hemorrhage
Abstract Background: The most common cause of Iron Deficiency (ID) in men and post-menopausal women is gastrointestinal (GI) bleeding. Despi...
Multiomic signatures of durable response in a Phase I/II trial of tandem aCD22-aCD19 CAR-T therapy for relapsed B-lineage acute lymphoblastic leukaemia
Abstract Background: CAR-T therapeutic failures are multifactorial and include a lack of cell proliferation post-infusion, reduced effector...
An analysis of the mutational landscape of Acute Myeloid Leukemia at an urban tertiary care center: A retrospective cohort study
Abstract Background: Acute Myeloid Leukemia (AML) is an aggressive malignancy accounting for 1% of adult cancers and 2% of cancer deaths in...
Conditional progression free survival (PFS) in patients with multiple myeloma (MM) after upfront autologous stem cell transplantation (ASCT): A secondary CIBMTR analysis
Abstract Background: Progression-free survival (PFS) with upfront (1L) multiple myeloma (MM) therapy measures time from diagnosis to progres...
A matching-adjusted indirect comparison (MAIC) of zanubrutinib vs venetoclax + ibrutinib in treatment-naive chronic lymphocytic leukemia (CLL)
Abstract Introduction: Zanubrutinib is a selective next-generation Bruton tyrosine kinase (BTK) inhibitor approved for the treatment of CLL....
Comparative analysis of fatal serious adverse events associated with FDA-approved bispecific antibodies in hematologic malignancies
Abstract Background: Bispecific T-cell engagers (BiTEs) and bispecific antibodies (BiAbs) have transformed the treatment landscape of hemato...
Humanistic and economic burden among caregivers of adults and children with transfusion dependent β-thalassemia
Abstract Introduction: Transfusion-dependent β-thalassemia (TDT) is a chronic, inherited blood disorder characterized by chronic anemia requ...
Analysis of growth, development and endocrine function in children with primary immunodeficiency disease after hematopoietic stem cell transplantation
Abstract Objective ：To analyze the growth, development and endocrine function of children with primary immunodeficiency disease after hemat...
Incidence and impact of non-traumatic intracranial hemorrhage on outcomes in chimeric antigen receptor T-cell therapy: Insights from a six-year nationwide analysis
Abstract Background Chimeric Antigen Receptor (CAR) T-cell therapy is a transformative treatment for relapsed or refract...
Investigating belumosudil in children with refractory moderate-to-severe chronic graft-versus-host disease: Design of a phase 1/2 study
Abstract Background: Chronic graft-versus-host disease (cGvHD) is a significant complication in children who have underg...
Chronic alcohol consumption epigenetically reactivates transposable elements in aged hematopoietic stem cells
Abstract Transposable elements (TEs) are mobile repetitive DNA sequences capable of jumping across the genome. After birth, TEs are epigenet...
Impact of NPM1 co-mutation on outcomes in RAS-mutated Acute Myeloid Leukemia
Abstract Introduction: Oncogenic Mutations in RAS, most commonly involving NRAS and KRAS, occur in 10–25% of cases of ac...
Cardiovascular safety profile of CD20 × CD3 bispecific antibodies compared to immune-checkpoint inhibitors: A faers analysis, 2014–2025
Abstract Background: Bispecific T-cell engagers (BTEs) have evolved from CD19 × CD3 constructs such as blinatumomab to newer CD20 × CD3 agen...