Blood
Articles in this Issue
Uncovering practice gaps in the management of mantle cell and diffuse large B-cell lymphomas amidst advances with Bruton's tyrosine kinase inhibitors
Abstract BACKGROUND: Mantle cell lymphoma (MCL) and diffuse large B-cell lymphoma (DLBCL) are two of the most diagnosed subtypes of B-cell n...
The predictive value of the interleukin 2 receptor (IL2)/ferritin ratio in the diagnosis of lymphoma associated hemophagocytic lymphohistiocytosis (LAHS): A United States, multi center experience
Abstract Introduction Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory syndrome that can occur de novo or due...
Gene Expression–Based prediction of 1q, 1p, 13q, and 17p chromosome ploidy in newly diagnosed and paired relapsed myeloma and across the plasma cell dyscrasia spectrum
Abstract Gene Expression–Based Prediction of 1q, 1p, 13q, and 17p Chromosome Ploidy in Serial Newly Diagnosed and Relapsed Myeloma and Acros...
Transfusion burden among older US patients with relapsed FLT3-mutated Acute Myeloid Leukemia treated with gilteritinib: A Medicare claims-based cohort study
Abstract Background : Older patients with relapsed acute myeloid leukemia (AML) often require transfusion support due to persistent cytopeni...
A phase 2 clinical study on intensifying idarubicin dosage for inducing remission in acute myeloid leukemia patients aged 65 and younger
Abstract Introduction: Until now, the standard induction therapy for acute myeloid leukemia (AML) has been a continuous infusion of cytarabi...
The surpass trial: a phase 2/3 registrational trial of ELA026 in subjects with treatment-Naïve secondary hemophagocytic lymphohistiocytosis
Abstract Background/Significance: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory condition wher...
Prognostic value of mayo 2012 vs. european‑modified mayo 2004 staging in AL amyloidosis patients with discordant stage classifications
Abstract Background: Systemic AL amyloidosis is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin li...
Reassessing voxelotor safety and efficacy: Real-world outcomes from the ASH research collaborative data hub
Abstract Voxelotor binds the α-globin subunit of HbS, stabilizing it in the oxygenated state, which may reduce polymerization. Voxelotor was...
Real-world data on cardiovascular disease incidence in adults with acquired immune aplastic anemia.
Abstract Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure with a high propensity for clonal hematopoiesis (CH), where...
Thrombotic thrombocytopenic purpura with features of evans syndrome in a case of lupus vasculitis
Abstract Introduction: Thrombotic thrombocytopenic purpura (TTP), distinguished by severe ADAMTS13 deficiency, is an emergency requiring imm...
Overall survival after post-transplant cyclophosphamide (PTCy) peripheral blood hematopoietic cell transplantation (HCT) differs by race, ethnicity, and donor
Abstract Introduction Hispanic and non-Hispanic Black (NHB) patients have worse HCT survival compared to non-Hispanic White (NHW) patients a...
Allogeneic transplantation and frontline therapy shape survival outcomes in secondary AML: Real-world epidemiology and prognostic insights
Abstract Background: Secondary acute myeloid leukemia (sAML) continues to be associated with poor prognosis. Identification of subgroups wit...
Delayed pulmonary embolism following oocyte retrieval in invitro fertilization: A neglected risk factor for thromboembolic events?
Abstract Introduction: Pulmonary embolism (PE) is a rare complication that is often underdiagnosed following assisted reproductive technolog...
Association between increased Patients' out-of-pocket costs for apixaban and oral anticoagulant discontinuation in high-risk patients with atrial fibrillation - a retrospective Medicare claims study
Abstract Introduction: Atrial fibrillation (AF) affects millions of adults in the United States and is a major risk fact...
Comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus belantamab mafodotin (belamaf), bortezomib, and dexamethasone and versus belamaf, pomalidomide, and dexamethasone in patients with relapsed / refractory multiple myeloma (RRMM) previously treated with 1–3 prior lines of therapy using a matching-adjusted indirect comparison
Abstract Introduction: The CARTITUDE-4 (NCT04181827) trial compared cilta-cel, a chimeric antigen receptor (CAR)-T cell treatment (tx) target...
Impacts of IPSS-m and conditioning intensity in allogeneic hematopoietic cell transplant for patients with myelodysplasia neoplasms
Abstract Introduction: Allogeneic hematopoietic cell transplantation (allo-HCT) is the only curative treatment for patients with myelodyspla...
Clinical NGS detection of TP53 mutations in chronic phase primary myelofibrosis: Comparative analyses of genotype and prognosis
Abstract Background A previous multicenter study of patients with TP53-mutated myeloproliferative neoplasms showed a significantly shorter su...
Real-world safety of sutimlimab in patients with CAD/CAS: A multinational, multi-center, observational, prospective cohort Study
Abstract Background: Cold agglutinin disease (CAD) and cold agglutinin syndrome (CAS) are cold antibody driven autoimmune hemolytic anemias,...
Intein-based modular assembly of multi-receptor CAR T cells
Abstract Background: Chimeric antigen receptor (CAR) T cells demonstrate strong antitumor activity. However, therapeutic success is often li...
Haploidentical donor regulatory T cells and memory T cells are safe and effective in children with refractory graft-versus-host disease with concurrent viral infections
Abstract Background: Graft-versus-host disease (GVHD) refractory to immunosuppressive therapy (IST) remains a major complication following a...
Efficacy of short-course versus standard-course blinatumomab in patients with relapsed/refractory or MRD-positive B-cell acute lymphoblastic leukemia
Abstract Introduction Blinatumomab, a bispecific antibody targeting CD3/CD19, can significantly improve the complete remission (CR) rate, me...
A retrospective analysis of the safety and effectiveness of recombinant von willebrand factor in children with von willebrand disease undergoing surgery
Abstract Background: Von Willebrand disease (VWD) is a bleeding disorder caused by deficient or defective von Willebrand factor (VWF) that c...
The first program for local CD19-CAR-T production and treatment of lymphoma in the UAE update median 1 year follow up and CART cell persistence
Abstract Introduction: CD19 CART cell therapy has emerged as an effective treatment option for many patient with Relapsed/Refractory None Hod...
Dioscin suppresses the progression of diffuse large B-cell lymphoma by modulating acaca-dependent histone H3K27 acetylation and inducing mitophagy
Abstract Dioscin is a natural steroidal saponin from traditional Chinese medicine with known antitumor properties and clinical applications...
Clinician-assessed eastern cooperative oncology group performance status vs. patient-reported health-related quality of life: Insights from malignant lymphoma
Abstract Background: The patient-reported health-related quality-of-life (HRQoL) is an important indicator for measuring the clinical outcom...