Blood
Articles in this Issue
Impact of prior B-cell-directed immunotherapy on the outcome of CD19 CAR T-cell therapy in aggressive B-cell lymphoma - an analysis of the EBMT and the GoCART coalition
Abstract Introduction: Treatment outcomes of diffuse large B-cell lymphoma (DLBCL) and related large B-cell lymphoma (LB...
Real-world safety profile of PD-1 inhibitors in Epstein–Barr Virus–Associated lymphoproliferative disorders: A retrospective analysis from west China hospital
Abstract Background PD-1 inhibitors are increasingly utilized beyond oncology, including in Epstein-Barr virus–associated hemophagocytic lym...
Treatment landscape and outcome of myeloproliferative neoplasms in asia: Interim analysis of the Asian myeloproliferative neoplasm registry
Abstract Background Large multicenter analysis of myeloproliferative neoplasms (MPNs) has not been conducted in Asia. Ai...
Golidocitinib combined with CHOP in treatment-Naïve monomorphic epitheliotropic intestinal T-cell lymphoma: Preliminary results from A phase 2 multicenter, single-arm goal study
Abstract Background Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and highly aggressive subtype of peripheral T-ce...
Efficacy and safety of brentuximab vedotin versus standard therapy for cutaneous T-cell lymphoma: A systematic review and meta-analysis
Abstract Introduction: Cutaneous T-cell lymphoma (CTCL) is an uncommon form of non-Hodgkin lymphoma. It is often untreatable, particularly a...
Efficacy, safety, and T-cell population dynamics of glofitamab monotherapy in relapsed/refractory B-cell lymphoma
Abstract Purpose Patients with relapsed/refractory (R/R) B-cell lymphoma (BCL) have a poor prognosis. We evaluated the efficacy, adverse eve...
Hemorrhage and thrombosis in adult patients with acute lymphoblastic leukemia: A comparative analysis between conventional vs pediatric-inspired induction regimens
Abstract Introduction: Acute lymphoblastic leukemia (ALL) in adults poses unique challenges, particularly during induction therapy. Differen...
Persistent symptom burden and unmet needs in long-term survivors of allogeneic hematopoietic cell transplantation: An analysis using the MD anderson symptom inventory (MDASI-BMT)
Abstract Background: Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for many hematologic malignancies, yet surviv...
Sickle cell disease in the global south: Mapping the unmet burden using global burden of disease DALY estimates and its relevance to United States hematologists
Abstract Sickle cell disease (SCD) affects approximately 7.74 million people globally as of 2021, with nearly 80% residing in sub-Saharan Af...
Oncodif: An auditable AI framework for automated genomic curation and natural-language clinical querying in hematologic malignancies
Abstract Background Precision treatment in hematologic malignancies relies on rapid, accurate interpretation of tumor ge...
Survival outcomes and treatment patterns in primary and secondary plasma cell leukemia: A multicenter retrospective cohort study
Abstract Background: Plasma Cell Leukemia (PCL) is a rare and highly aggressive plasma cell disorder, typically categorized into primary Plas...
Long-term follow-up of venetoclax therapy in AL amyloidosis
Abstract Background: The t(11;14) translocation occurs in 50–60% of patients with systemic AL amyloidosis. Venetoclax, an oral BCL-2 inhibit...
CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric b ALL
Abstract Introduction: The 4-year disease-free survival (DFS) of children with first isolated central nervous system (iCNS) relapse treated...
IVIG prevents infections without affecting mortality in DLBCL patients treated with CAR T-cell or bispecific antibody therapy: A real-world propensity-matched study
Abstract Background Chimeric antigen receptor T-cell (CAR T) therapy and bispecific antibodies (BSAB) have transformed the treatment of rela...
CRLF2 expression and MRD kinetics outcomes across the age spectrum in Mexican patients with acute lymphoblastic leukemia: Prevalence and association with post-induction measurable residual disease
Abstract Introduction CRLF2 gene rearrangements are the most common genetic alteration in Philadelphia chromosome-like (...
A multi-institutional machine-learning score that predicts bacteremia and gram class at blood-culture initiation
Abstract Bacteremia is a clinically significant condition due to its potential to rapidly progress to sepsis, a life-threatening complicatio...
Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study
Abstract Background: Acute myeloid leukemia (AML) is a genetically heterogeneous hematological malignancy. Risk stratification in AML is prim...
Dynamic machine Learning–Based prediction of major bleeding in patients receiving anticoagulant therapy: A multi-center study
Abstract Background: Oral anticoagulants are increasingly prescribed for atrial fibrillation, venous thromboembolism (VTE), arterial thrombo...
Temporal assessment of phenotype and receptor profile of in vitro expanded healthy natural killer cells using irradiated feeder cells
Abstract Allogeneic natural killer (NK) cell therapy is an emerging approach in treating hematological malignancies. NK cells recognize tumo...
Analysis of cardiovascular risk factors in a cohort of patients with ITP in a tertiary care center
Abstract INTRODUCTION There is a higher risk of thrombosis in ITP compared to general population, but little is known ab...
Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Abstract Background Acute graft-versus-host disease (aGVHD) is a significant cause of morbidity and mortality in patients undergoing allogen...
Targeted long-read sequencing with adaptive sampling in multiple myeloma: A pilot study toward a unified diagnostic platform
Abstract INTRODUCTION Multiple Myeloma (MM) is a genetically complex blood cancer marked by diverse mutations, structural rearrangements, an...
First-in-human trial of allogeneic CD6-CAR tregs in patients with chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation
Abstract Chronic graft-versus-host disease (cGVHD) remains the leading cause of late nonrelapse mortality and morbidities affecting quality...
Lipid deregulation impacts hematopoietic stem cell functions during aging
Abstract Hematopoietic Stem Cells (HSC) have high regenerative potential to sustain the production of blood throughout life. This property a...
Cardioembolic stroke in children and young adults: Comprehensive management and risk of hemorrhagic transformation-a single institutional experience
Abstract Background: Cardio-Embolic stroke affects up to 8 percent of children with congenital heart disease. Pediatric stroke guidelines re...