Blood
Articles in this Issue
Evaluating bone marrow sample quality derived using a non-redirection versus a traditional bone marrow aspiration and biopsy technique
Abstract Background:The traditional bone marrow aspiration and biopsy technique involves the insertion of the biopsy needle once to obtain a...
In-hospital stroke, myocardial infarction, and venous thrombosis in immune thrombocytopenia: Incidence, risk factors, and outcomes from a national cohort
Abstract Background: Immune Thrombocytopenia (ITP) is paradoxically associated with an increased risk of thrombotic even...
Daratumumab plus cyclophosphamide, bortezomib and dexamethasone in newly diagnosed patients with light-chain amyloidosis: Interim analysis from an Italian, multicenter, retro-prospective real-world experience
Abstract Systemic immunoglobulin light-chain (AL) amyloidosis is a rare plasma cell disorder caused by a clone producing unstable misfolded...
Evaluating gvhd outcomes after chemotherapy-only conditioning in nicotinamide-expanded umbilical cord blood (omidubicel) transplantation: A retrospective cohort study
Abstract INTRO: Omidubicel (Omi) is an ex vivo expanded hematopoietic progenitor cell product derived from a single umbilical cord blood (UC...
Dara-RVD in newly diagnosed multiple myeloma: Real-world clinical practice
Abstract Background: Despite significant advances in therapy, multiple myeloma (MM) remains an incurable disease thus far. Patients with hig...
Epcoritamab combinations demonstrate promising efficacy in patients (pts) with Richter transformation (RT): First results from arms 2B (epcor + lenalidomide [LEN]) and 2C (epcor + R-CHOP) of the phase 1b/2 EPCORE CLL-1 trial
Abstract Introduction: RT is an aggressive transformation of chronic lymphocytic leukemia (CLL), most often into diffuse large B-cell lympho...
Non-response to bridging therapy prior to CAR-T is associated with increased toxicity and adverse outcomes in Relapsed/Refractory multiple myeloma (RRMM)
Abstract Background: Bridging therapy (BT) is critical for delivering chimeric antigen receptor T (CAR-T) therapy in patients with RRMM as m...
Transferrin receptor 2 (Tfr2) is necessary for hepcidin induction in mice with hepatocyte-specific transferrin receptor 1 (Tfr1) deficiency
Abstract In hepatocytes, transferrin receptor 1 (Tfr1) does not have a major role in iron acquisition but rather controls signaling to the i...
LILRB4 drives proinflammatory cytokine secretion in multiple myeloma to promote the immune-cell dysfunction via the generation of myeloid-derived suppressive cells
Abstract Recent advancements in the treatment of multiple myeloma (MM), including immunomodulatory agents, monoclonal antibodies, and T cell...
Clinical characteristics, treatment patterns, clinical outcomes and resource utilization in patients with chronic lymphocytic leukaemia (CLL): CREEK-Latin America subgroup analysis
Abstract Introduction: There is an unmet need to understand how novel therapies translate into real-world clinical practice for CLL, particu...
Targeting mitochondrial metabolism to suppress neutrophil overactivation in sepsis: Therapeutic potential of the mitochondrial uncoupler BAM15
Abstract Background: Understanding the immunometabolic reprogramming that occurs during sepsis is crucial for designing future therapeutics...
Endothelial SRSF1 regulates hematopoietic stem cell function in the bone marrow microenvironment
Abstract The bone marrow (BM) microenvironment is a dynamic cellular network composed of endothelial cells (ECs) and EC-associated perivascu...
Rising sepsis-related mortality in aplastic anemia: A u.S. population-based analysis of temporal trends, disparities, and forecasts through 2030
Abstract Background: Patients with aplastic anemia (AA) are at increased risk of sepsis-related mortality due to underlying immunosuppressio...
Treatments and outcomes of adult patients with TP53-mutated acute myeloid leukemia (AML) in the real-life –Report of the prospective french observational ALFA-PPP study.
Abstract Introduction The prognosis of AML harboring TP53 mutations remains exceptionally poor. Clinical trials specifically designed for TP...
Association of race and ethnicity and incidence and severity of hyperglycemia and clinically-treated hypertension during induction therapy for pediatric acute lymphoblastic leukemia
Abstract Background: Anti-cancer therapies used to treat pediatric acute lymphoblastic leukemia (ALL) achieve high cure rates but can cause...
Outcomes of diffuse large B-cell lymphoma and high-grade B-cell lymphoma in elderly patients aged ≥ 80 years-old treated in first line therapy: An analysis of the bra-DLBCL multicenter, real-world registry, retrospective study
Abstract Introduction Only a few studies have been conducted in elderly patients with diffuse large B-cell lymphoma (DLB...
Scoping review of current practices and recommendations on fertility preservation in sickle cell disease
Abstract Introduction: Sickle cell disease and its treatments, mainly hydroxyurea and transformative therapies, are associated with male and...
Age-ing study: A prospective evaluation of geriatric, patient-reported and frailty assessments to predict outcomes in older adults with acute myeloid leukemia
Abstract Background: Acute myeloid leukemia (AML) primarily affects older adults. Despite the survival benefit of intens...
FLT3-ITD drives poor prognosis in NPM1 mutated AML via BCAT1-dependent epigenetic regulation
Abstract NPM1 mutations (NPM1mut) are detected in approximately 30% of adult AML cases. Patients with coexisting NPM1 mutations and FLT3-ITD...
Enhanced CD34+ cell mobilizations, collections, and comparable safety profile with fixed-dose versus weight-based plerixafor dosing in patients with sickle cell disease receiving autologous CD34+ base-edited hematopoietic stem cells (BEAM-101) in the ongoing BEACON study
Abstract Introduction Autologous transplantation with genetically modified hematopoietic stem and progenitor cells (HSPCs) for sickle cell d...
Unsupervised proteomic and metabolomic longitudinal serum profiling of anti-CD19 CAR-T cell therapy recipients reveals clinically distinct groups
Abstract Introduction: Despite the clinical success of Chimeric Antigen Receptor (CAR)-T cell therapy, it still faces multiple challenges, s...
Evaluating the impact of AI tools on diagnostics and management of hematologic malignancies (2020–2025): A systematic review
Abstract Background: In recent years there has been rapid growth in artificial intelligence (AI) applications for hematologic malignancies....
Rapid normalization of platelet counts in patients with refractory thrombocytopenia associated with systemic lupus erythematosus (SLE) following treatment with allogeneic dual-target CD19/BCMA CAR T-cell therapy (QT-019B)
Abstract Background Systemic lupus erythematosus with immune thrombocytopenia (SLE-ITP) is a severe condition associated with poor prognosis...
Thyroid hormones enhance the responsiveness of T-cell lymphomas to romidepsin
Abstract T-cell lymphomas (TCL) are aggressive and clinically heterogeneous malignancies originating from mature or immature T cells. Standa...
Computed tomography quantification of body adiposity and induction outcomes in patients with newly diagnosed acute lymphoblastic leukemia
Abstract Background Obesity is encountered in up to 40% of children and adolescents who initiate acute lymphoblastic leu...