Blood
Articles in this Issue
Stepwise genetic testing refines the diagnosis of suspected congenital dyserythropoietic anemias: A cohort study of 76 Indian families
Abstract Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of inherited red cell disorders characterized by ineffective...
A single-arm, open-label trial to evaluate the efficacy and safety of reduced-dose daratumumab in combination with bortezomib and dexamethasone (DVd-lite) in patients with newly diagnosed monoclonal gammopathy of renal significance (MGRS)
Abstract Background: Clone-directed therapy is essential for managing monoclonal gammopathy of renal significance (MGRS), as it reduces neph...
Humanized anti-CD25 monoclonal antibody for previously treated hemophagocytic lymphohistiocytosis in adults: A prospective, open-label clinical trial
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by immune dysregulation and hyperinflammation. It is asso...
Advancing adoption of evidence-based quadruplet treatment regimens for newly diagnosed multiple myeloma in community practice: Insights from a quality improvement initiative
Abstract Background Quadruplet regimens (anti-CD38 monoclonal antibody added to the proteasome inhibitor and immunomodulatory drug backbone)...
Real-world clinical characteristics and treatment outcomes in PNH patients prescribed pegcetacoplan across europe, the United States and Canada
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare blood disease characterized by uncontrolled complement activa...
Efficacy and safety of zanubrutinib in patients with non-IgM lymphoplasmacytic lymphoma
Abstract Introduction Zanubrutinib (ZANU), a second-generation BTK inhibitor, was approved in 2021 for the treatment of...
New evidence that complement activation and NLRP3 inflammasome signaling work together to cause cytokine release syndrome after CAR-T cell therapy
Abstract Background: Cytokine release syndrome (CRS) is a common and potentially serious complication of chimeric antigen receptor T-cell (C...
Lenalidomide-related diarrhea is associated with gut microbiota dysbiosis and disruption of the bile acid pool
Abstract Background Lenalidomide is a cornerstone of multiple myeloma (MM) treatment, but frequently causes gastrointestinal (GI) toxicity,...
Prognostic impact of MRD negativity in AML patients treated with venetoclax-based therapy: A systematic review and meta-analysis
Abstract TITLE: PROGNOSTIC IMPACT OF MRD NEGATIVITY IN AML PATIENTS TREATED WITH VENETOCLAX BASED THERAPY: A SYSTEMATIC REVIEW AND META ANAL...
Polygenic scores as a clinical diagnosis tool for abnormal hematological values
Abstract Background Abnormal hematological values are one of the most frequent reasons for hematological consultations....
Epidemiologic clues, current management and diagnostic trends in idiopathic budd-chiari syndrome: Implications of PNH and diagnostic testing
Abstract Budd-Chiari Syndrome (BCS), characterized by thrombosis of the hepatic vein, is a classical complication of PNH. While BCS can be a...
Myc super-enhancer dynamics in T-ALL
Abstract Mutations in non-coding regulatory elements are increasingly recognized as critical drivers of cancer development and progression....
Fixed-duration subcutaneous mosunetuzumab continues to demonstrate high rates of durable responses in patients with relapsed/refractory follicular lymphoma after ≥2 prior therapies: 3-year follow-up from a pivotal Phase II study
Abstract Background: In a pivotal Phase II study (NCT02500407), subcutaneous (SC) mosunetuzumab (Mosun), a CD20xCD3 T-cell engaging bispecif...
An interim assessment of bleeding events in a prospective natural history study of hereditary hemorrhagic telangiectasia patients using a validated bleeding scale and a novel daily reporting instrument
Abstract Background Hereditary hemorrhagic telangiectasia (HHT) is an inherited bleeding disorder characterized by recurrent hemorrhagic eve...
Assessing diagnostic accuracy of DermPathGPT01 for dermatologic diagnosis in post-allogeneic stem cell transplant patients
Abstract Introduction Cutaneous complications are common among patients undergoing allogeneic hematopoietic stem cell transplantation (allo-...
Exploratory analysis from HAVEN 1–4 to further contextualize injection-site reactions among people with hemophilia A receiving emicizumab
Abstract Background: Long-term data with subcutaneous emicizumab prophylaxis in people with hemophilia A (PwHA) with or without factor (F)VI...
Multicenter prospective Phase II study of decitabine priming combined with low-dose idarubicin, cytarabine, and G-CSF in children with refractory or relapsed Acute Myeloid Leukemia
Abstract Background: As of 2018, no standard salvage regimen had been established for pediatric relapsed or refractory acute myeloid leukemi...
Effect of the dominant-negative ikaros isoform 6 (Ik6) on cell function and drug sensitivity in acute lymphoblastic leukemia cell lines
Abstract Objective IKZF1 deletions occur commonly in patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poo...
Healthcare utilization in patients with sickle cell disease on buprenorphine for chronic pain
Abstract Introduction: Patients with sickle cell disease (SCD) often experience acute and chronic pain that necessitates...
Single-cell transcriptomic studies reveal altered heterogeneity in CD41 enriched megakaryocytes after targeted therapy in myeloproliferative neoplasm
Abstract Recent single cell studies have shown that the megakaryocyte (MK) lineage is heterogeneous with multiple sub-populations such as im...
Neutropenia, infections, and mortality across Acute Myeloid Leukemia induction strategies: A single center retrospective study
Abstract Introduction Infectious complications are a major cause of morbidity and mortality in acute myeloid leukemia (AML). While cytarabin...
Multiple time-point FDG-PET imaging for risk stratification of patients with relapsed/refractory large B-cell lymphoma undergoing CD19-directed CAR-T cell therapy
Abstract Introduction CD19-directed CAR-T cell therapy is a curative approach for patients (pts) with relapsed/refractory (r/r) large B-cell...
Temporal trends and disparities in non-Hodgkin lymphoma related mortality along the US-Mexico border from 1999 to 2020: CDC wonder analysis
Abstract Background: Non-Hodgkin Lymphoma (NHL) is a hematological cancer that affects the lymphatic system, and is characterized by the abn...
Baseline CD4 count is associated with early mortality in HIV-associated lymphoma: A retrospective cohort study
Abstract Background: HIV-associated lymphomas remain a leading cause of cancer-related mortality among people living wit...
IFN-γ driven hepatic injury exacerbates mortality in NK/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis
Abstract Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (N...