Blood
Articles in this Issue
Blood and filters: The intersection of myelodysplastic syndrome and renal failure in u.S. mortality trends (1999–2023)
Abstract Introduction: Myelodysplastic syndromes (MDS) are clonal bone marrow disorders with a major worldwide and U.S....
Novel composite end-points toxicity/progression-free survival (tfPFS) and toxicity-free complete remission (tfCR100) after CAR-T cell therapy for diffuse large B cell lymphoma: Cell therapy consortium analysis.
Abstract The success of CAR T is typically assessed by disease response and rates of immune complications like Cytokine Release Syndrome (CR...
Allogeneic induced pluripotent stem cell-derived invariant natural killer T cell therapy: A phase 1 clinical Trial
Abstract Introduction: The invariant Natural Killer T (iNKT) cell is a T cell subset characterized by the expression of...
Results of abatacept addition to post transplant cyclophosphamide-based GVHD prophylaxys in allogeneic hematopoyetic stem cell transplantation
Abstract Background: Graft-versus-host disease (GVHD) remains a leading cause of morbidity and mortality following allogeneic hematopoietic...
Cardiovascular disease risk scores as predictors of cardiovascular disease and heart failure in allogeneic hematopoietic cell transplant survivors
Abstract Survivors of allogeneic hematopoietic cell transplant (allo-HCT) have a significantly higher risk of developing atherosclerotic car...
Implementation challenges of the learner clinical trial in pregnant women with sickle cell disease in Angola
Abstract Sickle Cell Disease (SCD), a severe inherited blood disorder, poses significant risks during pregnancy, particularly in regions lik...
Romiplostim N01 enhances platelet engraftment in ASCT using non-cryopreserved pbscs for plasma cell neoplasms: A single-center phase II study in China
Abstract Autologous hematopoietic stem cell transplantation (ASCT) remains a standard of care for plasma cell neoplasms, including multiple...
Dynamic mutational evolution and transcriptomic remodeling on 3rd-generation TKI therapy in TKI-resistant patients with chronic myeloid leukemia
Abstract BackgroundThird-generation tyrosine kinase inhibitors (3G-TKIs), olverembatinib and ponatinib, improved outcomes for patients with...
SETD2 deficiency in chronic myeloid leukemia (CML) contributes to tyrosine kinase inhibitor (TKI) resistance and disease acceleration by enhancing genetic instability and rewiring cellular metabolism and might be a novel biomarker of high risk disease since diagnosis
Abstract There is an active quest for biomarkers of high-risk disease in CML. ASXL1 and other cancer gene mutations, some additional cytogen...
Comparative long-term cardiovascular and hematologic outcomes of gemtuzumab ozogamicin containing regimens versus idarubicin containing regimens in acute promyelocytic leukemia: A propensity-matched analysis of real-world multicenter data
Abstract Background All-trans retinoic acid (ATRA)-based regimens have revolutionized the treatment of acute promyelocyt...
Preliminary pharmacokinetic and MRD results from AML patients treated with 7- and 14-day dosing schedule of emavusertib added to combination therapy with azacitidine and venetoclax
Abstract Background Emavusertib, an oral IRAK4 and FLT3 inhibitor, is being tested in a Phase 1, single-arm, open-label,...
Platelet dysfunction in Ehlers–Danlos syndrome is associated with low GPVI and PAR1 expression on platelets
Abstract Introduction: People with Ehlers–Danlos syndrome (EDS) are at an increased risk for hemorrhagic events, which can range from minor...
All-trans retinoic acid mitigates IL-1β-driven NEU1-mediated megakaryocyte desialylation and dysfunction in immune thrombocytopenia
Abstract Introduction Immune thrombocytopenia (ITP) is marked by autoimmune platelet destruction and impaired thrombopoiesis, with neuramini...
Mendelian randomization reveals the causative role of genetically predicted viral infection in pan-lymphoma risk
Abstract Background: While observational studies have suggested associations between viral infections and lymphoma risk, causal relationship...
Refined design of a CD117 antibody-drug conjugate safely and effectively conditions non-human primates for autologous transplant-based gene therapy
Abstract Introduction: Standard chemotherapy and irradiation-based conditioning for hematopoietic stem cell transplant (HCT) and autologous-...
Prospective hydroxyurea impact on cerebral magnetic resonance imaging from a 30-month trial of children with sickle cell anemia in Uganda
Abstract Introduction: Children with sickle cell anemia (SCA) often develop cerebral vasculopathy early in life. Vascular injury is manifest...
Analysis of safety and efficacy of carmen, GMALL, LMB, and other intensive chemotherapy combinations in an international series of HIV-positive patients with burkitt lymphoma: A study of the HIV lymphoma network of the european hematology association
Abstract Introduction: Current treatment strategy for HIV-associated Burkitt lymphoma (BL) typically rely on intensive chemotherapy regimens...
Treatment-requiring paroxysmal nocturnal hemoglobinuria in association with myeloproliferative neoplasms (MPNs): Clinical correlations and outcomes
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by PIGA mutations, resulti...
Validation of the FL/IL6 score, a new dynamic cytokine-based risk-model in adults with acute myeloid leukemia, a prospective multicentre filo study.
Abstract Background: In a recent monocentric study in adults with acute myeloid leukemia (AML), it was shown that combining the kinetic prof...
Autologous CD19-directed CAR-T exhibit promising safety and efficacy in refractory primary immune thrombocytopenia
Abstract Background: Refractory primary immune thrombocytopenia (ITP) patients are characterized by great treatment diff...
Glofitamab plus gemcitabine and oxaliplatin (GemOx) vs rituximab (R)-GemOx in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): Efficacy and safety in patient subgroups
Abstract Background Glofitamab, a CD20xCD3 bispecific antibody, plus GemOx (Glofit-GemOx) has shown overall survival (OS), progression-free s...
Differential prognostic impact of chromatin modifier mutations in peripheral T-cell lymphoma: KMT2A emerges as a critical biomarker
Abstract Background: Peripheral T-cell lymphomas (PTCLs) remain one of the most challenging lymphoma subtypes to treat, with consistently po...
LOX1 expression identifies a population of polymorphonuclear myeloid-derived suppressor cells that are highly enriched in bone marrow samples of treatment-Naïve and BTKi-Relapsed/Refractory WM patients and show constitutive activation of BTK
Abstract Introduction: Immune microenvironment dysregulation is a hallmark of early/smoldering Waldenstrom's Macroglobulinemia (WM) that und...
Unfavorable outcomes in pediatric PAX5r B-cell precursor acute lymphoblastic leukemia: FLT3 targeting as a potential novel treatment strategy
Abstract Background: PAX5-altered acute lymphoblastic leukemia (PAX5alt ALL) is a recently defined molecular subtype of BCP-ALL, which displ...
Targeting ephrin A3 in the bone marrow niche offers a promising therapeutic strategy to impede hematopoietic stem cell maintenance in MDS patients
Abstract Myelodysplastic syndrome (MDS) comprises a group of clonal stem cell disorders characterized by ineffective haematopoiesis. Using h...