Blood
Articles in this Issue
Mutational architecture and clonal heterogeneity in myelofibrosis: Prognostic role of variant type and acquisition sequence
Abstract BACKGROUND: The spectrum of somatic mutations of myeloid-associated genes in patients (pts) with myelofibrosis (MF) has been extensi...
IgD-related AL amyloidosis: Clinical features and outcomes
Abstract Background: Immunoglobulin D (IgD)-related AL amyloidosis is a rare subtype, representing approximately 1% of AL amyloidosis cases,...
Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia
Abstract Although patients with acute myeloid leukemia (AML) initially respond to standard chemotherapy, the relapse rate is high, and many...
Cell differentiation stage drives mechanisms of apoptosis evasion in Waldenström macroglobulinemia
Abstract Waldenström Macroglobulinemia (WM) is an incurable lymphoid malignancy characterized by a spectrum of differentiation states from c...
Changes in complete blood count (CBC) and white blood cell (WBC) differential associated with overweight and obesity: A patient-level meta-analysis of randomized trials
Abstract Introduction: Obesity is a global public health concern associated with multiple comorbidities and adverse health outcomes. Hematol...
Combination of mitoxantrone hydrochloride liposome with chidamide in patients with relapsed or refractory peripheral T cell lymphoma: Updated results of the phase II study
Abstract Background Relapsed or refractory (R/R) peripheral T cell lymphoma (PTCL) is an aggressive and heterogeneous malignancy without stan...
Endothelial dysfunction and proinflammatory state determine severe hematotoxicity and adverse outcome of CAR-T therapy
Abstract Hematotoxicity with prolonged cytopenia is the most relevant high-grade toxicity after chimeric antigen receptor (CAR)-T therapy. I...
Brentuximab vedotin (Bv)+AVD efficacy is influenced by interim PET, age, ECOG performance status and CIRS-g in previously untreated patients with stage IV classical Hodgkin lymphoma: An Italian real-life multicentric study
Abstract Introduction: In Italy, Brentuximab vedotin (Bv) with AVD (adriamycin, vinblastine, dacarbazine) received approval for the first-li...
Retrospective cohort analysis of treatment patterns and bleeding outcomes in the Korean bleeding disorder registry (KBDR)
Abstract Background Hemophilia is a rare congenital bleeding disorder characterized by the deficiency of clotting factor...
The impact of voxelotor on the reduction in red blood cell transfusions in US patients with sickle cell disease
Abstract Background: The current treatment landscape for SCD is limited, and treatment options have associated risks and can be burdensome f...
Thrombocytosis in transient abnormal myelopoiesis: Association with megakaryocytic skewing and GATA1 mutation patterns
Abstract Background & Objectives: Transient abnormal myelopoiesis (TAM) is a unique neonatal hematological disorder associated with Down...
Thromboembolism and event-free survival in children with extracranial solid tumors: A report from CYP-c.
Abstract Background: Thromboembolism (TE) is a known complication in pediatric oncology patients. While its adverse prognostic impact on sur...
SMARCC1 loss impairs differentiation and enhances self-renewal in ASXL1-mutant hematopoietic cells
Abstract Additional sex combs-like 1 (ASXL1) is a histone modifier regulating hematopoiesis. Its mutations are common in secondary acute mye...
CD20 (MS4A1) mutations are strongly associated with prior chemoimmunotherapy exposure in Waldenström macroglobulinemia and have predicted functional consequences for the development of CD20-directed cellular therapies.
Abstract Introduction: CD20, encoded by MS4A1, is one of the earliest and most extensively used therapeutic targets in B-cell malignancies. I...
Targeting the methylome in T-LGL leukemia: Pre-clinical analysis and Results of a Phase I trial with oral 5-azacytidine
Abstract Epigenetic dysregulation, particularly changes in DNA methylation, are major contributors to the onset and progression of Large Gra...
Impact of central nervous system prophylaxis on survival outcomes in patients with primary testicular diffuse large B-cell lymphoma: A single-center analysis
Abstract Introduction Primary testicular diffuse large B-cell lymphoma (PTL) is characterized by a high risk of relapse...
Prognostic implications of measurable residual disease and autologous hematopoietic stem cell transplantation in primary plasma cell leukemia in the era of novel agents
Abstract Background:Primary plasma cell leukemia (pPCL) is the most aggressive malignancy of plasma cell neoplasms, with a median overall su...
Prognostic significance of IKZF1 deletion subtypes in ph-negative BCP-ALL: Biallelic-null deletion predicts the worst survival in TP53-wild type patients
Abstract Background: Recent advances in molecular cytogenetic profiling of B-cell precursor acute lymphoblastic leukemia...
Healthcare resource utilization in patients receiving quizartinib or placebo in combination with chemotherapy for newly diagnosed, FLT3-ITD+ acute myeloid leukemia: An analysis from the QuANTUM-first trial
Abstract Introduction: The global, randomized, placebo (Pbo)-controlled, phase 3 QuANTUM-First trial (NCT02668653) evaluated quizartinib (Qu...
Nanobody-based CD19/CD20 bispecific CAR-T achieves durable remissions in r/r NHL patients
Abstract Background: While CD19-targeting chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in relapsed/ref...
Clinical characteristics and whole-exome sequencing-based genomic profiling of post-transplant lymphoproliferative disorders following allogeneic hematopoietic stem cell transplantation
Abstract Background: Post-transplant lymphoproliferative disorder (PTLD) is a lymphoid neoplasm that arises in the context of immunosuppress...
Integrated analysis of autoantibody profiles and clonal distribution of RAS mutations in juvenile myelomonocytic leukemia
Abstract Background: Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive myelodysplastic/myeloproliferative neoplasm occurring i...
Social vulnerability predicts higher county-level pulmonary embolism mortality in the United States : A 2016-2020 nationwide analysis
Abstract Introduction: Pulmonary Embolism (PE) remains a leading cause of mortality in adults in U.S. contributing to an estimated 100,000 c...
Antigen-dependent clonal sweep with sequential or combinatory anti-myeloma T cell engagers
Abstract Bispecific T cell engagers (TCE) have led to significant therapeutic advances in multiple myeloma (MM), however with finite durabil...
Phase I/II study of decitabine/cedazuridine (ASXT727), venetoclax, and gilteritinib for patients with FLT3-mutated Acute Myeloid Leukemia or high-risk myelodysplastic syndrome
Abstract Background: Patients (pts) with FLT3-mutated acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy (IC) or wit...