Blood
Articles in this Issue
Inflammatory remodeling and CD4+ T cell expansion in TET2-mutated myeloid disorders
Abstract Ten-eleven translocation 2 (TET2) encodes a DNA demethylation enzyme, and it is one of the most frequently mutated genes in myeloid...
Disparities in sickle cell disease related mortality in the US-Mexico border region from 1999 to 2020: A CDC wonder Study
Abstract Background: Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a point mutation in the β-globin gene, resulting i...
A quality improvement project to optimize IVC filter use and retrieval: Translating guidelines into practice
Abstract Introduction Inferior vena cava (IVC) filters are used to prevent pulmonary embolism (PE) in patients with venous thromboembolism (...
Novel method of minimal residual disease testing in myeloma: Liquid biopsies to enumerate and 3D telomere-profiling of circulating tumor cells
Abstract Introduction: Novel therapeutic approaches, especially cellular therapies, have significantly prolonged the survival of patients wi...
Upregulation of extracellular matrix remodeling gene set drives progression and poor prognosis in angioimmunoblastic T-cell lymphoma.
Abstract Introduction Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive and heterogeneous peripheral T-cell lymphoma derived from f...
A multicenter, randomized, open-label study of dexamethasone versus romiplostim plus dexamethasone as first line treatment in patients with newly diagnosed immune thrombocytopenia: Interim results of rodex study
Abstract Background: Corticosteroids remain the standard first-line treatment for immune thrombocytopenia (ITP), yet less than 40% of patien...
Targeting hemolysis and raas: Osivelotor and losartan ameliorate sickle cell renal pathology
Abstract In sickle cell disease (SCD), progressive renal dysfunction is common and driven by mechanisms such as chronic hemolysis, vascular...
Serum albumin, but not gnri, is an independent prognostic factor for survival after first allogeneic SCT: A large-scale multicenter analysis
Abstract Background: While we previously reported that the geriatric nutritional risk index (GNRI) is a strong independent prognostic factor...
Protac-mediated degradation of neutrophil elastase as a potential therapeutic strategy for ELANE-related neutropenia
Abstract Background: Mutations in ELANE are the most common cause of both cyclic and severe congenital neutropenia. ELAN...
A novel Janus kinase 1 and 2 inhibitor, baricitinib, for steroid-refractory chronic graft-versus-host disease after allogeneic stem cell transplantation
Abstract Introduction Allogeneic stem cell transplantation (allo-SCT) is an effective and straightforward therapy for hematology patients, a...
The impact of environmental air exposues on disease characteristics and outcomes in a cohort of patients with myelofibrosis
Abstract Introduction: Disparate outcomes have been reported in patients (pts) with myeloproliferative neoplasms (MPNs), such as increased r...
Socioeconomic inequality in acute myeloid leukaemia treatment in England: What drives this inequality
Abstract Introduction: Socioeconomic inequalities in survival of acute myeloid leukaemia (AML) exist. In a private healthcare context such a...
Results of POLARIS-1, a global Phase 3 study (Part A): Olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL)
Abstract Introduction Ph+ ALL is the most common genetic subtype of adult ALL, is associated with high relapse risk and poor outcomes, and i...
Activation of endogenous retroviral elements drives inflammation and transformation in STAG2-mutant myeloid malignancies
Abstract Cohesin is a multimeric protein complex that regulates three-dimensional chromatin architecture and gene regulation. In myeloid mal...
Circulating extracellular Vesicle–Derived mirnas identify a high-risk subgroup in extranodal NK/T-cell lymphoma with caebv-like features
Abstract Background Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a distinct lymphoma subtype associated with Epstein-Barr virus...
Characteristics and clinical outcomes of patients (pts) with Acute Myeloid Leukemia (AML) with Mecom rearrangements: An analysis from the MARROW consortium
Abstract Background: MECOM-rearranged (MECOM-r) AML is a rare AML subtype that is characterized by the disease-defining inv(3)(q21q26.2), t(...
Pola-R-CHP in newly diagnosed primary mediastinal B-cell lymphoma:high efficacy and tolerability
Abstract Introduction Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL) that predominant...
Clinical profiling and outcomes of ischemic stroke patients with immune thrombocytopenia: A multicenter real-world study
Abstract Introduction Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by platelet destruction mediated by aut...
Prognostic variables associated with the development of cytokine release syndrome after bispecific antibodies in non-Hodgkin lymphoma patients – the geltamo (Spanish Lymphoma Group) experience
Abstract Introduction Cytokine release syndrome (CRS) is a common toxicity observed during the step-up dosing of bispecific antibody (BsAb) t...
Anthropometric data from a large cohort of Indian sickle cell disease subjects.
Abstract Introduction Sickle cell disease (SCD) is the most common monogenic disorder in India and globally, contributing to non-communicabl...
Vag regimen drives immune reprogramming and superior remission in older/unfit AML patients
Abstract Targeted therapies have transformed the treatment landscape of hematological malignancies; however, meaningful progress for older/u...
Platelet mitofusin-1 mediates endothelial cell dysfunction in pulmonary arterial hypertension via the NLRP3 inflammasome and interleukin-1B
Abstract Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder driven by metabolic and endothelial cell dysfunction (E...
Trial in progress: A pilot study of venetoclax to AUGMENT epigenetic modification and chemotherapy in pediatric and young adult patients with relapsed and refractory Acute Myeloid Leukemia
Abstract Background and Significance: Effective treatment for children with relapsed/refractory (R/R) acute myeloid leukemia (AML) remains a...
Safety and efficacy of out-of-specification ciltacabtagene autoleucel (cilta-cel) in Relapsed/Refractory multiple myeloma (RRMM)
Abstract Background: Cilta-cel is an anti-B-Cell maturation antigen (BCMA) CAR T-cell therapy approved for RRMM. Manufacturing failure (MF)...
Increased incidence of delayed methotrexate elimination in pediatric patients with Philadelphia-chromosome positive (Ph+) or ABL-class fusion positive (ABL-Class) acute lymphoblastic leukemia treated with imatinib: Results of a retrospective cohort study by the italian association of pediatric hematology-oncology (AIEOP)
Abstract Background: High-dose methotrexate (HDMTX) is a key component of the treatment of pediatric acute lymphoblastic leukemia (ALL). Tho...