Blood
Articles in this Issue
Adverse genetic alterations and their prognostic impact in Chinese b-ALL patients with DUX4 rearrangement
Abstract Background: B-cell acute lymphoblastic leukemia (B-ALL) is a heterogeneous group of hematological malignancy with many molecular sub...
Mim8 improves the In Vivo hemostasis of select hemophilia B causing factor IX variants
Abstract Introduction Emicizumab, a first-generation factor VIIIa (FVIIIa)-mimetic, has revolutionized prophylaxis for people with hemophili...
Cdk6 targeting reverses leukemia in germline cebpa Q83X AML mouse model with CMP-origin transformation
Abstract CEBPA mutations are frequent drivers of familial AML (FAML) and common in sporadic disease. While bZIP-in-frame mutations (bZIP-if)...
WM-voice: An international discrete choice experiment on treatment preferences in 1,455 patients with Waldenström macroglobulinemia
Abstract Introduction: Waldenström macroglobulinemia (WM) is a rare and incurable low-grade non-Hodgkin lymphoma. Therapeutic options are ra...
Real-world outcomes of platelet transfusion in heparin-induced thrombocytopenia: A five-year national study
Abstract Background: Heparin-induced thrombocytopenia (HIT) is a prothrombotic, immune-mediated complication of heparin exposure, typically...
Epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Hawaii
Abstract Introduction: The epidemiology and clinical characteristics of familial myelodysplastic syndromes/acute myeloid leukemia (MDS/AML)...
Phase 2 trial of cladribine plus immediate rituximab for 1st-line treatment of hairy cell leukemia – long term follow-up of original and additional patient cohorts
Abstract Background: Hairy cell leukemia is a B-cell malignancy presenting with cytopenias and splenomegaly. It responds well to purine analo...
Long-term safety and effectiveness of systemic bevacizumab for chronic severe bleeding in idiopathic gastrointestinal angiodysplasia, esophageal varices, and angiodysplasia of von willebrand disease and acquired von willebrand syndrome
Abstract Background Angiodysplasia of the gastrointestinal (GI) tract may be idiopathic or occur secondary to other causes, such as von Will...
Line-of-therapy stratified efficacy of belumosudil in cgvhd : Real-world evidence
Abstract Background: In China, belumosudil has been approved for patients failing ≥1 prior therapy, yet dedicated evidence supporting its se...
Race/ethnicity reporting and representation in clinical trials presented at plenary and late-breaking abstract sessions at the American society of hematology (ASH) from 2014 to 2024
Abstract Diversity of clinical trial participants helps ensure generalizability of results to real world patient populations. Despite signif...
Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis
Abstract Background: Sickle cell crisis (SCC) remains a leading cause of emergency hospitalization and acute morbidity i...
Aromatherapy oil during bone marrow biopsy procedure and association with anxiety and pain: An interim analysis
Abstract Background: Bone marrow aspiration and biopsy (BMAB) is an important procedure for those diagnosed with hematol...
Aberrant thymic architecture and enhanced interferon signaling in down syndrome
Abstract Disrupting the mechanisms of thymocyte development and central tolerance can severely affect the immune system and lead to autoimmu...
Management of a real-world cohort of patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan: A multi-institutional analysis
Abstract Introduction: Iptacopan, the first oral complement inhibitor, offers an attractive alternative to parenteral complement blockers in...
Unveiling FLT3 in B-ALL: Molecular drivers and targeted treatment opportunities
Abstract Backgroud : The prognosis of B-cell Acute Lymphoblastic Leukemia (B-ALL) patients relapsing after Hematopoietic Stem Cell Transplan...
SLF2 and SMC5 are novel causative genes for inherited bone marrow failure syndromes, driving HSC aging and predisposing to MDS
Abstract Although many causative genes have been identified in inherited bone marrow failure syndromes (IBMFS), the genetic etiology remains...
Menin-inhibition boosts CAR-T cell therapy against NPM1 mutated and KMT2A-rearranged acute myeloid leukemia
Abstract Inhibitors disrupting the Menin-KMT2A chromatin complex have emerged as an auspicious treatment for KMT2A-rearranged (KMT2A-r) leuk...
Results of the Phase 1B study of pegargiminase (ADI-PEG 20) in combination with AZA-VEN in newly diagnosed high-risk AML patients not candidates for intensive chemotherapy
Abstract Background Tumor metabolism is a promising area for drug development in AML. Pegargiminase (ADI-PEG 20), a meta...
Acquired hemophilia a results from a provincial registry highlight the need for improvement of clinical outcomes and bypassing agent use
Abstract Background Acquired Hemophilia A (AHA) is a rare disease with substantial morbidity and mortality. High quality evidence to guide a...
Measurable residual disease in newly diagnosed multiple myeloma: Experience from a large cohort from an academic medical center
Abstract Introduction Achieving undetectable measurable residual disease (MRD) is associated with improved progression-f...
Proteomic landscape of histiocytic neoplasms: Advancing precision biomarkers, molecular mechanism, and targeted therapies
Abstract Introduction Histiocytic neoplasms are rare hematological disorders characterized by clonal proliferation of myeloid-derived cells....
Survival differences in metropolitan versus nonmetropolitan/rural counties in the US: An analysis according to rural-urban continuum codes (RUCC) in the lymphoma epidemiology of outcomes (LEO) study cohort
Abstract Background: Rural/nonmetropolitan (nonmetro) counties face known barriers to comprehensive cancer care compared with metropolitan (...
Risk-adjusted comparison of survival in chronic myelomonocytic leukemia with and without allogeneic stem cell transplant: Mayo Clinic experience in 775 consecutive patients
Abstract Background: The recently published BLAST clinical risk model for chronic myelomonocytic leukemia (CMML) and its molecular version (...
Impact of cancer and therapy on the epigenetic landscapes of normal cells: Describing a novel biomarker in survivorship
Abstract Introduction: With the advent of modern multi-drug chemotherapy regimens, several aggressive hematologic malignancies now have exce...
CD19/CD22 bispecific CAR-t cell therapy for relapsed/refractory large b-cell lymphoma: A prospective, single-arm, single-center, phase 2 clinical trial
Abstract Background: Chimeric antigen receptor T-cells (CAR-T) targeting CD19 have shown promising benefits to patients of relapsed or refra...