Blood
Articles in this Issue
Artificial intelligence for diagnostic applications in rare hematologic malignancies: A systematic review
Abstract Rare hematologic malignancies (collectively accounting for ~20% of cancers) pose diagnostic challenges due to heterogeneous present...
Transcriptomic identification of functionally potent human hematopoietic stem and progenitor cells
Abstract Background: Allogeneic hematopoietic cell transplantation is a potentially curative treatment for malignant and non-malignant hemato...
Assessment of minimal residual disease with droplet digital polymerase chain reaction for BRAF V600E mutation in patients with hairy cell leukemia treated with purine analogs
Abstract Background. BRAF (V600E) mutation is the molecular hallmark of hairy cell leukemia (HCL), being detected in more than 95% of patien...
Activation effects of chidamide on BET signaling pathways and the mechanism of synergistic effect with BET inhibitors in Mantle Cell Lymphoma
Abstract Mantle cell lymphoma (MCL) is a rare, aggressive, and heterogeneous subtype of B-cell non-Hodgkin lymphoma. Emerging evidence sugge...
Targeting CCL3+mono like LSC overcomes chemotherapy resistance in NPM1 mutant AML
Abstract Background: Nucleophosmin 1 mutation (NPM1mut) represents one of the most frequent genetic alterations in acute myeloid leukmia (AML...
PNH-driven hepatic vein thrombosis: A case of budd-chiari syndrome in disguise“
Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder characterised by complement-mediated in...
NOTCH pathway activation is mediated by DTX1 loss of function mutations in DLBCL
Abstract Diffuse Large B Cell Lymphoma (DLBCL), the most common subtype of aggressive B-cell Non-Hodgkin Lymphoma (NHL), accounts for 30-40%...
Sequence-based artificial intelligence-guided inhibitory peptides to counteract AAV neutralizing antibodies in gene therapy
Abstract Background Gene therapy using adeno-associated virus (AAV) as a vector has been successfully applied in treatin...
Venetoclax-obinutuzumab in frontline and R/R CLL: Outcomes compared to age- and sex-matched general population
Abstract Background: The synergistic mechanisms of BCL-2 inhibitors and CD20-directed antibodies in the treatment of chronic lymphocytic leuk...
Subgroup analysis in pediatric patients from the Phase 3 study of tabelecleucel for allogeneic or solid organ transplant recipients with Epstein–Barr virus-driven post-transplant lymphoproliferative disease after failure of rituximab or rituximab and chemotherapy (ALLELE)
Abstract Background: Epstein–Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) is an ultra-rare complication wit...
Tallforest: Multi-omic classifier for T-lineage acute lymphoblastic leukemia
Abstract We previously demonstrated that T-lineage acute lymphoblastic leukemia (T-ALL) can be classified into 15 molecular subtypes based o...
Mutation-guided finite-duration acalabrutinib plus venetoclax for relapse after first-line finite-duration COVALENT Bruton tyrosine kinase inhibitor plus venetoclax‒based combination therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma: Phase 2 MAVRiC study
Abstract Background and Significance: For patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), fixed-duration t...
Macrophages mediate hematopoietic stem cell trans-endocytosis to coordinate regenerative stress and aging
Abstract The hematopoietic stem cell (HSC) niche is a specialized microenvironment in the bone marrow (BM) that controls HSC activity to ens...
Longitudinal assessments of minimal residual disease in high-risk patients from benefit phase 3 randomized Study of isatuximab plus lenalidomide and dexamethasone with bortezomib (Isa-VRd) versus isard in newly diagnosed transplant ineligible multiple myeloma. (IFM 2020-05)
Abstract Introduction. A recent international genomic consensus staging has standardized the high-risk (HR) definition on the basis of an NG...
Ibrutinib plus R-CHOP followed by maintenance in untreated ABC-DLBCL patients with IPI ≥2: A first analysis of phase II Study FIL_RI-CHOP
Abstract Background: Patients with activated (ABC) subtype diffuse large B-cell lymphoma (DLBCL) exhibit inferior outcomes following R-CHOP...
Murine modeling of cluster 1 diffuse large B-cell lymphoma reveals transformation from marginal zone lymphoma
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is a clinically and molecularly heterogeneous disease. Our comprehensive genomi...
The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut
Abstract Acute graft-versus-host disease (aGvHD) remains a serious complication of allogeneic stem cell transplantation (alloSCT), most comm...
Early administration of CD20 x CD3 bispecific antibodies 4-6 weeks after CAR-T infusion for patients with residual or progressive large B cell lymphomas
Abstract Background: CD19-directed CAR T-cell therapy (CAR-T) has improved outcomes and altered the treatment landscape for patients with re...
Clonal architecture inferred from routine NGS data predicts outcome and response to JAK-inhibitors in myelofibrosis
Abstract Background: Intra-tumor heterogeneity (ITH) and mutated variant allele frequency (VAF) were associated with poor outcomes in cancers...
Early flow cytometry-based MRD predicts relapse in intermediate-risk AML from low- and middle-income countries
Abstract Measurable Residual Disease (MRD) monitoring by Multiparametric Flow Cytometry (MPFC) is a powerful prognostic tool in Acute Myeloi...
Palliative care for AML patients on venetoclax-based therapy: A single-center real-world study
Abstract Background: Randomized trials demonstrate that patients with AML hospitalized for intensive chemotherapy benefit significantly from...
Navigating the complement cascade: A multicenter journey from pegcetacoplan to iptacopan in paroxysmal nocturnal hemoglobinuria
Abstract Introduction: The therapeutic landscape for paroxysmal nocturnal hemoglobinuria (PNH) has rapidly evolved with multiple proximal co...
Longitudinal genomic shifts associated with disease transformation in patients with polycythemia vera (PV) enrolled in REVEAL
Abstract Background: Molecular markers associated with PV progression to myelofibrosis (MF) or acute myeloid leukemia (AML) remain limited. T...
Teclistamab induced rapid and deep hematologic response in relapsed/refractory light chain amyloidosis: A multicenter retrospective study
Abstract Objective: Daratumumab-based therapy has significantly improved the prognosis of patients with light chain (AL) amyloidosis. Howeve...
Cytotoxic, natural killer-like ex-tissue resident memory T-cells circulate in human chronic graft-versus-host disease at diagnosis
Abstract Emerging evidence implicates tissue resident memory T-cells (TRM) in chronic graft-versus host disease (cGVHD) immunopathology. Whi...