Blood
Articles in this Issue
Reduced versus standard dose apixaban for secondary prevention of cancer-associated venous thromboembolism: A systematic review and meta-analysis
Abstract INTRODUCTION Cancer-associated venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a...
Radiomics-based identification of high-risk disease in newly diagnosed multiple myeloma
Abstract Introduction: Suboptimal response to therapy, early disease relapse, and limited long-term survival remain critical challenges in a...
Multi-omic single cell sequencing reveals discordant MRD and mechanisms of relapse in pediatric AML
Abstract Introduction: Pediatric acute myeloid leukemia (AML) is a biologically heterogeneous disease. Prognosis is determined by risk of re...
Grip strength predicts overall survival of patients with myelodysplastic syndrome in a multivariable model
Abstract Background: Myelodysplastic syndrome (MDS) is a clonal hematologic disorder characterized by cytopenias and a risk of progression t...
A diagnostic hematology clinic pilot program: Increasing access and optimizing resources
Abstract Introduction: The demand for specialized care in hematology is high and continues to rise. The complete blood count (CBC) is a wide...
Safety and effectiveness of brentuximab vedotin in Chinese patients with CD30-positive lymphomas: A multicenter real-world analysis
Abstract Introduction: Brentuximab vedotin (BV), an anti-CD30 antibody-drug conjugate, is approved for CD30-positive lymphomas. However, the...
Real-world response and toxicity profiles of sequential bispecific antibody therapies in Relapsed/Refractory multiple myeloma
Abstract Background Bispecific antibodies (BsAbs) targeting B-cell maturation antigen (BCMA) and G-protein receptor class C, group 5, member...
VGA039 as a protein S-targeted hemostatic promoting monoclonal antibody, promotes in-vitro thrombin generation in plasma samples from subjects across a broad range of bleeding disorders, including von Willebrand disease, hemophilia A, hemophilia B and hemophilia C
Abstract Introduction: VGA039 is a fully human IgG4 monoclonal antibody that targets protein S (PS), a negative regulator of coagulation. VG...
Developing β-thalassemia mouse model by deleting hbb genes for therapeutic evaluation
Abstract Introduction: Thalassemia is a group of inherited hemolytic anemias caused by defective hemoglobin synthesis, leading to shortened...
In-hospital outcome of first-time acute chest syndrome in patients with preexisting pulmonary hypertension: A nationwide analysis 2016-2022
Abstract Background: Although acute chest syndrome (ACS) and pulmonary hypertension (PH) are each recognized as risk fac...
Safety and efficacy of less differentiated CAR T-cell products in relapsed/refractory B-cell non-Hodgkin lymphomas: A meta-analysis
Abstract Introduction: CAR T-cell therapy has revolutionized the treatment of B-cell malignancies, particularly in heavily pretreated patien...
Efficacy and safety of orelabrutinib, obinutuzumab, and lenalidomide in previously untreated marginal zone lymphoma: Preliminary results from a prospective, single-arm, multicenter, Phase II study
Abstract Background: Emerging evidence suggests that triple-combination regimens incorporating Bruton tyrosine kinase (BTK) inhibitors, CD20...
Enhanced long-term outcomes with third-party unrelated cord blood co-infusion in a 122-patients cohort undergoing second allo-HSCT for AML in remission
Abstract Background While allo-HSCT is a curative approach for patients with hematologic malignancies, among them with relapse, graft failur...
Indirect treatment comparison (ITC) of asciminib and dasatinib in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP)
Abstract Introduction: First- and second-generation (1G and 2G) tyrosine kinase inhibitors (TKIs) have dramatically improved the outcomes of...
Positive outcomes associated with stem cell transplantation in pediatric/AYA patients who receive FLAG-IDA-venetoclax for high-risk AML
Abstract Background: BCL-2 inhibitors like venetoclax have demonstrated encouraging remission rates when combined with fludarabine, cytarabi...
CD4CAR T cells engage endogenous TCR to mediate antigen-independent cytotoxicity and distinct immune signatures.
Abstract Background: Chimeric antigen receptor (CAR) T cell therapy enables targeted tumor cell killing through synthetic receptors that rec...
Prognostic impact of co-occurring FLT3 mutations across molecular subgroups in intensively treated acute myeloid leukemia: Insights from real-world genomic data
Abstract Introduction FLT3 mutations (FLT3MUT) are among the most frequently altered genes in acute myeloid leukemia (AML), and exhibit subs...
Front‑line ponatinib vs imatinib in newly diagnosed Philadelphia‑positive ALL: Systematic review and meta‑analysis of survival and deep molecular response
Abstract Front-Line Ponatinib Versus Imatinib in Newly Diagnosed Philadelphia-Positive ALL: A Systematic Review and Meta-Analysis...
Lutetium-177 dotatate PRRT in GEP-NETs: Hematologic toxicity trends, recovery profiles, and discontinuation rates
Abstract Introduction: Lutetium-177 DOTATATE peptide receptor radionuclide therapy (PRRT) is an effective treatment for gastroenteropancreat...
Human intestinal acute graft-versus-host disease is governed by a subset of transition-like tissue-resident memory CD8+ T cells
Abstract Background: Tissue-resident memory T cells(TRM) have recently emerged as crucial cellular players for murine ac...
Earlier detection of transplant-associated thrombotic microangiopathy using harmonization criteria: A real-world comparative evaluation with conventional criteria
Abstract Aim: Transplant-associated thrombotic microangiopathy (TA-TMA) is a frequently underrecognized complication of allogeneic hematopoi...
Development and validation of a new model for predicting occult cancer after unprovoked VTE and its comparative performance against riete and some scores
Abstract Background: Venous thromboembolism (VTE) can be the first clinical manifestation of occult cancer. In our prior work, we externally...
The novel allosteric NEK7 inhibit ofirnoflast (HT-6184) reduces oxidized mitochondrial DNA in patients with low-risk myelodysplastic syndrome
Abstract Background The progression of myelodysplastic syndromes (MDS) is driven by chronic sterile inflammation within the bone marrow micr...
Tet2-associated inflammatory signaling alters healthy hematopoiesis with clonal expansion
Abstract Age-related clonal hematopoiesis (CH) is often driven by mutations in epigenetic regulators such as TET2. These mutations in epigen...
IL-4 epigenetically reprograms CART19-28ζ cells to drive dysfunction
Abstract Recent studies have highlighted the important but pleiotropic role of IL-4 in response to chimeric antigen receptor T (CART) cell t...