Blood
Articles in this Issue
Beyond the genome: An integrated multi-omics approach to uncover histone ptm-driven metabolic and proteomic regulation in AML
Abstract * Laura Corveleyn, Jolien Vanhooren and Boris Vandemoortele are shared first authors ** Vanessa Vermeirssen, Ti...
Outcomes of NPM1-mutated AMLs in first hematological relapse and prognostic value of MRD
Abstract Background & Objectives. The prognosis of NPM1m AML after first hematological relapse and the predictive value of NPM1m MRD wit...
Type 2 diabetes screening and management in individuals with sickle cell disease is compromised by the predominant reliance on glycosylated haemoglobin (HbA1c)
Abstract Coexisting diabetes mellitus and sickle cell disease (SCD) markedly increases the risk of organ damage, particularly nephropathy. A...
Impact of long-term luspatercept treatment on iron parameters in patients with transfusion-dependent and non-transfusion-dependent β-thalassemia: Results from the phase 3b long-term follow-up study
Abstract Introduction: Iron overload is a common complication of chronic anemia and ineffective erythropoiesis in β-thalassemia. Initial ana...
Tumor-derived microRNA-125a impairs CART cell function and predicts treatment failure in B cell malignancies
Abstract Background Chimeric antigen receptor T cell (CART) therapy has revolutionized treatment for hematologic malignancies. However, dura...
LS1781 (Arm E): Phase II clinical trial to assess the safety and efficacy of high dose IV ascorbic acid with decitabine in newly diagnosed TET2 mutant chronic myelomonocytic leukemia (CMML)
Abstract BACKGROUND: DNA methyltransferase inhibitors (DNMTi) are US FDA approved for the management of CMML. These agents are associated wi...
PITPβ loss disrupts malignant pAKT activation to ameliorate Jak2 V617F-induced myeloproliferative neoplasms (MPN) in mice
Abstract Myeloproliferative Neoplasms (MPN) is a group of phenotypically defined blood cancers that affect thousands of people around the wo...
Randomized phase II dose optimization study of inobrodib (CCS1477), in combination with pomalidomide and dexamethasone in relapsed/refractory multiple myeloma (RRMM)
Abstract Background Inobrodib (CCS1477/Ino) is a first-in-class potent, selective, and orally bioavailable inhibitor of the bromodomains of p...
Single-cell sequencing reveals transcriptional and metabolic divergence of bone-involved multiple myeloma
Abstract Multiple myeloma (MM) presents with heterogeneous clinical symptoms, commonly categorized as CRAB features—hypercalcemia, renal fai...
Clinical significance of dynamic changes in platelet satellitism during multiple myeloma therapy
Abstract Background: Platelet satellitism (PS) is a rare form of pseudothrombocytopenia characterized by rosette-like clusters of platelets...
Outcomes and treatment strategies following CD20/CD3 bispecific antibody failure in non-Hodgkin's lymphoma: A retrospective single-center study
Abstract Introduction Bispecific antibodies (BsAbs) targeting CD20 and CD3 have demonstrated promising efficacy in treating relapsed or refr...
Abstract: Maternal and fetal outcomes of pregnancy in essential thrombocythemia: A systematic review.
Abstract Introduction Approximately 20% of women with essential thrombocythemia (ET) are below the age of 40 with childbearing potential. Ho...
Real-world use, safety, and efficacy of teclistamab with or without prophylactic tocilizumab in relapsed/refractory multiple myeloma; Results from the danish ABCD study.
Abstract Introduction Teclistamab (Tec) is a bispecific antibody targeting BCMA and CD3 for the treatment of triple-class-exposed (TCE) rela...
Early results from the ongoing pegcetacoplan silo of the international paroxysmal nocturnal hemoglobinuria interest group registry
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, serious hematologic condition in which a somatic mutation in bone...
Evaluating the correlation between the quantra hemostasis system and rotational thromboelastometry (ROTEM) for viscoelastic hemostatic assessment: A systematic review and meta-analysis.
Abstract Introduction/Background: Perioperative and trauma-induced coagulopathy considerably contributes to morbidity and mortality. While R...
Early detection of advanced-stage DLBCL using random forest: Uncovering large-scale demographic disparities and site-specific risk patterns
Abstract Background: Advanced stage (III/IV) diffuse large B-cell lymphoma (DLBCL) at diagnosis is associated with inferior outcomes and oft...
Transformed Waldenström macroglobulinemia is associated with poor outcomes and chemorefractory disease
Abstract Background: Histological transformation (HT) of Waldenstrom Macroglobulinemia (tWM) is associated with an overall survival of less...
Asciminib as monotherapy or adjunctive therapy for chronic myeloid leukaemia in blast phase
Abstract Introduction Asciminib, a first-in-class Specifically Targeting the ABL Myristoyl Pocket (STAMP) inhibitor, has...
VYSION (VYxeoS liposomal® Italian Observational study iN the real practice): Study design and baseline characteristics
Abstract CPX-351, a dual-drug liposomal encapsulation of daunorubicin and cytarabine in a synergistic 1:5 molar ratio, was approved for newl...
Model-based evaluation of clinical outcomes for ponatinib versus 2G TKIs in third-line chronic myeloid leukemia (CML)
Abstract Background: Patients with chronic phase chronic myeloid leukemia (CP-CML) who have failed treatment with two prior tyrosine kinase...
Efficacy and safety of Daratumumab in relapse/refractory diffuse large B-cell lymphoma
Abstract Background: Daratumumab is a human immunoglobulin G1 monoclonal antibody that targets CD38 surface antigen, which is overexpressed...
Impact of hospital admissions through the emergency department versus direct admissions for patients with hematologic malignancies: A single site analysis
Abstract Introduction: Patients with hematologic malignancies often visit the Emergency Department (ED) more frequently than patients with c...
Therapeutic preclinical study on the synergy between CD73 inhibitors and selinexor for managing multiple myeloma
Abstract Abstract Background: Selinexor, a selective nuclear export inhibitor that blocks XPO1 and reduces the translation of oncoprotein mR...
Impact of radiation in limited stage diffuse large B-cell lymphoma in the modern era
Abstract Background: The current approach of limited-stage (LS) DLBCL consists of a short course of chemoimmunotherapy (3-4 cycles) followed...
Congenital dyserythropoietic anemia type I: Updated report from the congenital dyserythropoietic anemia registry of North America
Abstract Background Congenital dyserythropoietic anemias (CDA) are rare genetic disorders characterized by ineffective e...