Blood
Articles in this Issue
Phase II study of lenalidomide in combination with rituximab, cyclophosphadmie, doxorubicin, vincristine, and prenisone (R-CHOP) for central nervous system prophylaxis in high-risk diffuse large B cell lymphoma
Abstract Background Relapse of diffuse large B-cell lymphoma (DLBCL) in the central nervous system (CNS) is an uncommon but fatal event. The...
Hemostasis in crisis: Two-decade trends of mortality due to coagulation defects in the u.S. population; A CDC- wonder database analysis
Abstract Introduction: Coagulation defects, purpura, and other hemorrhagic conditions encompass a range of disorders where the blood's abili...
Extracellular arginine deprivation enhances venetoclax sensitivity in acute myeloidleukemia via mitochondrial fission impairment and apoptotic priming
Abstract Resistance to the BCL2 inhibitor venetoclax (VEN) remains a major therapeutic challenge in acute myeloid leukemia (AML), fostering...
Asxl1 mutant cells suppress Dnmt3a mutant clonal expansion.
Abstract Clonal hematopoiesis (CH) is ubiquitous among people over age 55, and 25% of aged individuals have multiple mutant clones (Fabre, N...
Health-related quality of life trajectories of patients with aggressive B-cell lymphomas treated with CAR T-cell therapy: Results from a prospective observational study
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has substantially improved survival for patients with aggressive B-Cell l...
Spatial multiomics reveal a critical role for TIM4-expressing macrophages in blast transformation of chronic myelomonocytic leukemia
Abstract The importance of bone marrow (BM) microenvironment and its immune interactions within and their role in chronic myelomonocytic leu...
Anticoagulation dilemma in a patient with nephrotic syndrome and bleeding of unknown origin: A case-based approach to risk-benefit decision-making
Abstract Introduction: Nephrotic syndrome is associated with a hypercoagulable state due to urinary loss of anticoagulant proteins and incre...
Glofitamab in combination with polatuzumab vedotin demonstrates high and durable efficacy in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) in the second-line (2L) and third-line and later (3L+) settings: A subgroup analysis
Abstract Background: Despite recent advances, R/R LBCL remains clinically challenging with poor outcomes and a critical need for effective a...
Prognostic significance of post-treatment EBV clearance and relapse patterns in localized extranodal NK/T-cell lymphoma treated with low-dose radiotherapy: A single-center analysis of 155 patients
Abstract Background: Localized extranodal NK/T-cell lymphoma (ENKTL), nasal type, is commonly treated with radiotherapy (RT) and L-asparagin...
The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation
Abstract Introduction: Belumosudil is a Rho-associated coiled-coiled (ROCK) 2 inhibitor that is approved for the treatment of chronic graft-...
Impact of TP53 mutations on survival outcomes in the CAR-t era of large b-cell lymphoma
Abstract Background: TP53 mutations are associated with poor prognosis and treatment resistance in diffuse large B-cell lymphoma (DLBCL). Chi...
Clinical outcomes following single unrelated cord blood transplantation with ATG conditioning regimen for the treatment of mucopolysaccharidosis
Abstract Abstract Objective: To evaluate the clinical efficacy of single unrelated cord blood transplantation (UCBT) with anti-thymocyte glo...
Clonal dynamics of FLT3-ITD positive acute myeloid leukemia following relapse after allogeneic stem cell transplantation
Abstract Introduction: Allogeneic stem cell transplantation (alloSCT) offers a potential cure for patients with FLT3-internal tandem duplica...
A paraspinal extramedullary hematopoiesis with cauda equina syndrome in a transfusion-dependent thalassemia patient after treatment with luspatercept: A case report.
Abstract Introduction: Thalassemia is an inherited disorder characterized by mutations in the genes responsible for the production of the al...
Is dual targeting of FXII and Gas6 a good strategy to prevent thrombosis with no risks of bleeding?
Abstract Introduction: Preventing thrombosis without increasing bleeding remains a key clinical challenge. Safer anticoagulants are being ex...
Trends and disparities in anemia and hypertensive disease-related mortality among adults aged ≥65 years in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Anemia and hypertensive diseases are common and clinically significant conditions among older adults, each independen...
Revisiting morbidities and predictors in transfusion-dependent thalassemia: A cohort study over 10 years from the national registry of hemoglobinopathies in Türkiye
Abstract Introduction National registries in hemoglobinopathies are crucial for identifying gaps between research eviden...
Outpatient palliative care utilization in adults with sickle cell disease: A trinetx-based national cohort study
Abstract Introduction: Sickle cell disease (SCD) is a chronic hematological disorder marked by complications such as recurrent vaso-occlusiv...
Salvage-free, transplantation-free survival (STFS) in AML: Proposition for a novel clinical endpoint to better assess the efficacy of novel drugs in combination with intensive chemotherapy. a dataml registry study.
Abstract IntroductionResults from pivotal clinical trials evaluating the combination of intensive chemotherapy (IC) with inhibitors of IDH1,...
Defining the clinical characteristics and outcomes of adult patients (pts) with 11q23/KMT2A-rearranged Acute Myeloid Leukemia (AML): An analysis from the MARROW consortium
Abstract Background: 11q23/KMT2A rearrangements (11q23/KMT2A-r) are associated with a poor prognosis and a high risk of relapse when treated...
Outcomes with ATO/ATRA based regimen in apml - steroid induced toxicities are a concern in LMICs
Abstract Background: ATO/ATRA forms the backbone of induction therapy in the treatment of APML. However, its use is frequently associated wit...
Human iPSC-derived bone marrow organoids for AML engraftment and immunotherapy testing
Abstract Acute myeloid leukemia (AML) is associated with complex treatment challenges and persistently poor outcomes. Leukemic stem cells ar...
Longitudinal clonotype tracking by next-generation sequencing (NGS) based T-cell receptor (TCR) rearrangement measurable residual disease (MRD) assay in frontline adult T-acute lymphoblastic leukemia (ALL)
Abstract Introduction: Use of NGS assays based on IGH B-cell receptor (BCR) gene rearrangement has been a major advance...
Enhancing the prediction of CD34+ cells yield in autologous stem cell collection using complete blood count and clinical information: A quality improvement initiative spanning 4.5 years of data from a tertiary academic center
Abstract Background:Autologous stem cell transplant (ASCT) is an important treatment for various hematologic and non-hematologic diseases. I...
Updated clinical data and biomarker analyses from the phase 1 study of DR-01, a non-fucosylated anti-CD94 antibody in patients with relapsed/refractory cytotoxic lymphomas
Abstract Introduction: DR-01 is a non-fucosylated human IgG antibody targeting CD94, expressed on terminal effector CD8+T cells, γδT cells, a...