Blood
Articles in this Issue
Outcomes of hospitalized patients with hyperferritinemia and hematologic malignancies: A single-center retrospective analysis
Abstract Background Hyperferritinemia is associated with systemic inflammation and adverse clinical outcomes. Its prognostic significance in...
Real-world outcomes associated with azacitidine and venetoclax in Myelodysplastic Syndromes
Abstract Introduction: Myelodysplastic syndromes (MDS) are hematologic malignancies characterized by bone marrow failure and risk for progre...
Talquetamab bridging therapy for B-cell maturation antigen chimeric antigen receptor T-cell in Relapsed/Refractory multiple myeloma
Abstract Introduction: Bridging treatment prior to administration of chimeric antigen receptor (CAR) T-cells in patients with relapsed/refra...
Evaluating the implementation of an electronic patient-reported outcome system supporting self-management of treatment-related impairments among patients with lymphoma
Abstract Introduction: Patients treated for lymphoma often experience a high burden of treatment-related impairments that, when left unaddre...
iPSC-derived mesenchymal stromal cells (iMSC) provide superior support for hematopoietic reconstitution compared to BM-MSCs
Abstract Background Mesenchymal stromal cells (MSCs) have demonstrated therapeutic promise in regenerative medicine and hematopoietic suppor...
Generation of iNKT cells with hematopoiesis-promoting properties from human iPSCs
Abstract Human invariant natural killer T (iNKT) cells are a conserved population of innate-like T cells that are activated by glycolipid an...
Preclinical efficacy of dual BET/HAT inhibitor–based combinations against post myeloproliferative neoplasm secondary AML cells
Abstract In MPN stem/progenitor cells, the co-occurrence of additional mutations in chromatin/transcriptional regulators such as DNMT3A, ASX...
Pharmacodynamic analysis of AGAVE-201 indicates changes in CSF-1R–expressing cells and associated biomarkers potentially contributing to chronic graft-versus-host disease resolution
Abstract Introduction: Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and nonrelapse mortality among patients who u...
Hematologic malignancies in pediatric patients with RUNX1-familial platelet disorder with associated myeloid malignancy
Abstract RUNX1 is a transcription factor crucial for normal hematopoiesis. Deleterious germline RUNX1 variants cause Familial Platelet Disor...
Baseline T-cell fitness and subtype-specific CD19 loss as drivers of blinatumomab resistance in B-ALL
Abstract The introduction of Blinatumomab (BLIN), a bispecific T-cell engager targeting CD19, has marked a major advancement in B-ALL therap...
Whole genome sequencing of cell-free DNA for assessment of minimal residual disease in high-risk smoldering multiple myeloma
Abstract Introduction In multiple myeloma (MM), assessment of minimal residual disease (MRD) is limited by a need for serial bone marrow (mar...
Travel time and insurance status as determinants of specialized leukemia care access in adolescents and young adult (AYA) patients with acute lymphoblastic leukemia (ALL)
Abstract Background: NCCN guidelines for ALL state that patients should undergo evaluation and treatment at specialized [cancer] centers (SC...
Pyruvate kinase deficiency is associated with mitochondrial retention, decreased antioxidant and HIFs activity correlating with hemolysis
Abstract Pyruvate kinase deficiency (PKD), caused by loss-of-function mutations in the PKLR gene, is a rare autosomal recessive disorder but...
Pilot of standardized cognitive behavioral therapy for young adults with sickle cell disease
Abstract The success in minimizing sickle cell disease (SCD) morbidity in pediatrics has often been difficult to maintain upon moving to adu...
Single-cell transcriptomic analysis reveals ifng/IL-6-mediated inflammatory networks in der(1;7)(q10;p10) Myelodysplastic Syndromes
Abstract Background: Der(1;7)(q10;p10)[der(1;7)] as a recurrent unbalanced translocation in MDS has steadily gained attention. The direct co...
Response-adapted randomization to Q2W vs Q4W isatuximab beyond cycle 6 in relapsed multiple myeloma: Results from a phase 2 Study of isa-pd in lenalidomide- and PI-exposed patients
Abstract Introduction: Isatuximab (Isa), an anti-CD38 mAb, is approved with pomalidomide and low-dose dexamethasone (Isa-Pd) for RRMM after ≥...
Gene expression profiling of pediatric mature B-cell non-Hodgkin lymphomas/lymphoproliferative disorders through whole transcriptome analysis
Abstract Background: Adult and pediatric mature B-cell non-Hodgkin lymphomas/lymphoproliferative disorders (ped mature B-NHL/LPDs) differ bo...
The unseen bleed- temporal and demographic patterns of thrombocytopenia mortality in the United States: A 25-year analysis of the CDC wonder database
Abstract The Unseen Bleed- Temporal and Demographic Patterns of Thrombocytopenia Mortality in the United States: A 25-Year Analysis of the C...
Feasibility and preliminary efficacy of a Mediterranean diet and home-based exercise intervention during chemotherapy for lymphoma survivors: The life-l study
Abstract Introduction: Lymphoma patients undergoing chemotherapy often face toxicities that affect treatment completion and quality of life....
Incidence, predictors and consequences of poor graft function after post-transplant cyclophosphamide (PTCy)-based allogeneic transplantation
Abstract Prolonged cytopenias requiring transfusion and growth factor support are a known complication of allogeneic hematopoietic stem cell...
Safety and efficacy of linvoseltamab as a simplified monotherapy first-line regimen in NDMM: Initial Results from the window of opportunity Phase 1/2 LINKER-MM4 trial
Abstract Introduction Treatment of NDMM relies on complex quads and triplets, highlighting a need for a simpler, improved regimen. LINVO, a...
Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia
Abstract There are fundamental differences in the genomic drivers of childhood, adolescent and young adult (AYA) acute myeloid leukemia (AML...
Extreme thrombocytosis in patients with underlying malignancy; Management, complications and outcomes.
Abstract Thrombocytosis is a commonly seen haematological abnormality. However, extreme thrombocytosis (EXT, defined as a platelet count of...
Pre-existing cognitive impairment is associated with reduced long-term survival following chimeric antigen receptor T-cell therapy for non-Hodgkin's lymphoma
Abstract Introduction: CAR T therapy has revolutionized treatment landscape for patients with relapsed refractory (R/R) non-Hodgkin's lympho...
Impact of a near-peer group mentorship program on improving transition skills for adolescents and young adults living with sickle cell disease
Abstract Introduction People living with sickle cell disease (SCD) often have short life expectancies and are deeply aff...