Blood
Articles in this Issue
Targeting the sanctuary sites: Allogeneic CD19 CAR-T therapy for extramedullary relapsed B-cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation
Abstract Background: For patients with B-cell acute lymphoblastic leukemia (B-ALL), extramedullary relapse after allogen...
A novel intercontinental external quality assessment program for flow cytometric measurable residual disease assessment in pediatric AML
Abstract Background Assessment of measurable residual disease by multidimensional flow cytometry (MFC-MRD) is critical f...
Engineered IL7/IL15 secreting iPSC-derived mesenchymal stromal cells reprogram the immunosuppressive tumor microenvironment and potentiate antitumor immunity
Abstract Mesenchymal stromal cells (MSCs) derived from bone marrow (BM-MSCs) exhibit inherent tumor-tropic behavior, directed by chemotactic...
Thyroid diffuse large B-cell lymphoma in China: Multicenter study of diagnosis, clinical features, treatment efficacy, prognostic factors, and genomic alterations
Abstract Objective: To investigate the clinicopathological characteristics, genomic mutational profiles, prognostic determinants, survival...
Elevated aPTT in the setting of prophylactic unfractionated subcutaneous heparin administration
Abstract Subcutaneous unfractionated heparin or low-molecular-weight heparin is commonly used for venous thromboembolism prophylaxis in hosp...
Access to acute promyelocytic leukemia treatment in New York City
Abstract Introduction Acute promyelocytic leukemia (APL) is a medical emergency that requires urgent administration of a...
Utilization and cost trends of topical mechlorethamine for cutaneous T-cell lymphoma in the United States: A Medicare part d analysis
Abstract Background: Valchlor (mechlorethamine gel) is a topical chemotherapy used to treat cutaneous T-cell lymphoma (CTCL). Despite its we...
Comparing the diagnosis, disease, and treatment experience of essential thrombocythemia from clinicians' and patients' perspectives: Insights from a qualitative interview study in the United States
Abstract Background: Essential thrombocythemia (ET) is a rare, chronic myeloproliferative neoplasm marked by an overproduction of platelets,...
The mitochondrial protease YME1L regulates type 1 interferon signaling via the cgas-sting pathway in AML
Abstract Yeast Mitochondrial Escape 1-Like 1 (YME1L) is an inner mitochondrial membrane–anchored ATP-dependent metalloprotease. Here, we inv...
Bendamustine combined with fludarabine/cyclophosphamide as a enhanced lymphodepletion regimen demonstrates favorable efficacy and safety in CAR-T therapy for extranodal/bulky R/R B-cell lymphoma
Abstract Introduction： Bulky disease has been identified as an independent predictor of poor outcomes following CAR-T therapy. Although lym...
Xgboost profiling of quantitative lymph-node and symptom signatures distinguishes idiopathic multicentric castleman disease and its clinical subtypes
Abstract Background: Idiopathic multicentric Castleman disease (iMCD) is a rare disorder involving multifocal lymphadenopathy, systemic infl...
Production of lab-grown red blood cells in hollow fiber bioreactors
Abstract Lab-grown red blood cells (lgRBCs) hold significant promise for supplementing transfusion needs and serving as vehicles for drug de...
Favorable safety and efficacy in a phase II trial using duvelisib maintenance after autologous stem cell transplant in T-cell and B-cell non-Hodgkin lymphomas
Abstract Introduction Peripheral T-cell lymphoma (PTCL) is a rare, aggressive group of non-Hodgkin lymphomas (NHL), including PTCL-not other...
The real-world safety and efficacy of bispecific t-cell engager therapy in systemic AL amyloidosis
Abstract Introduction: The attainment of rapid and deep hematologic responses is key to restoring organ function and reducing mortality in A...
MCL1 copy number gain is a recurrent mark of venetoclax resistance in patients with chronic lymphocytic leukemia
Abstract Introduction. The advent of the BCL2 inhibitor (BCL2i) venetoclax (VEN) has been transformative for patients with chronic lymphocyti...
Ianalumab retreatment in adults with primary immune thrombocytopenia (ITP) or warm-antibody autoimmune hemolytic anemia (wAIHA) who benefitted from previous ianalumab treatment: A phase 2 exploratory study
Abstract Background: Immune thrombocytopenia (ITP) is a rare, acquired, immune-mediated disease characterized by a decrease in platelet coun...
Patient-informed CRISPR screening reveals gene targets to improve CAR T-cell efficacy
Abstract Background: Chimeric Antigen Receptor (CAR) T-cell therapy targeting CD19 has transformed outcomes for patients with relapsed and r...
Axicabtagene ciloleucel versus tisagenlecleucel in relapsed or refractory diffuse large B-cell lymphoma
Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment of relapsed or refractory (R/R) dif...
Cryo-electron tomography of sickled red blood cells towards a high-resolution in situ structure of HbS polymers and red cell cytoskeleton
Abstract Sickle Cell Disease (SCD) is an inherited red cell disorder caused by the presence of the abnormal hemoglobin S (HbS) resulting fro...
VTE risk in transgender women on estrogen therapy: A review of formulation-specific risks, management strategies, and evidence gaps
Abstract Background: Transgender women benefit significantly from gender-affirming hormone therapy (GAHT), particularly estrogen, which impr...
A novel prognostic scoring system incorporating XPO1 for primary central nervous system lymphoma.
Abstract Objective: To identify and validate prognostic protein biomarkers for primary central nervous system lymphoma (PCNSL) and develop a...
Sequential therapy with fitcy preparative regimen for patients above the age of 70 years with active AML – a single center retrospective analysis
Abstract Introduction - Patients aged over 70 years with relapsed or refractory acute myeloid leukemia (AML) have an extremely poor prognosi...
Effectiveness and safety profile of pola-based regimen in DLBCL Patients with high-risk factors in real world: A retrospective study in China
Abstract Background Polatuzumab vedotin, an antibody-drug conjugate targeting CD79b, has become the standard of care (SOC) for both treatmen...
Cyclin D1 immunostaining as a diagnostic surrogate for the t(11;14) translocation in AL amyloidosis
Abstract Introduction The chromosomal translocation t(11;14)(q13;q32), which juxtaposes the cyclin D1 (CCND1) and the im...
Concizumab efficacy in patients with Hemophilia A/B without inhibitors from the Phase 3 explorer8 study: A post-hoc sensitivity analysis for the intra-patient comparison of concizumab with previous prophylaxis
Abstract Background Concizumab is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody indicated for hemophilia A/B with/witho...