Blood
Articles in this Issue
RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy
Abstract Background: Multiple myeloma (MM) remains incurable despite therapeutic advances, necessitating novel treatment strategies. Ferropto...
Impact of DUSP22 and TP63 rearrangements in patients with ALK-negative ALCL treated with frontline BV-CH(E)P
Abstract Background: DUSP22- and TP63-rearranged ALK- ALCL are distinct genetic subtypes with unique disease phenotypes and reported variabi...
Post-transplant cyclophosphamide significantly reduces early non-relapse mortality following allogeneic hematopoietic cell transplantation
Abstract Introduction Survival following allogeneic hematopoietic cell transplantation (allo-HCT) has improved over the last several decades...
Heterogeneity of immune escape mechanisms in de novo Acute Myeloid Leukemia
Abstract Acute Myeloid Leukemia (AML) is a malignancy of hematopoietic stem/progenitor cells. Although immune checkpoint blockade has been e...
Transcriptional profiling refines DLBCL classification and identifies subtypes with distinct therapeutic vulnerabilities
Abstract Introduction: Genetic classification of diffuse large B-cell lymphoma (DLBCL) using LymphGen (LG) has provided critical insights in...
Developing SEMA4A-directed CAR t cells to overcome low BCMA antigen density in multiple myeloma
Abstract Chimeric antigen receptor (CAR) T cell therapies targeting B cell maturation antigen (BCMA) have shown unprecedented activity in pa...
Real-world treatment patterns and clinical outcomes of therapies in primary immune thrombocytopenia
Abstract Introduction: Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by low platelet counts, leading to a wide s...
Recurrent loss of chromosome y in multiple myeloma is linked to disease progression and altered tumor immune microenvironment
Abstract Introduction Sex-based disparities in multiple myeloma (MM) are well established, with men being more commonly affected than women,...
Safety and activity of gene therapy with AAV8 GBA1 (LY-M001)on type I adults gaucher disease
Abstract Background: Gaucher disease (GD) is a rare autosomal recessive disorder caused by GBA1 mutations, leading to deficient glucocerebro...
Real-world practices in the management of pediatric iliofemoral deep vein thrombosis, results of the elite-kids survey from the CHAT consortium
Abstract Background Deep vein thrombosis (DVT) of the extremities is the most common presentation of venous thromboembolism (VTE) in childre...
Torque teno virus in pediatric CAR-T recipients
Abstract BACKGROUND Chimeric antigen receptor T-cell (CART) therapy has improved outcomes in relapsed/refractory (R/R) patients with B-acute...
Identifying patients with indolent Acute Myeloid Leukemia: Long term survivors after best supportive care only, results from the pethema registry
Abstract Introduction: Most patients with acute myeloid leukemia (AML) who receive palliative best supportive care (BSC) alone experience po...
A proteomics-driven machine learning tool for distinguishing ET from pre-PMF
Abstract Background: Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are clinically overlapping but biologica...
Cellpolaris: A novel tool to quantify cell polarity reliably at scale in fixed and living cells
Abstract Cell polarity, the asymmetric distribution of cellular constituents, is critical for many cellular functions, including cell migrat...
Real-world validation of ELN2024 and BEAT-AML2024 risk-stratification in patients with Acute Myeloid Leukemia unfit for intensive chemotherapy in a multicenter italian cohort.
Abstract Introduction: Acute myeloid leukemia (AML), a clonal neoplastic disease, mainly affects older adults, peaking at age 68, with two-t...
Survival after first relapse of pediatric B-ALL differs by insurance type: A real-world analysis from the recall-1 study
Abstract BACKGROUND Children exposed to poverty during frontline therapy for B-lymphoblastic leukemia (B-ALL) experience inferior overall su...
Dissecting pirtobrutinib resistance in Mantle Cell Lymphoma through single-cell multi-omics
Abstract Introduction Although the non-covalent BTK inhibitor Pirtobrutinib (PBN) has demonstrated clinical efficacy in treating relapsed an...
Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy
Abstract Introduction: Extramedullary disease in multiple myeloma (EMD) is a clinically aggressive variant of multiple myeloma (MM), frequent...
Clinical implications and prevalence of benign ethnic neutropenia (BEN) in lymphoma patients of middle eastern ethnicity
Abstract Background Benign ethnic neutropenia (BEN) commonly affects patients of African and Middle Eastern descent, and does not represent...
ARV-393, a PROTAC BCL6 degrader, combined with the CD20×CD3 bispecific glofitamab in a preclinical model of high-grade B-cell lymphoma (HGBCL)
Abstract Background: Despite significant progress made in the treatment of non-Hodgkin lymphoma (NHL) through advancements with immunochemot...
FLT3 ligand facilitates long-term ex vivo expansion of human hematopoietic stem cells by maintaining lymphoid reconstitution potential
Abstract Hematopoietic stem cells (HSCs) are blood-forming stem cells that can reconstitute the entire blood system after transplantation, w...
Temporal trends in mortality due to Acute Myeloid Leukemia and sepsis in u.S. adults aged ≥25 years (1999–2023): A CDC wonder database analysis
Abstract Introduction: Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy affecting approximately 22,0...
Association of red blood cell transfusion and clinical outcomes in chimeric antigen receptor T-cell therapy: Insights from a six-year nationwide analysis
Abstract Background Chimeric Antigen Receptor (CAR) T-cell therapy has transformed the treatment paradigm for relapsed o...
Epitranscriptomic signatures define prognosis and therapeutic vulnerabilities in large B-cell lymphoma
Abstract Introduction: Large B-Cell Lymphoma (LBCL) is an aggressive and the most common non-Hodgkin lymphoma, accounting for 30% of cases....
Modeling of a hyper-inflammatory hematopoietic niche ex vivo reveals a multi-step process driving CAR T- cell associated myeloid leukemia in multiple myeloma
Abstract Introduction: Although prior exposure to mutagenic agents like melphalan and lenalidomide is a known risk facto...