Blood
Articles in this Issue
Alphagenome-enabled analysis of non-coding regulatory variants underlying rhd expression
Abstract Introduction RhD is a critical blood group antigen associated with hemolytic transfusion reactions and fetal/newborn disease. While...
The importance of MRI in diagnostic workup of smoldering multiple myeloma
Abstract Background In 2014, the International Myeloma Working Group (IMWG) revised the diagnostic criteria for multiple myeloma (MM), incor...
Effect of plasmapheresis on mortality and length of stay in hospitalized patients with thrombotic thrombocytopenic purpura
Abstract Background Thrombotic Thrombocytopenic Purpura (TTP) is a rare and serious thrombotic microangiopathy that's defined by the confirm...
Optimizing high-dose methotrexate treatment regimens to improve exposure and mitigate toxicity in infant patients with acute lymphoblastic leukemia
Abstract Introduction: High-dose methotrexate (HDMTX) is a key component of therapy for high risk acute lymphoblastic leukemia (ALL). Typica...
Integrated prognostic model for TP53‑mutated myeloid neoplasms across all myeloid neoplasm subtypes
Abstract Background: TP53-mutated myeloid neoplasms (MNs) represent one of the most lethal subgroups of blood cancers. The World Health Orga...
The charlson comorbidity index as a predictor of survival in peripheral T-cell lymphoma: A multicenter analysis from the gifu hematology study group
Abstract Background: Peripheral T-cell lymphoma (PTCL) is one of the most aggressive subtypes of non-Hodgkin's lymphoma, with a 5-year survi...
Impact of TP53 mutation on CD19-chimeric antigen receptor T-cell therapy in large B-cell lymphoma
Abstract Introduction: Although CD19-targeted chimeric antigen receptor T-cell (CD19-CAR-T) therapy is highly effective in relapsed or refra...
Comparison of infectious complications in patients with relapsed/refractory large B-cell lymphoma receiving CAR T cells vs bispecific antibodies
Abstract INTRODUCTION: T-cell redirecting strategies (TRS), including chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsA...
Zanubrutinib maintenance post-autologous stem cell transplantation in Mantle Cell Lymphoma: A prospective multicenter Phase II trial
Abstract Introduction Autologous stem cell transplantation (ASCT) is a potent treatment to improve the prognosis of mantle cell lymphoma (MC...
Pharmacodynamic activity and clinical benefits of mezigdomide in high-risk biomarker subgroups from the CC-92480-MM-001 study
Abstract Introduction: Mezigdomide (MEZI) is an oral CELMoD™ agent that induces rapid and potent degradation of lkaros and Aiolos. Reduction...
Interim analysis of a Phase I/II study of tafasitamab with lenalidomide in patients with relapsed central nervous system lymphoma
Abstract Introduction The development of novel, effective and well-tolerated biological strategies to treat primary and secondary CNS lympho...
Real-world survival of IDH-mutant patients in China before IDH-inhibitor era: A multicenter retrospective study from anhui cooperative hematology group(ACHG)
Abstract The impact of IDH mutations on the survival of AML patients is unclear. Since the VIALE-A study shows improved survival for patient...
Impact of pomalidomide-containing induction chemotherapy on hematopoietic stem cell mobilization in multiple myeloma: A retrospective cohort study
Abstract Introduction Pomalidomide (POM), a potent immunomodulatory agent, is increasingly used in multiple myeloma (MM). Preclinical data s...
Sepsis in Acute Myeloid Leukemia (AML) patients: A 407,095-patient national inpatient sample study (2016-2022)
Abstract Introduction Sepsis is a leading cause of morbidity and mortality in patients with cancer, but its impact in acute myeloid leukemia...
Factor XI haploinsufficiency is protective against venous thromboembolism and myocardial infarction in population-scale multidimensional datasets
Abstract Background: Coagulation factor XI (FXI, F11) inhibitors are a novel antithrombotic strategy that may carry a lower risk of spontane...
HMGA1 chromatin regulators drive transcriptional networks involved in megakaryocyte expansion, fibrosis, and sensitivity to interferon signaling in JAK2-V617F MPN
Abstract Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders with an increased risk of trans...
Enhancing hemostasis in glanzmann thrombasthenia via protein S inhibition
Abstract Introduction: Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder caused by a deficiency of the platelet...
CAR-T cell therapy in multiple myeloma in a front-line setting: A systematic review and meta-analysis
Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy targeting the B-cell maturation antigen (BCMA) has consistently prod...
Talquetamab in Relapsed/Refractory multiple myeloma with renal impairment: A quaternary cancer center experience
Abstract Introduction Patients with relapsed/refractory multiple myeloma (RRMM) and renal impairment (RI) represent a high-risk group freque...
A case series on cutaneous reactions to ivig
Abstract Intravenous immunoglobulin (IVIg) is increasingly utilised to treat a wide spectrum of indications. While generally well-tolerated,...
Development of whole blood viscosity measurements under hypoxia for use in sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is an inherited blood disorder caused by an amino acid change that prod...
Molecular determinants of outcome in CLL patients treated on zanubrutinib registration trials
Abstract Background: Critical barriers to precision medicine in CLL include molecular heterogeneity of the disease and limited availability...
A phase I study of venetoclax in combination with multiagent cytotoxic chemotherapy for children and adolescents with relapsed or refractory acute lymphoblastic leukemia or mixed phenotype acute leukemia: Results of the dose determination cohort
Abstract Background Relapse is the most common cause of treatment failure for children and adolescents with acute lymphoblastic leukemia (AL...
Acute myeloid leukemias with UBTF tandem duplications respond to combined BCL-2 and RNA polymerase I inhibition with increased stemness and a quiescent-like state
Abstract Acute myeloid leukemia (AML) with tandem duplications in the upstream binding transcription factor gene (UBTF-TD) has recently been...
Age-specific impact of apoptosis gene expression and recurrent mutations on remission and survival in AML: A machine learning-based analysis
Abstract Patient's age remains one of the most important prognostic factors in acute myeloid leukemia (AML), but the extent to which age inf...