Blood
Articles in this Issue
Organ dysfunction in pediatric patients with HSCT-TMA treated with ravulizumab
Abstract Background: Hematopoietic stem cell transplantation–associated thrombotic microangiopathy (HSCT-TMA) is a life-threating complicati...
Chemo ± immunotherapy remains utilized for chronic lymphocytic lymphoma in the real-world practice: Unmet needs, treatment patterns, and age disparities in the United States
Abstract Introduction Real-world data on how chronic lymphocytic lymphoma (CLL) therapies are utilized in diverse populations provide insigh...
Geographic, demographic, and temporal disparities in mortality from hematological cancers with renal failure among u.S. adults aged ≥25 years (1999-2023): A CDC wonder analysis
Abstract Background: Hematological cancers (HC), including leukemia, lymphoma, and multiple myeloma often contribute to renal failure (RF) d...
Non-cancer related deaths in myeloproliferative neoplasm and Myelodysplastic Syndromes : A populaton based analysis
Abstract Introduction Myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) are clonal hematologic diseases characterized b...
Baseline findings to inform quality improvement opportunities in low-risk Myelodysplastic Syndromes
Abstract Background: Low-risk myelodysplastic syndromes (MDS) are heterogeneous hematologic disorders often presenting with anemia and fatig...
Single-cell genotyping and methylome sequencing (scGEM-seq) resolves cell-states and clonal hierarchies in leukemia
Abstract Leukemia evolution is driven by a complex interplay between somatic mutations and epigenetic changes. However, our understanding of...
IDH1 mutation predicts response and survival in treatment-naïve Acute Myeloid Leukemia patients receiving with venetoclax with a hypomethylating agent
Abstract Introduction Venetoclax + hypomethylating agent (Ven-HMA) is currently the standard frontline therapy for older/unfit patients (pts...
Donor-derived CAR-T cells co-infused with the allogenic graft on the platform of T cell depletion or post-transplant cyclophosphamide in children with advanced B-cell neoplasms
Abstract Introduction Autologous chimeric antigen receptor (CAR) T cells induce high rate of deep remissions among children with relapsed/re...
Pirtobrutinib versus usual care for patients with richter transformation of chronic lymphocytic leukemia: Inverse probability of treatment weighting-based analysis of BRUIN trial and mayo observational cohort
Abstract Introduction: Pirtobrutinib, a highly selective non-covalent BTK inhibitor, demonstrated encouraging efficacy in Richter transforma...
Clinical analysis of central nervous system leukemia in patients with Acute Myeloid Leukemia
Abstract Background: Central nervous system leukemia (CNSL) represents a rare but severe complication of acute myeloid l...
Targeting DNA repair vulnerabilities to eradicate TP53 mutated AML.
Abstract Mutations in TP53 (TP53mut) confer an adverse prognosis in AML. Current treatment strategies, including conventional chemotherapy,...
Single CAR-t infusion during front-line consolidation induces deep and sustained remission in newly diagnosed adult ph+b- ALL: A prospective phase 2 study
Abstract Abstract： Background: Frontline treatments combining immunotherapy, particularly blinatumab, with tyrosine kinase inhibitors (TKIs...
Real-world outcomes and toxicities of elranatamab (ELRA) in relapsed/refractory multiple myeloma: A retrospective analysis using the trinetx global health research network.
Abstract Background: Elranatamab (ELRA), a bispecific antibody targeting BCMA and CD3, has demonstrated clinical efficacy in relapsed/refrac...
Hetrombopag for enhancing platelet engraftment after haploidentical allogeneic hematopoietic stem cell transplantation in patients with severe thalassemia: An observational study
Abstract Introduction: Patients with severe thalassemia undergoing haploidentical allogeneic hematopoietic stem cell transplantation (haplo-...
Diagnostic challenges in systemic light chain( AL) amyloidosis: A retrospective evaluation of biopsy yeild and typing strategies in an Indian tertiary care centre
Abstract Introduction: Amyloidosis comprises a heterogeneous group of protein misfolding disorders characterized by the...
Academic cancer programs deliver improved long-term survival in nodular lymphocyte predominant Hodgkin lymphoma: Insights from 7,000+ United States patients
Abstract Background Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma (HL), accounting for only...
Racial disparities in sepsis-related complications among hospitalized patients with Myelodysplastic Syndromes: A national inpatient sample analysis (2016–2022)
Abstract Background: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopeni...
Novel mechanistic insights for IRAK1 and IRAK4 signaling provide a framework for the development of dual IRAK1 and IRAK4 protacs for MYD88 mutated lymphomas.
Abstract Background: MYD88 mutations are found in patients with various B-cell cancers including Waldenstrom's Macroglobulinemia (WM; 95-97%...
BCMA CAR T-cell therapy in newly diagnosed primary plasma cell leukemia ineligible for transplantation: An open label, single-arm, phase 2 study (CAREMM-002)
Abstract Background: Primary plasma cell leukemia (PPCL) is the most aggressive subtype of plasma cell neoplasms. Following the recent revis...
Real-world treatment and outcomes of Mantle Cell Lymphoma in Latin America: A multinational cohort analysis
Abstract Background: Mantle cell lymphoma (MCL) is a rare, aggressive B-cell malignancy with heterogeneous clinical behavior and poor long-te...
Short-term outcomes of rituximab versus thrombopoietin receptor agonists in Myelodysplastic Syndromes: A 90-day propensity-matched analysis using real-world data
Abstract Background: Thrombocytopenia in myelodysplastic syndromes (MDS) is associated with an increased risk of bleedin...
Efficacy of a second allogeneic hematopoietic cell transplant in myeloid heematologic malignancies
Abstract Purpose To evaluate the efficacy and safety of second allogeneic hematopoietic cell transplant (allo-HCT) in patients with myeloid...
Effects and interferences of NXT007, a novel bispecific antibody, on coagulation assays
Abstract Background: NXT007 is a bispecific antibody that mimics the function of activated factor (F)VIII and is currently in clinical devel...
Activity of autologous anti-CD19 chimeric antigen receptor T-cell therapy in CD19-negative large B-cell lymphoma: A cell therapy consortium real world experience
Abstract Introduction Pivotal trials that led to the approval of autologous anti-CD19 CAR T-cell therapy (CART) either e...
Characteristics, genomic landscape, and prognostic impact of trisomy 8 on contemporary outcomes in patients with newly diagnosed Acute Myeloid Leukemia (AML)
Abstract Background: Trisomy 8 (+8) is a recurrent cytogenetic (CG) abnormality in acute myeloid leukemia (AML), occurring either as a sole...