Blood
Articles in this Issue
Celfib-AI: A machine learning model to predict bone marrow fibrosis and cellularity from complete blood count – a multicenter model development and validation study in France
Abstract Introduction Bone marrow biopsy is an essential component of the WHO diagnostic criteria for myeloproliferative neoplasms (MPNs). Ho...
The heme pathway: A possible metabolic target for the treatment of hematologic cancers
Abstract Hematologic malignancies constitute a diverse group of diseases, each characterized by distinct pathophysiological features. These...
Dogs with acute leukemia have shared and unique genetic mutations compared to human acute leukemia
Abstract Introduction: Acute leukemia represents a heterogeneous group of aggressive hematopoietic malignancies in humans, broadly encompass...
Outcomes following MRD relapse in AML patients monitored by droplet digital PCR
Abstract Introduction: European Leukemia Network (ELN) guidelines recommend PCR-based measurable residual disease (MRD) monitoring for patie...
Prospective assessment of measurable residual disease kinetics in intensively treated patients with Acute Myeloid Leukemia (AML) - results of the PALG-AML1/2016 study
Abstract BACKGROUND: Measurable residual disease (MRD) is an important biomarker in AML. Detectable MRD (MRD+) after 2 cycles of intensive c...
Characteristics and outcomes in Acute Myeloid Leukemia with Mecom rearrangement treated with hypomethylating agent plus venetoclax
Abstract Background: Acute myeloid leukemia with MECOM rearrangement (MECOMr AML) represents 1-2% of AML and is associated with poor long-te...
Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database
Abstract Background Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis and periph...
PRC2-regulated glycolysis-to-oxphos metabolic switch coordinates the onset of terminal erythropoiesis
Abstract Erythropoiesis is a complex, tightly regulated process involving sequential changes in epigenetics, metabolism, and proliferation....
Impact of rilzabrutinib on gene-expression of inflammatory factors in patients with warm autoimmune hemolytic anemia who participated in the Phase 2B lumina 2 study
Abstract Introduction: Warm autoimmune hemolytic anemia (wAIHA) is a rare form of anemia caused by the destruction of red blood cells (RBC)...
Maintenance therapy discontinuation for patients diagnosed with multiple myeloma without high-risk features in minimal residual disease (MRD) negative remission: An interim analysis
Abstract Background: Continuous maintenance therapy is a standard practice for many physicians treating multiple myeloma (MM). Lenalidomide...
A case for CD38 targeted therapy in multi-refractory immune thrombocytopenia
Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by autoantibody-mediated platelet destruction and bleeding co...
Sustained efficacy of zanubrutinib (zanu) vs bendamustine + rituximab (BR) in treatment (tx)-naive chronic lymphocytic leukemia/small lymphocytic lymphoma (TN SLL/CLL) and continued favorable survival in non-randomized patients (pts) with del(17p): 6-year follow-up in the phase 3 SEQUOIA study
Abstract Introduction: The SEQUOIA study (NCT03336333) evaluated zanu, a next-generation Bruton tyrosine kinase (BTK) inhibitor, in TN CLL/S...
1,200+ U2AF1 mutations reveal distinct clinicobiological features of the S34/Q157 co-mutation subgroup
Abstract Background: The U2AF1 spliceosome gene recurrently acquires S34 (predominantly S34F/Y) and Q157 (primarily Q157P/R) mutations in mye...
Influenza as a less commonly recognized cause of hemophagocytic lymphohistiocytosis: A systematic review of case reports and case series
Abstract Introduction Hemophagocytic Lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory condition that c...
Molecular genetics configuration of chronic myeloid leukemia
Abstract Background: Chronic myeloid leukemia (CML) represents roughly 20% of all leukemia cases in adults, being the most common chronic my...
P-selectin blockade effectively prevents trauma-induced microvascular obstruction
Abstract Background: Trauma is a leading cause of morbidity and mortality worldwide. Although many patients survive the initial blood loss,...
Molecular profiling of lupus b cells reveals expansion of somatic mutations in lymphoma-related pathways
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by sustained immune activation, disrupted B cell t...
CD48 as an additional marker for measurable residual disease assessment in pediatric Acute Myeloid Leukemia.
Abstract Background Multidimensional flow cytometry-based measurable residual disease (MFC-MRD) assessment is an essenti...
Real-world effectiveness of romiplostim N01 with or without TPO-RA for cancer therapy-induced thrombocytopenia in cancer patients
Abstract Background: Cancer therapy-induced thrombocytopenia (CTIT) refers to thrombocytopenia occurring in cancer patients as a result of a...
Exacerbation of anemia from hereditary spherocytosis during pregnancy: Characterization of severity and use of medical interventions
Abstract Background: Hereditary spherocytosis (HS) is a congenital hemolysis that worsens during pregnancy. The extent and the timing of ane...
Danicopan add-on therapy demonstrates positive efficacy and safety outcomes in advanced age adults with paroxysmal nocturnal hemoglobinuria and clinically significant extravascular hemolysis: A sub-analysis of the phase 3 ALPHA trial
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder characterized by intravascular hemolysis, thrombosis,...
Metabolomic and epigenetic signatures of hemin-induced stress in sickle cell erythroblasts
Abstract Introduction: Patients with sickle cell disease (SCD) endure systemic hypoxia and chronic hemolysis, resulting in excessive heme ex...
Automated subtype classification of acute leukemia from bone marrow smears using a cross-platform deep learning model
Abstract Introduction: Accurate morphological classification of acute leukemia (AL) subtypes from bone marrow smears (BMSs) remains a corner...
Navigating hematology and medical oncology fellowship websites: A comprehensive review and implications for applicants
Abstract Background: With over 1.9 million new cancer diagnoses annually and better cancer survival in the United States, the demand for Acc...
Modeling discordant cardiac and renal recovery trajectories in AL amyloidosis using interpretable machine learning
Abstract Background In systemic light chain (AL) amyloidosis, hematologic remission does not guarantee organ recovery. Discordance between h...