Proceedings of the National Academy of Sciences
Articles in this Issue
Retraction for Mondal et al., IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE
Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection
Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is poorly understood. Here, we report...
Unveiling a proton-coupled electron-transfer mechanistic library of nitrate to ammonia via ultramicroelectrode-hyphenated mass spectrometry
For valuable ammonia synthesis and green nitrogen recycling, electrocatalytic nitrate reduction reaction (NO 3 RR) presents a sustainable alternative to the con...
Imputing unjustified bulk density values to soils with biochar addition biases soil carbon sequestration estimates
Network structure shapes consensus dynamics through individual decisions
How do shared narratives emerge in decentralized online networks? Prior research using simplified group coordination tasks (e.g., face-naming) shows network structure shapes group consensus, but the u...
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution
Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae...
Correction to Supporting Information for Li et al., p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage
Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis
Metabolic dysfunction–associated steatotic liver disease (MASLD) is characterized by liver steatosis with cardiometabolic risk factors like dyslipidemia. Patients may progress from steatosis alone to...
Correction for He et al., GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
USP25 inhibition ameliorates Parkinson’s disease by restoring mitophagy
Parkinson’s disease (PD) is a progressive neurodegenerative disease that casts a significant shadow over global health and the identification of therapeutic targets for PD will empower more effective...
Multimetallic synergies in tandem plasmonic photocatalysis
Gender stereotypes across nations relate to the social position of women and men: Evidence from cross-cultural public opinion polls
Gender stereotypes, defined as widely shared beliefs about the typical attributes of women and men, have far-reaching consequences for both stereotyped groups. This preregistered research examined cro...
Reframing the axon initial segment: Giant ankyrin-G as a modulator of excitability and plasticity in neurodevelopment
Optimizing mRNA delivery with targeted elastin-like polypeptide–based LENN formulations: Insights into the endocytosis mechanism
Gene delivery has emerged as a groundbreaking technique for altering gene expression, offering new possibilities in treating a vast array of diseases. We report a layer-by-layer elastin-like polypepti...
Museum collections provide a temporal record of past genetic variation
Unintended consequences of well-intended interventions
Can paleontologists pinpoint the dawn of the dinosaurs?
Charting a course for the National Academies and the nation we serve
Hydroxo-bridged active site of flavodiiron NO reductase revealed by NRVS and DFT
The use of oxygen and nitrate as terminal electron acceptors provides organisms with a huge amount of available energy but necessitates methods to detoxify reactive intermediates. The mechanisms of NO...
<i>Chlamydomonas</i> chloroplast genes tolerate compression of the genetic code to just 51 codons
Genome scale engineering has enabled codon compression of the universal genetic code to eliminate seven codons in Escherichia coli...
Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis
Systemic light chain amyloidosis (AL) is characterized by amyloid fibril deposition in multiple organs, often severely affecting cardiac function. In this study, we extracted amyloid fibrils directly...
Immature <i>Caenorhabditis elegans</i> motor neurons control early embryo behavior via both synaptic and nonsynaptic GABA release
Prenatal brain activity has long lasting effects on subsequent neurodevelopment. It is unclear if early brain activity is dominated by cell intrinsic, synaptic, or nonsynaptic mechanisms. We address t...
Reconstructing the early spatial spread of pandemic respiratory viruses in the United States
Understanding the geographic spread of emerging respiratory viruses is critical for pandemic preparedness, yet the early spatiotemporal dynamics of the 2009 H1N1 pandemic influenza and severe acute re...
Prior novelty invigorates future mesolimbic target detection
The ability to adapt to a dynamic world relies on detecting, learning, and responding to environmental changes. The detection of novelty serves as a critical indicator of such changes, priming mechani...
Constitutively high levels of endogenous soluble ST2 inhibit food allergic responses in mice
IL-33-induced signals via membrane-bound ST2 (ST2L) are critical for allergies. However, the physiological role of endogenous soluble ST2 (sST2) remains elusive. Here, we generated sST2-deficient mice...