Proceedings of the National Academy of Sciences
Articles in this Issue
A minimal vertex model explains how the amnioserosa avoids fluidization during <i>Drosophila</i> dorsal closure
Dorsal closure is a process that occurs during embryogenesis of Drosophila melanogaster . During dorsal closure, the amnioserosa (AS), a one-cell thick epitheli...
Unveiling hidden reaction kinetics of carbon dioxide in supercritical aqueous solutions
Dissolution of CO 2 in water followed by the subsequent hydrolysis reactions is of great importance to the global carbon cycle, and carbon capture and storage....
Binding mode–guided development of high-performance antibodies targeting site-specific posttranslational modifications
Posttranslational modifications (PTMs) of proteins play critical roles in regulating many cellular events. Antibodies targeting site-specific PTMs are essential tools for detecting and enriching PTMs...
ANAC044 orchestrates mitochondrial stress signaling to trigger iron-induced stem cell death in root meristems
While iron (Fe) is essential for life and plays important roles for almost all growth related processes, it can trigger cell death in both animals and plants. However, the underlying mechanisms for Fe...
VCP controls KCC2 degradation through FAF1 recruitment and accelerates emergence from anesthesia
Ubiquitin-proteasomal degradation of K + /Cl − cotransporter 2 (KCC2) in the ventral posteromedial nucleus (VPM) has bee...
Parallel vector memories or single memory updating?
Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM
The homo-dodecameric ring-shaped trp RNA binding attenuation protein (TRAP) from Alkalihalobacillus halodurans (Aha) bin...
Collaborative management partnerships strongly decreased deforestation in the most at-risk protected areas in Africa since 2000
Collaborative management partnerships (CMPs) between state wildlife authorities and nonprofit conservation organizations to manage protected areas (PAs) have been used increasingly across Sub-Saharan...
Complex tissue regeneration in <i>Lophuromys</i> reveals a phylogenetic signal for enhanced regenerative ability in deomyine rodents
Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed rep...
PsDMAP1/PsTIP60-regulated H4K16ac is required for ROS-dependent virulence adaptation of <i>Phytophthora sojae</i> on host plants
Host plants and various fungicides inhibit plant pathogens by inducing the release of excessive reactive oxygen species (ROS) and causing DNA damage, either directly or indirectly leading to cell deat...
Metabolic enhancement contributed by horizontal gene transfer is essential for dietary specialization in leaf beetles
Horizontal gene transfer (HGT) from bacteria to insects is widely reported and often associated with the adaptation and diversification of insects. However, compelling evidence demonstrating how HGT-c...
Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and the primary cause of mortality in patients with neurofibromatosis type 1 (NF1). These malignancies develop within preexist...
Population encoding of observed and actual somatosensations in the human posterior parietal cortex
Cognition relies on transforming sensory inputs into a generalizable understanding of the world. Mirror neurons have been proposed to underlie this process, mapping visual representations of others’ a...
Dissecting the cellular architecture and genetic circuitry of the soybean seed
Seeds are complex structures composed of three regions, embryo, endosperm, and seed coat, with each further divided into subregions that consist of tissues, cell layers, and cell types. Although the s...
Climate change could amplify weak synchrony in large marine ecosystems
Climate change is increasing the frequency of large-scale, extreme environmental events and flattening environmental gradients. Whether such changes will cause spatially synchronous, large-scale popul...
Computational-aided rational mutation design of pertuzumab to overcome active HER2 mutation S310F through antibody–drug conjugates
Recurrent missense mutations in the human epidermal growth factor receptor 2 (HER2) have been identified across various human cancers. Among these mutations, the active S310F mutation in the HER2 extr...
<i>Salmonella</i> infection accelerates postnatal maturation of the intestinal epithelium
Postnatal establishment of enteric metabolic, host–microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infe...
A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release
Neurotransmitter release is triggered in microseconds by Ca 2+ -binding to the Synaptotagmin-1 C 2 -domains and by SNARE...
Oncogenic IDH1 <sup>mut</sup> drives robust loss of histone acetylation and increases chromatin heterogeneity
Malignant gliomas are heterogeneous tumors, mostly incurable, arising in the central nervous system (CNS) driven by genetic, epigenetic, and metabolic aberrations. Mutations in isocitrate dehydrogenas...
US Corn Belt enhances regional precipitation recycling
Precipitation recycling, where evapotranspiration (ET) from the land surface contributes to precipitation within the same region, is a critical component of the water cycle. This process is especially...
Deciphering the artificial evolution of domesticated plants within dynamic habitats
Development of precision medicine approaches to advance clinical trials for autism and social behavior: A research imperative
The return of stagnant slab recorded by intraplate volcanism
Subducted plates often stagnate in the mantle transition zone (MTZ), and the fate of the stagnant slabs is still debatable. They may sink into the lower mantle, or remain partially trapped in the MTZ,...
Metastable state preceding shear zone instability: Implications for earthquake-accelerated landslides and dynamic triggering
Understanding the dynamic response of granular shear zones under cyclic loading is fundamental to elucidating the mechanisms triggering earthquake-induced landslides, with implications for broader fie...
How and why funders support engaged research
Research that better aligns policy, practice, and research communities is gaining momentum around the world. This includes engaged research strategies that bring partners, and their diverse perspectiv...