Proceedings of the National Academy of Sciences
Articles in this Issue
Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells
Heterogeneous roles of complement C3 have been implicated in tumor metastasis and are highly context dependent. However, the underlying mechanisms linking C3 to tumor metastasis remain elusive in rena...
Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6
Lysophosphatidic acid (LPA) exerts its physiological roles through the endothelialdifferentiation gene (EDG) family LPA receptors (LPAR1-3) or the non-EDG family LPA receptors (LPAR4-6). LPAR6 plays c...
Microfluidic purification of genomic DNA
We describe a microfluidic device to extract DNA from a cell lysate, without the need for centrifuges, magnetic beads, or gels. Instead, separation is driven by transverse migration of DNA, which occu...
Metabolic activity controls the emergence of coherent flows in microbial suspensions
Photosynthetic microbes have evolved and successfully adapted to the ever-changing environmental conditions in complex microhabitats throughout almost all ecosystems on Earth. In the absence of light,...
The functional role of oscillatory dynamics in neocortical circuits: A computational perspective
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are explo...
The LIM-domain-only protein LMO2 and its binding partner LDB1 are differentially required for class switch recombination
The LIM-domain-only protein LMO2 interacts with LDB1 in context-dependent multiprotein complexes and plays key roles in erythropoiesis and T cell leukemogenesis, but whether they have any roles in B c...
Coding relationship links RNA G-quadruplexes and protein RGG motifs in RNA-binding protein autoregulation
RNA G-quadruplexes (rG4s), the four-stranded structures formed by guanine-rich RNA sequences, are recognized by regions in RNA-binding proteins (RBPs) that are enriched in arginine-glycine repeats (RG...
Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning
Efficient planning is a distinctive hallmark of intelligence in humans, who routinely make rapid inferences over complex world contexts. However, studies investigating how humans accomplish this tend...
Governing in the face of a global crisis: When do voters punish and reward incumbent governments?
The recent COVID-19 pandemic offers a rare opportunity to understand how citizens attribute responsibility for governments’ responses to unanticipated negative—and in this case, systemic—exogenous sho...
Enhancing drug solubility through competitive adsorption on silica nanosurfaces with ultrahigh silanol densities
We develop a technology based on competitive adsorption between drug molecules and water, specifically designed to address the critical issue of poor drug solubility. By specially engineering silica n...
A carnitine transporter at the blood–brain barrier modulates sleep via glial lipid metabolism in <i>Drosophila</i>
To regulate brain function, peripheral compounds must traverse the blood–brain barrier (BBB), an interface between the brain and the circulatory system. To determine whether specific transport mechani...
Behavioral nudges prevent loan delinquencies at scale: A 13-million-person field experiment
Americans collectively hold over $1.6 trillion in student loan debt, and over the last decade millions of borrowers have defaulted on loans, with serious consequences for their financial health. In a...
Spreading dynamics of information on online social networks
Social media is profoundly changing our society with its unprecedented spreading power. Due to the complexity of human behaviors and the diversity of massive messages, the information-spreading dynami...
Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module
Light serves as an energy source for cell division and expansion during fruit development. Cell expansion significantly influences fruit size and is closely linked to endoreduplication, a unique cell...
The perceptual primacy of feeling: Affectless visual machines explain a majority of variance in human visually evoked affect
Looking at the world often involves not just seeing things, but feeling things. Modern feedforward machine vision systems that learn to perceive the world in the absence of active physiology, delibera...
Iron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter
Chemical communication between marine bacteria and their algal hosts drives population dynamics and ultimately determines the fate of major biogeochemical cycles in the ocean. To gain deeper insights...
Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation common...
Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin
Many proteins form paralogous multimers—molecular complexes in which evolutionarily related proteins are arranged into specific quaternary structures. Little is known about the mechanisms by which the...
ANKRD11 binding to cohesin suggests a connection between KBG syndrome and Cornelia de Lange syndrome
Ankyrin Repeat Domain-containing Protein 11 ( ANKRD11 ) is a causative gene for KBG syndrome, a significant risk factor for Cornelia de Lange syndrome (CdLS), a...
Epstein–Barr virus BALF0/1 subverts the Caveolin and ERAD pathways to target B cell receptor complexes for degradation
Epstein–Barr virus (EBV) establishes persistent infection, causes infectious mononucleosis, is a major trigger for multiple sclerosis and contributes to multiple cancers. Yet, knowledge remains incomp...
Structural insights into glucose-6-phosphate recognition and hydrolysis by human G6PC1
The glucose-6-phosphatase (G6Pase) is an integral membrane protein that catalyzes the hydrolysis of glucose-6-phosphate (G6P) in the endoplasmic reticulum lumen and plays a vital role in glucose homeo...
Band asymmetry–driven nonreciprocal electronic transport in a helimagnetic semimetal α-EuP <sub>3</sub>
Chiral magnetic textures give rise to unconventional magnetotransport phenomena such as the topological Hall effect and nonreciprocal electronic transport. While the correspondence between topology or...
BCL6 coordinates muscle mass homeostasis with nutritional states
Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional sta...
Preventing inappropriate signals pre- and post-ligand perception by a toggle switch mechanism of ERECTA
Dynamic control of signaling events requires swift regulation of receptors at an active state. By focusing on the Arabidopsis ERECTA (ER) receptor kinase, which perceives peptide ligands to control mu...
Layer-specific control of inhibition by NDNF interneurons
Neuronal processing of external sensory input is shaped by internally generated top–down information. In the neocortex, top–down projections primarily target layer 1, which contains NDNF (neuron-deriv...