Proceedings of the National Academy of Sciences
Articles in this Issue
Lost opportunities: How gendered arrangements harm men
Traditional gendered arrangements—norms, roles, prejudices, and hierarchies—shape every human life. Associated harms are primarily framed as women’s issues due to more severe consequences women face....
Correction for Luo et al., Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration
Correction for Wu et al., NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus
Correction for He et al., Structural insights into the assembly and energy transfer of haptophyte photosystem I–light-harvesting supercomplex
Correction for Humbert et al., Functional SARS-CoV-2 cross-reactive CD4 <sup>+</sup> T cells established in early childhood decline with age
Cryo-ET suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules
The functional architecture of the long-lived neuronal microtubule (MT) cytoskeleton is maintained by various MT-associated proteins (MAPs), most of which are known to bind to the MT outer surface. Ho...
Art promotes exploration of negative content
Experiencing negative content through art has a unique power to transform our perceptions and foster engagement. While this idea has been widely discussed, empirical evidence is scarce, since experime...
Transferrin promotes fatty acid oxidation and liver tumor growth through PHD2-mediated PPARα hydroxylation in an iron-dependent manner
Tumor cells reshape iron and lipid metabolism for their rapid proliferation. However, how tumor cells coordinate the interplay between tumor cell–specific iron homeostasis and lipid metabolism reprogr...
Unconventional magnetic oscillations in a kagome Mott insulator
In metals, electrons in a magnetic field undergo cyclotron motion, leading to oscillations in physical properties called quantum oscillations. This phenomenon has never been seen in a robust insulator...
A pentatomomorpha-specific salivary protein activates plant immunity and is critical for insect feeding
The stinkbug Riptortus pedestris , notorious for inducing soybean staygreen-like syndrome, employs a range of salivary proteins to manipulate the host plant for...
Extremal structures with embedded prefailure indicators
Preemptive identification of potential failure under loading of engineering structures is a critical challenge. Our study presents an innovative approach to design built-in prefailure indicators withi...
SIV monoclonal antibody administration spanning treatment interruption in macaques delays viral rebound and selects escape variants
HIV-1 envelope broadly neutralizing antibodies represent a promising component of HIV-1 cure strategies. To evaluate the therapeutic efficacy of combination monoclonal antibodies (mAbs) in a rigorous...
Plastic responses to past environments shape adaptation to novel selection pressures
Phenotypic plasticity may pave the way for rapid adaptation to newly encountered environments. Although it is often contested, there is growing evidence that initial plastic responses of ancestral pop...
Optimal strategies for correcting merotelic chromosome attachments in anaphase
Accurate chromosome segregation in mitosis depends on proper connections of sister chromatids, through microtubules, to the opposite poles of the early mitotic spindle. Transiently, many inaccurate co...
Errors are robustly tamed in cumulative knowledge processes
As knowledge accumulates in science and society in a distributed fashion, erroneous derivations can be introduced into the corpus of knowledge. Such derivations can compromise the validity of any unit...
Design of a light and Ca <sup>2+</sup> switchable organic–peptide hybrid
The design of organic–peptide hybrids has the potential to combine our vast knowledge of protein design with small molecule engineering to create hybrid structures with complex functions. Here, we des...
Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug
Aging is a complex process that affects multiple organs, and the discovery of a pharmacological approach to ameliorate aging is considered the Holy Grail of medicine. Here, we performed an N-ethyl-N-n...
Natural variations in <i>TT8</i> and its neighboring <i>STK</i> confer yellow seed with elevated oil content in <i>Brassica juncea</i>
Seed color is a critical quality trait in numerous plant species. In oilseed Brassica crops, including rapeseed and mustard, yellow seeds are distinguished by t...
Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthesized through complex, mu...
Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model
The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the CA3 region. In turn, attractor dynamics in CA3 p...
CBX2 suppresses interferon signaling to diminish tumor immunogenicity via a noncanonical corepressor complex
Chromobox 2 (CBX2), a crucial component of the polycomb repressive complex (PRC), has been implicated in the development of various human cancers. However, its role in the regulation of tumor immunoge...
Uterine organoids reveal insights into epithelial specification and plasticity in development and disease
Understanding how epithelial cells in the female reproductive tract (FRT) differentiate is crucial for reproductive health, yet the underlying mechanisms remain poorly defined. At birth, FRT epitheliu...
Activation of the conserved Hippo kinases by inflammasome-triggered proteolytic cleavage controls programmed cell death in macrophages
The mammalian Hippo kinases, MST1 and MST2, regulate organ development and suppress tumor formation by balancing cell proliferation and death. In macrophages, inflammasomes detect molecular patterns f...