Proceedings of the National Academy of Sciences
Articles in this Issue
A global estimate of multiecosystem photosynthesis losses under microplastic pollution
Understanding how ecosystems respond to ubiquitous microplastic (MP) pollution is crucial for ensuring global food security. Here, we conduct a multiecosystem meta-analysis of 3,286 data points and re...
How nidoviruses evolved the largest known RNA genomes
Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), which is linked to Epstein–Barr virus (EBV) infection, preceding the disease. The molecular mechani...
Populations of large-diameter trees are increasing across the United States
Large-diameter trees provide vital ecological functions in forested ecosystems. Old, large-diameter trees may also be vulnerable to climate-driven mortality events, but past work on large tree populat...
Insulation between adjacent TADs is controlled by the width of their boundaries through distinct mechanisms
Topologically associating domains (TADs) are sub-Megabase regions in vertebrate genomes with enriched intradomain interactions that restrict enhancer–promoter contacts across their boundaries. However...
Quantifying compositional variability in microbial communities with FAVA
Microbial communities vary across space, time, and individual hosts, generating a need for statistical methods capable of quantifying variability across multiple microbiome samples at once. To underst...
Amplification-free, OR-gated CRISPR-Cascade reaction for pathogen detection in blood samples
Rapid and accurate detection of DNA from disease-causing pathogens is essential for controlling the spread of infections and administering timely treatments. While traditional molecular diagnostics te...
The <i>Arabidopsis</i> demethylase REF6 physically interacts with phyB to promote hypocotyl elongation under red light
The plant photoreceptor phytochrome B (phyB) mediates the responses of plants to red (R) light. Trimethylation of histone H3 at Lys27 (H3K27me3) plays a crucial role in governing gene expression and c...
eDNA confirms lower trophic interactions help to modulate population outbreaks of the notorious crown-of-thorns sea star
Variability in predator–prey interactions can modulate population dynamics with impacts scalable to entire ecosystems. As notorious corallivores, crown-of-thorns sea stars (CoTS; A...
G-quadruplexes and their unexpected ability to fold proteins
DR5 is a restriction factor for human herpesviruses
Restriction factors are dominant proteins that target different essential steps of the viral life cycle; thus, these proteins provide an early line of defense against viruses. Here, we found that the...
Behold the scale of global zoogeomorphic activity
Identifying the interactions conferring functional mechanical rigidity on RNase-resistant RNA from Zika virus
Some viruses counter host-cell efforts to digest invading viral RNA by using special structures resistant to host RNases, known as exoribonuclease-resistant RNAs (xrRNAs). xrRNAs typically form an unu...
Negative trend in total solar irradiance over the satellite era
Linear trends in total solar irradiance (TSI) between different reconstructions of the satellite era, defined as 1978 to 2023, disagree by up to 0.17 W/m 2 per...
Physical proximity drives gay discrimination in the gig economy
Despite legal protections, discrimination based on sexual orientation remains difficult to detect and measure in labor markets. We present evidence from a field experiment ( N...
Cell extrusion drives neural crest cell delamination
Neural crest cells (NCC) comprise a heterogeneous population of cells with variable potency that contribute to nearly every tissue and organ throughout the body. Considered unique to vertebrates, NCC...
Earth greening and climate change reshaping the patterns of terrestrial water sinks and sources
While vegetation brings positive benefits for climate mitigation and adaptation, the impact of ongoing global greening remains controversial due to its uncertain effects on hydrological cycle. Here, w...
Sequential evolution of resistance by western corn rootworm to multiple <i>Bacillus thuringiensis</i> traits in transgenic maize
Transgenic crops that produce insecticidal toxins derived from the bacterium Bacillus thuringiensis (Bt) are grown worldwide to manage insect pests. Western cor...
Competition for shared resources increases dependence on initial population size during coalescence of gut microbial communities
The long-term success of introduced populations depends on both their initial size and ability to compete against existing residents, but it remains unclear how these factors collectively shape coloni...
Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain
Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interact...
Eukaryotic phytoplankton drive a decrease in primary production in response to elevated CO <sub>2</sub> in the tropical and subtropical oceans
Ocean acidification caused by increasing anthropogenic CO 2 is expected to impact marine phytoplankton productivity, yet the extent and even direction of these...
Cell type and region-specific transcriptional changes in the endometrium of women with RIF identify potential treatment targets
Recurrent implantation failure (RIF) is a devastating condition that leaves many undergoing fertility treatment childless. The human endometrium is receptive to a blastocyst for a brief period, the wi...
Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors
In early postnatal and young adult bone marrow, Leptin receptor–expressing (LepR + ) stromal cells and endothelial cells synthesize factors required for hematop...
Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel whose dysfunction leads to intracellular accumulation of chloride ions, dehydration of cell surfaces, and subsequen...