Proceedings of the National Academy of Sciences
Articles in this Issue
Migration shapes senescence in a long-lived bird
Each year, billions of animals migrate across the globe on diverse spatial and temporal scales. Migration behavior thus plays a fundamental role in the life cycle and Darwinian fitness of many organis...
9,000-year-old barley consumption in the foothills of central Asia
Scholars are increasingly favoring models for the origins of agriculture that involve a protracted process of increasing interdependence within a series of mutualistic relationships between humans and...
Atomic armor for thermal stability in nanoporous structures
Nanoporous structures play a critical role in a wide range of applications, including catalysis, thermoelectrics, energy storage, gas adsorption, and thermal insulation. However, their thermal instabi...
Joint models reveal human subcortical underpinnings of choice and learning behavior
Decision making and learning processes together enable adaptive strategic behavior. Animal studies demonstrated the importance of subcortical regions in these cognitive processes, but the human subcor...
A mosquito-inspired theoretical framework for acoustic signal detection
Distortion products are tones produced through nonlinear effects of a system simultaneously detecting two or more frequencies. These combination tones are ubiquitous to vertebrate auditory systems and...
Action at a distance: The remarkable coupling of CO <sub>2</sub> uptake to electron transfer in specialized cyanobacterial NDH-1 complexes
Cyanobacteria achieve highly efficient photosynthesis using a CO 2 -concentrating mechanism relying on specialized Type I (NDH-1) complexes. Among these, NDH-1...
Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation
Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tum...
Origami frustration and its influence on energy landscapes of origami assemblies
Harnessing instabilities of multicomponent multistable structural assemblies can potentially lead to scalable and reversible functionalities, which can be enhanced by exploring frustration. For instan...
Integrated Ising model with global inhibition for decision-making
Humans and other organisms make decisions choosing between different options, with the aim of maximizing the reward and minimizing the cost. The main theoretical framework for modeling the decision-ma...
Ultracold cryogenic TEM with liquid helium and high stability
Cryogenic transmission electron microscopy has revolutionized structural biology and materials science. To image below liquid nitrogen temperatures, various liquid helium stages have been constructed...
PD-1 expression identifies proliferating malignant CLL B cells and is a potential biomarker of response to BTK inhibitor therapy
Chronic lymphocytic leukemia (CLL) remains incurable despite treatment advances, and a major challenge is that biomarkers that predict response and resistance to current therapies are lacking. We repo...
From relaxation to buckling: A continuum elastic framework connecting surface instabilities of highly compressed lipid thin films
Self-assembled thin films respond to external loads via surface instabilities that are critical to their functionality in both biology and technology. Lipid monolayers at the air–liquid interface are...
Long-term history of continental weathering and particle transport to the sea
Here, we explore the long-term history of chemical weathering and particle transport from the continents to the oceans by leveraging the histories of Zr/Al, Rb/Al, and Na/Al in marine sediments over t...
Testis expressed 50 is essential for maintaining sperm acrosome integrity during epididymal transit
In mammals, sperm formation is completed in the seminiferous tubules within the testis, and sperm maturation occurs during the epididymal transit of the spermatozoa. Sperm morphology drastically chang...
Ecology and sexual conflict drive the macroevolutionary dynamics of female-limited color polymorphisms in damselflies
Sexual conflict over mating has been documented in many species, both in the field and in experimental studies. In pond damselflies (family Coenagrionidae), sexual conflict maintains female-limited co...
Correction for Pang et al., Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission
Founders predict trait evolution and population performance after evolutionary rescue in the red flour beetle
Evolutionary rescue helps populations survive environmental change, but the phenotypic and demographic factors associated with rescue dynamics and its long-term effects remain unclear. We experimental...