Proceedings of the National Academy of Sciences
Articles in this Issue
Aducanumab binding to Aβ <sub>1-42</sub> fibrils alters dynamics of the N-terminal tail while preserving the fibril core
Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody...
Evolution of viral genomes and their clouds of sequence
SR-LLM: An incremental symbolic regression framework driven by LLM-based retrieval-augmented generation
Symbolic regression (SR) has regained research prominence as deep learning advancements accelerate the search for analytical models from observational data. However, the vast search space often hinder...
Lipid-packing defects are sufficient to modulate membrane insertion and the bound state of α-synuclein
α-Synuclein is an intrinsically disordered neuronal protein that forms an amphipathic helix when it peripherally binds to lipid membranes. This membrane interaction is integral to the protein’s functi...
A neuromorphic robotic electronic skin with active pain and injury perception
Humanoid robots with advanced sensory capabilities are increasingly demanded for empathetic, close-contact interactions with humans. Electronic skin (E-skin) is a key enabling technology for such tact...
Synaptic integration and competition in the substantia nigra pars reticulata—An experimental and in silico analysis
The substantia nigra pars reticulata (SNr) is a primary output for basal ganglia signaling. It plays an important role in the control of movement, integrating inputs from upstream structures in the ba...
Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury
Some patients with moderate to severe traumatic brain injury (TBI) make a full recovery, while others remain severely disabled. Accurate prognostication is important, because withdrawal of life-sustai...
Symmetries and selection rules in photoelectron chiral dichroism
Photoelectron circular dichroism (PECD) is a method whereby randomly oriented chiral molecules are irradiated by circularly polarized light (CPL), photoionizing electrons, which are measured in a mome...
Global vaccination coverage and disease incidence in cattle, pigs, and poultry
Vaccination against livestock diseases is an effective method to prevent and control the spread of pathogens and reduce antimicrobial consumption and livestock production losses. Systematic data on gl...
Multiplex mapping of protein–protein interaction interfaces
We describe peptide mapping through Split Antibiotic Resistance Complementation (SpARC-map), a method to identify the probable interface between two interacting proteins. Our method is based on in viv...
Intensified tropical cyclone activity in East Asia during the Maunder (solar) Minimum
This study reports a tropical cyclone (TC) series reconstructed from documentary records that have been digitized in the REACHES database for the period of 1368–1911. The series has been validated thr...
Road expansion risk predicts future hotspots of tropical deforestation
Roads act as conduits for human incursions and hence underlie many of humanity’s impacts on nature, including deforestation, wildfires, and natural-resource overexploitation. Unfortunately, existing r...
Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A
The interaction between the immune system and the somatosensory system plays a fundamental role in the regulation of diverse biological processes. Chronic itch is a common yet hard-to-treat symptom of...
A conserved hub protein required for peptidoglycan remodeling and cell division in <i>Acinetobacter baumannii</i>
Gram-negative bacteria build a multilayered cell envelope in which the peptidoglycan layer is sandwiched between an inner membrane of glycerophospholipids and an asymmetric outer membrane composed of...
How lipids speak to nerves
The neural substrates of behavioral evolution: Divergent behaviors from conserved neurons
Getting gene expression “just right”
Breathing life into the boring billion: Direct constraints from 1.4 Ga fluid inclusions reveal a fair climate and oxygenated atmosphere
The Mesoproterozoic eon [1.8 to 0.8 billion years ago (Ga)] is a crucial but enigmatic period in Earth’s history. Many facets of this interval remain unresolved, especially how atmospheric evolution i...
Molecular mechanism of substrate transport by human peroxisomal ABCD3
ATP-binding cassette transporters of the D subfamily (ABCD1-3) mediate the export of CoA thioesters of fatty acids from the cytosol into peroxisomes for further oxidation. ABCD3 facilitates the transp...
Sensing the shape of a surface by tightly surface-bound filaments
Understanding the mechanisms that dictate the localization of cytoskeletal filaments is crucial for elucidating cell shape regulation in prokaryotes. The actin homolog MreB plays a pivotal role in mai...
ATM interaction with GRP94 modulates oncogenic receptor expression and signaling and microglial activation
Ataxia-telangiectasia (A-T), caused by biallelic mutations in the ATM gene, leads to multiple disease phenotypes, including cerebellar neurodegeneration, radiosensitivity, cancer predisposition, immun...