Blood
Articles in this Issue
Outcomes of eltrombopag combined with immunosuppressive therapy in adults with severe aplastic anemia: A large, propensity-matched retrospective analysis
Abstract Background: The addition of eltrombopag (EPAG) to standard immunosuppressive therapy (IST) has improved hematologic response rates i...
Venetoclax or pirtobrutinib in relapsed/refractory Waldenström macroglobulinemia: Clinical and molecular predictors and sequencing implications
Abstract Introduction: Venetoclax and pirtobrutinib are two novel targeted agents used for the treatment of relapsed or refractory Waldenströ...
Trends in mortality and comorbidity of multiple myeloma among u.S. adults with stroke: A CDC wonder-based analysis, 1999–2023
Abstract Background : Multiple Myeloma, a malignancy of the plasma cells remains one of the reasons for widespread morbidity and mortality....
Explainable AI-based prediction of chronic kidney disease as a long-term outcome of sickle cell disease in a large, multi-site observational data cohort
Abstract Introduction Sickle cell disease (SCD) is a hereditary hemolytic anemia due to abnormal polymerization of intra-erythrocytic hemogl...
Disparities and reversal of declines: A 22-year analysis of mortality trends in patients with concurrent anemia and heart failure in the United States (1999–2020)
Abstract Introduction Anemia is a common comorbidity among patients with heart failure (HF), associated with worse funct...
Outcomes of CAR T-cell therapies after prior treatment with fixed-duration mosunetuzumab in patients with relapsed/refractory B-cell non-Hodgkin lymphoma
Abstract Background: Mosunetuzumab (Mosun) is a CD20xCD3 bispecific antibody (BsAb) evaluated in patients (pts) with B-cell non-Hodgkin lymp...
Etavopivat in adolescents with sickle cell disease: Emerging safety and efficacy findings from the first cohort of the ongoing Phase 1/2 hibiscus kids study
Abstract Background: Etavopivat is a selective, orally bioavailable, small-molecule activator of the pyruvate kinase red blood cell (RBC) is...
Machine learning accurately predicts mortality in adult NPM1-mutant Acute Myeloid Leukemia using baseline clinical and genomic features
Abstract Introduction Nucleophosmin1-mutated (NPM1m) acute myeloid leukemia (AML) accounts for ~30% of adult AML and is generally considered...
Using electronic consultations to identify hematology education needs in primary care
Abstract BackgroundTopics covered in primary care Continuing Professional Development (CPD) activities often do not reflect the real-world l...
A dangerous convergence: Long-term mortality trends in aplastic anemia and sepsis (1999-2023)
Abstract Background: Aplastic anemia (AA), a rare hematologic disorder characterized by pancytopenia and bone marrow failure, poses a high r...
Sarcopenia and body composition predict survival and reveal immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma
Abstract Introduction: Chimeric Antigen Receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed/refra...
Unravelling the epigenetic drivers of chip – MDS/CMML – AML progression through novel methylation-sensitive regulatory elements
Abstract Epigenetic reprogramming, particularly aberrant DNA methylation, drives many myeloid malignancies. While some patients have identif...
Rhoifolin, an inhibitor targeting the ALDH2-PKC delta axis, eradicates MRD in chronic myeloid leukemia by eliminating leukemia stem cells
Abstract Background: Chronic myeloid leukemia (CML) patients frequently develop minimal residual disease (MRD) following tyrosine kinase inh...
Real-world efficacy outcomes of epcoritamab and glofitamab in Relapsed/Refractory aggressive B-cell lymphoma: A single-center cohort emphasizing trial-ineligible populations
Abstract Introduction The CD20xCD3 bispecific antibodies (BsAbs), epcoritamab (Epco) and glofitamab (Glofi), have emerged as effective thera...
Long-read single-cell isoform sequencing for cell type-specific detection of genomic rearrangement-dependent and -independent fusion transcripts
Abstract Background: Fusion transcripts are formed by combining exons from two different genes, often due to structural rearrangements such...
Why are mice lymphocytic and primates granulocytic? an evo-devo approach to granulopoiesis
Abstract Neutrophils play a critical role as first-line, non-specific responders in the innate immune system. They are characterized by thei...
Cannabinoid exposure in utero exacerbates hyperalgesia in offspring of sickle mice
Abstract Approximately 5% of pregnant women in the United States and 20% of pregnant women aged 18-24 years in California reported using can...
Outcomes of omidubicel-expanded umbilical cord blood transplantation in patients with severe aplastic anemia
Abstract Introduction Severe Aplastic Anemia (SAA) is a life-threatening disorder characterized by bone marrow failure, pancytopenia, infect...
Pediatric-inspired regimens for ALL are not associated with improved overall survival in US hispanic adult patients
Abstract Background: Adult ALL outcomes have significantly improved with the adoption of pediatric inspired regiments (PIR). However, these...
CSF-1R+ macrophages orchestrate human skin chronic graft-versus-host disease
Abstract Skin is the most frequently involved organ in chronic graft-versus-host disease (cGVHD) and presents as superficial lichenoid lesio...
A prospective, multicenter study on stem cell mobilization using EAP regimen as first-line mobilization in patients with multiple myeloma and lymphoma
Abstract Background: The optimal stem cell mobilization strategy in multiple myeloma (MM) and lymphoma remains debatable. We evaluated the e...
Targeting PRMT7 enhances the anti-AML immunity by regulating MHC-I
Abstract Protein arginine methylation regulates several cellular functions, including RNA splicing, translation and DNA damage repair. Prote...
The development of FT839: An off-the-shelf CD19xCD38 dual-CAR T cell for the treatment of multiple myeloma
Abstract Following autologous chimeric antigen receptor (CAR) T-cell therapy, approximately 50% of multiple myeloma (MM) patients relapse wi...
Outcome of bridging therapy in chimeric antigen receptor T cell treatment for Relapsed/Refractory B-cell non-Hodgkin lymphoma: A retrospective study.
Abstract Background: The CD19-targeted chimeric antigen receptor T (CAR-T) cell therapy has achieved significant efficacy in the treatment o...
Characterization of hemophagocytic lymphohistiocytosis (HLH) in an urban population: Demographics, associated risk factors, and identifying areas for improvement
Abstract Introduction Hemophagocytic Lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterized by exces...