Blood
Articles in this Issue
Outcomes of haploidentical transplantation with umbilical cord blood co-infusion in aplastic anemia: Clinical and single-cell insights
Abstract Aplastic anemia (AA) is a life-threatening disorder characterized by pancytopenia and bone marrow failure. Hematopoietic stem cell...
Monocyte-T cells crosstalk orchestrates early graft-versus-leukemia immunity in Acute Myeloid Leukemia patients after allogeneic transplantation
Abstract Background Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Hematopoietic stem cell transplantation (HSCT)...
Discovery of JAK2V617F mutant specific allosteric inhibitors for the treatment of myeloproliferative neoplasms
Abstract The V617F mutation in Janus Kinase 2 (JAK2V617F) is a recurrent driver of myeloproliferative neoplasms (MPNs), including myelofibro...
Dissecting India's molecular hematology landscape: A 1000-patient genomic study identifies geographic clusters, signature enrichments, and young-onset AML
Abstract Genomic data on hematologic malignancies from low- and middle-income countries (LMICs) remain sparse. India, with its diverse ances...
Late recurrence of transfusion dependent thalassemia 30 years after transplantation
Abstract Here we report 5 cases of patients transplanted in the eighties/early nineties who experienced an unexpected, unheralded, and unexp...
Trends and predictors of inpatient mortality in patients with aplastic anemia: A 7-year national inpatient sample analysis
Abstract Background:Aplastic anemia (AA) is a rare but serious hematologic disorder that results from immune-mediated destruction of hematop...
Real-world treatment patterns, outcomes, and unmet needs in patients with ph+ ALL receiving tyrosine kinase inhibitors in the United States: Emerging trends and the role of asciminib-based combinations
Abstract Background: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is the predominant genetic ALL subtype in adult...
Association between obesity and venous thromboembolism in hospitalized patients with multiple myeloma - perspective from national inpatient sample (NIS) database
Abstract Background: Patients with multiple myeloma (MM) have a high risk of venous thromboembolism (VTE) due to disease and treatment relat...
Molecular and clinical characteristics of NUP98 rearrangements and their therapeutic responses in 6,000 patients with hematologic malignancies
Abstract Background: Translocations involving nucleoporin 98 (NUP98) and over 30 fusion partner genes are well-characterized drivers of hemat...
Biomarkers for venous thromboembolism in children with central venous catheters
Abstract Background The incidence of venous thromboembolism (VTE) in children has been increasing by about 10% per year...
A subset of patients achieve prolonged remission beyond 3–5 years with FHVH33-CD8BBZ BCMA CAR T-cells for RRMM
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA) has transformed the treatment...
Disruption of intestinal homeostasis reflected by DAO and microbiota alterations in gvhd post-HSCT.
Abstract Introduction Graft-versus-host disease (GVHD) is a serious complication that markedly influences the prognosis of patients undergoi...
Mednext-based automatic segmentation of 18F-FDG PET images in angioimmunoblastic T-cell lymphoma and prognostic value exploration of predicted Total metabolic tumor volume
Abstract Objective:To evaluate MedNeXt, a deep learning network, for automated segmentation of 18F-FDG PET images in angioimmunoblastic T-ce...
Safety and effectiveness of standard versus extended duration of anticoagulation in children with acute lymphoblastic leukemia and venous thrombo-embolism
Abstract Background: Venous thrombo-embolism (VTE) occurs in up to 10% of pediatric patients with acute lymphoblastic leukemia (ALL). While a...
Real-world effectiveness of belumosudil for chronic GVHD by line of treatment: Analysis of academic and community practice patterns
Abstract Introduction: Belumosudil (BEL) is a ROCK2 inhibitor approved by the US FDA for the treatment of steroid-refrac...
Disease stigma and salivary stress biomarkers among adolescents and young adults with sickle cell disease
Abstract Introduction: Disease stigma is a known psychosocial stressor that impacts adolescents and young adults (AYA) living with sickle ce...
Renal and urinary adverse events following CAR-t therapy: A faers-based pharmacovigilance analysis
Abstract Background: CAR-T therapy is a transformative treatment for relapsed hematologic malignancies and is being explored for autoimmune...
A prospective non-randomized controlled study of vaseline-medicated gauze for topical management of chemotherapy-induced oral mucositis in pediatric hematology patients
Abstract Background: Chemotherapy-induced oral mucositis (CIOM) is a severe complication in pediatric hematologic malignancies, leading to t...
Palliative care consultation reduces hospital costs and length of stay among decedents with hematologic malignancies: A propensity score matched analysis from the national inpatient sample, 2016-2022
Abstract Introduction: Patients with hematologic malignancies face unique end-of-life challenges including rapid clinical deterioration, ong...
Cytomegalovirus (CMV) reactivation negatively impacts survival after CAR T-cell therapy in lymphoma patients: Results from the CART-SIE study
Abstract Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of relapsed/refractory B-cell lymphomas....
Children and adolescents with sickle cell disease demonstrate improved health-related quality of life and low decisional regret after hematopoietic cell transplantation: A sickle cell transplant advocacy and research alliance (STAR) study
Abstract Hematopoietic cell transplantation (HCT) for pediatric sickle cell disease (SCD) has steadily increased, however data on long-term...
Outcomes of splenectomy in benign and malignant hematologic conditions in the immunotherapy era
Abstract Introduction Splenectomy is utilized in benign and malignant hematologic conditions such as immune thrombocytopenic purpura, autoim...
The constant burden-aplastic anaemia as the underlying cause of death in older US adults- half century insights from the CDC wonder database (1968-2023)
Abstract Introduction: Aplastic Anemia is a serious blood disorder affecting roughly 2 persons per million in United Sta...
PI3Kδ inhibition enhances trametinib efficacy by suppressing feedback-activated PI3K/AKT signaling in PTPN11-mutant JMML
Abstract Juvenile myelomonocytic leukemia (JMML) is a rare but aggressive pediatric hematopoietic malignancy driven by mutations in the Ras...
Characterizing palliative care utilization among patients with Acute Myeloid Leukemia (AML): Insights from analysis of AML hospitalizations in the United States.
Abstract Introduction Acute Myeloid Leukemia (AML) is an aggressive form of hematological malignancy with an estimated five-year survival ra...