Blood
Articles in this Issue
Real-world efficacy and safety of venetoclax-based therapy in israeli patients with CLL/SLL: Results from the reveal study
Abstract Introduction Venetoclax-based therapy has significantly altered the treatment landscape for chronic lymphocytic...
#asheducation: Data and insights on social media's unique power for hematology education
Abstract Social media microlearning has emerged as an effective approach to medical education, offering concise, accessible educational cont...
Phase II trial of belantamab mafodotin, carfilzomib, pomalidomide, and dexamethasone in multiple myeloma following BCMA CAR T-cell therapy
Abstract Introduction: Treatment options are limited for patients who multiple myeloma (MM) relapses after B-cell maturation antigen (BCMA)-...
Clinical experience and safety of venetoclax in the treatment of patients with chronic lymphocytic leukemia in second and subsequent lines of therapy: Real-world data fron hemato-oncology centers of slovakia
Abstract Introduction: The treatment landscape for chronic lymphocytic leukemia (CLL) has significantly evolved in recent years, transitioni...
Feasibility of the edmonton symptom assessment system (ESAS) score as patient-reported outcomes (PROs) assessment in chronic myeloid leukemia patients receiving tyrosine kinase inhibitor therapy: A pilot Study
Abstract Introduction A substantial proportion of chronic myeloid leukemia (CML) patients experience tyrosine kinase inhibitor (TKI)-related...
Retrospective analysis in mortality from phlebitis/thrombophlebitis and atrial fibrillation/flutter in u.S. adults aged ≥45 years from 1999–2023: A CDC wonder study
Abstract Background: Atrial Fibrillation (AF) is characterized by irregular and often rapid heartbeats due to disorganized electrical activi...
The c-terminal to lish (CTLH) E3 ligase complex modulates myeloma glucocorticoid sensitivity by regulating nfkb signaling
Abstract Background: Glucocorticoids remain a cornerstone of frontline therapy for multiple myeloma (MM), yet resistance to these agents—par...
Single day long read whole genome sequencing for Acute Myeloid Leukemia
Abstract Introduction: Acute myeloid leukemia (AML) is considered a medical emergency and its management has evolved dra...
Senescence-prone immune cell subsets expand in the aged environment
Abstract Cellular senescence is an intriguing phenomenon in which cells enter cell cycle arrest and obtain peculiar properties upon encounte...
Impact of secondary FVIII prophylaxis on joint bleeding and arthropathy in a Hemophilia A mouse model lacking inhibitor response
Abstract Introduction: Hemophilia A (HA) is a severe bleeding disorder complicated by arthropathy of the large joints, due to synovial iron...
Machine learning based survival prediction of DLBCL: Using multimodal data.
Abstract Background: Diffuse-large B-cell lymphoma (DLBCL) is a heterogeneous disease with outcomes influenced by various clinical and molec...
Functional genomics studies identify determinants of response vs. resistance to pharmacological inhibitors of KRAS in multiple myeloma
Abstract Up to 50% of multiple myeloma (MM) patients harbor mutations of KRAS or NRAS. Pharmacologic inhibitors targeting specific KRAS muta...
Automated multi-source data consensus classification of low-frequency variants in hematologic malignancies using transparent artificial intelligence
Abstract Background: Evaluating the pathogenicity of a variant is challenging given the plethora of types of genetic evidence that laborator...
Excellent long-term outcomes after alemtuzumab-based hematopoietic cell transplantation (HCT) for severe aplastic anemia (SAA) and inherited bone marrow failure syndromes (IBMF): A 25-year British society of blood and marrow transplantation and cellular therapy (BSBMTCT) retrospective analysis of 1754 patients from the United Kingdom (UK)
Abstract Background: Allogeneic stem cell transplantation (HCT) is a curative option for patients with acquired severe aplastic anemia (SAA)...
Disrupting the global CAR T paradigm from the Middle East: Ultra-fast swift CAR T and scalable point-of-care manufacturing of autologous CAR T cells for hematologic malignancies
Abstract Background and Aims: CAR T-cell therapy has revolutionized treatment for CD19+ blood cancers, but conventional manufacturing is cos...
Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)
Abstract Introduction Acute myeloid leukemia (AML) is a rapidly progressive hematological malignancy characterized by the clonal proliferati...
Machine Learning–Based risk stratification in patients with direct anti‑xa Inhibitors–Related bleeding treated with four‑factor prothrombinex complex concentrate (4F-PCC)
Abstract Introduction: Patients taking direct oral anticoagulants (DOACs), including direct anti-Xa inhibitors, have risk of major bleeding...
Addition of venetoclax to hypomethylating agent offers limited incremental benefit for patients with treatment-naïve TP53-mutated myelodysplastic syndromes
Abstract Introduction Myelodysplastic syndromes (MDS) with TP53 mutations (mTP53) are characterized by suboptimal treatment response and dis...
STAG2 mutation preserves a stem cell phenotype in FLT3-ITD-mediated MDS to leukemia transformation
Abstract Acute myeloid leukemia with myelodysplastic related changes (AML-MRC) subtype is diagnosed when patients present leukemia with know...
A retrospective population-based study of long-term treatments and outcomes inwaldenstrom macroglobulinemia in Ontario, Canada
Abstract Introduction: Waldenstrom Macroglobulinemia (WM) is a rare B-cell malignancy characterized by periods of low burden disease not req...
Bone and region-specific targeting of SCF and CXCL12 in stromal niche cells reveals local and lineage-specific regulation of terminal hematopoiesis
Abstract LepR+ stromal cells in the bone marrow microenvironment produce essential regulatory factors like SCF-which promotes hematopoietic...
Additional genetic abnormalities (AGA) and microhomology end-joining DNA repair (MMEJ) signatures influence the outcome of newly diagnosed chronic phase (CP) CML: Ancillary study of the Trial of imatinib after ponatinib induction (TIPI)
Abstract Introduction: Recently, the presence of a variety of AGA to the BCR-ABL1 oncogene in CP-CML has been described to impair the prognos...
Beyond ECOG: Assessment of physical function enhances risk stratification prior to CAR-T cell therapy
Abstract Background The Eastern Cooperative Oncology Group performance status (ECOG PS) represents the standard for asse...
Combined TCR-seq and single-cell RNA-seq reveal distinct origins for antiviral immunity after post-transplant cyclophosphamide and tac/MTX gvhd prophylaxis: Results from the BMT CTN 1801 study
Abstract Background: A randomized multicenter trial (BMT CTN 1703) demonstrated that after reduced intensity conditioning HCT, PT-Cy-based G...
The antibiotic linezolid targets the Jak2V617F mutation in polycythemia vera.
Abstract Current treatment options for polycythemia vera (PV) patients suppress excessive hematopoiesis, but lack specificity against JAK2V6...