Blood
Articles in this Issue
Comparative effectiveness and safety of apixaban vs. rivaroxaban in patients with cirrhosis and portal vein thrombosis: An analysis of real-world data
Abstract Background: Portal vein thrombosis (PVT) affects approximately 14% of cirrhosis patients and is associated with increased morbidity...
Association between comorbid depression and antidepressant adherence with adherence to disease-modifying therapies in patients with sickle cell disease in Texas Medicaid
Abstract Introduction: Depression is a prevalent mental health condition among patients with sickle cell disease (SCD) and is associated wit...
Dissecting how pulmonary remodeling from cigarette smoke impacts clonal hematopoiesis
Abstract Certain somatic mutations result in clonal expansion of mutated hematopoietic cells — the phenomenon known as clonal hematopoiesis...
Perceived treatment and clinical trial access barriers in relapsed/refractory (R/R) follicular lymphoma: Findings from a national survey
Abstract Background: Follicular lymphoma (FL) is a relapsing, incurable B-cell non-Hodgkin lymphoma with increasing treatment complexity in...
Isa-PACE in the treatment of functionally high-risk multiple myeloma: Intermediate results.
Abstract Introduction. The VRd regimen with autologous hematopoietic stem-cell transplantation (auto-HSCT) is the standard treatment for new...
A rare case of idiopathic non-cirrhotic portal HTN in a patient with idiopathic thrombocytopenia purpura
Abstract Introduction: Idiopathic non-cirrhotic portal hypertension (INCPH) is a rare condition characterized by clinical portal hypertensio...
Venetoclax-based salvage therapy achieves high remission rates after 7+3 or low-dose cytarabine
Abstract Introduction: In the Brazilian public health system (SUS), salvage chemotherapy for fit patients with relapsed/refractory (R/R) acu...
Mosunetuzumab and polatuzumab combined with axicabtagene ciloleucel induce high complete response rates at day+90 in Relapsed/Refractory large B-cell lymphoma
Abstract Introduction CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy has become a standard of care for patients (pts) with r...
Structural insights of stomatin from native human platelets by cryo-EM coupled with “Build and Retrieve” (BaR) data processing.
Abstract Background: Stomatin is an integral membrane protein known for cholesterol binding, membrane stiffening, regulating ion channel act...
MLLT1/3 targeted protein degradation as the best-in-class approach for targeting the super elongation complex (SEC) in acute leukemia, including menin inhibitor refractory disease
Abstract Background: MLLT1 and 3 are highly homologous histone reader and scaffolding proteins, with sole known roles as critical regulators...
5-HT prompt TPO mRNA transcription via H3Q5 serotonylation
Abstract Background: 5-HT (serotonin) is considered as a novel cell growth factor. Our previous studies have shown that 5-HT is a pleiotropi...
Erythroblastic sarcoma transformation from chronic myeloid leukaemia: A case report
Abstract Introduction: Erythroblastic sarcoma (ES) is a rare form of myeloid sarcoma(MS). We report an unusual case of ES transforming from...
Mitochondrial dysfunction as a key factor in the predisposition to 14q32-related myeloid hematological malignancies
Abstract Myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes, and acute myeloid leukemia (AML), ar...
Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome
Abstract Introduction Acute chest syndrome (ACS), the second most common complication of sickle cell disease (SCD), is c...
A phase 2 trial of abbreviated fixed-duration (Default 4 Cycles) linvoseltamab immuno-consolidation to deepen responses post newly diagnosed multiple myeloma combination therapy for minimal residual disease positivity (the IMMUNOPLANT Study)
Abstract Background : Proteosome inhibitor (PI), immunomodulatory drug (IMiD), and anti- CD38-based quadruplet (quad) therapies have revolut...
TDI01 in the treatment of moderate to severe chronic graft-versus-host disease: Updated results from a multicenter, OPEN-label phase IB/II study (An Update)
Abstract Introduction:This multicenter, open-label Phase Ib/II study evaluated TDI01 in patients with moderate or severe chronic graft-versu...
Single-arm meta-analysis of melflufen-based regimens in relapsed/refractory multiple myeloma: Efficacy and safety insights from clinical trials
Abstract Introduction: Multiple Myeloma (MM) poses a significant challenge in clinical settings, especially among patients with resistant di...
Donor and recipient age-related differences in immunological reconstitution affect development of chronic graft-versus-host disease
Abstract Background: Donor source (p=0.032) and patient age (p=0.015) were associated with onset of chronic graft-versus-host disease (cGVHD...
Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials
Abstract Objective: Tumor-targeted drug monotherapy or chemotherapy is becoming increasingly important in cancer treatment, yet the concomit...
First-line ibrutinib + venetoclax shows benefit across genomic subgroups in patients with chronic lymphocytic leukemia (CLL): Results from Phase 2 captivate study and Phase 3 glow study
Abstract Introduction: Genomic alterations, including IGHV mutation status, are predictive for outcomes on chemoimmunotherapy in CLL. Here w...
Elranatamab real-world step-up dosing patterns in relapsed-refractory multiple myeloma patients: Interim analysis Results of the AMbreLA study
Abstract Introduction Elranatamab (ELRA) is a humanized, bispecific antibody that targets both B-cell maturation antigen (BCMA) on multiple...
The addition of venetoclax to FLAG IDA or FCE in relapsed or refractory (R/R) acute myeloid leukemia (AML)
Abstract Background The addition of venetoclax (ven) to intensive chemotherapy (IC) has shown high remission rates in bo...
A functional CAR-T cell atlas to unravel regulatory mechanisms of CAR-T therapies
Abstract Introduction: Over the past decade, CAR-T therapies have emerged as a groundbreaking treatment for cancer, showing remarkable effic...
Son maintains innate immune homeostasis in HSCs via splicing and retroelement control
Abstract Hematopoietic stem cells (HSC) maintain blood homeostasis during steady state and stress through a balanced regulation of self-rene...
Characteristics and prognostic factors in adult hemophagocytic lymphohistiocytosis: A large single-institution analysis
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening hyperinflammatory syndrome resulting from imm...