Blood
Articles in this Issue
Acute myeloid leukemia with 4q12 rearrangements does not involve pdgfra
Abstract Background:Chromosome 4q12 rearrangements are recurrent molecular alterations in hematologic malignancies, and the most common onco...
HMG-CoA reductase inhibitors and the attenuation of risk for disseminated intravascular coagulation in patients with sepsis: Secondary analysis finds no change in the index outcome based on reason for statin prescription
Abstract 'HMG-CoA reductase inhibitors and the attenuation of risk for disseminated intravascular coagulation in patients with sepsis’ publi...
Evaluation of the American society of hematology quality improvement training institute: Impact on learner quality improvement knowledge, confidence, and satisfaction
Abstract Background: The American Society of Hematology (ASH) Quality Improvement Training Institute (QITI) launched in March 2024 to build...
Rapid JAK2 V617F decline predicts response durability: Kinetics of JAK2 V617F in ropeginterferon alfa-2b treated polycythemia vera
Abstract Background: Polycythemia Vera (PV) is a hematopoietic stem cell (HSC) neoplasm defined by the JAK2 V617F mutation, characterized by...
CMML2AML: Machine-learning discovery of co-mutations predictive of blast transformation in chronic myelomonocytic leukemia
Abstract Background Blast transformation (BT) occurs in approximately 15-30% of patients with chronic myelomonocytic leukemia (CMML) and rema...
Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression
Abstract Introduction . Chronic lymphocytic leukemia (CLL) cells bidirectionally interacts with the tumor microenvironment (TME). Leukemic ce...
Cancer specific risk and mortality due to autoimmune hemolytic anemia (AIHA) associated with immune checkpoint inhibitors (ICI)
Abstract Background Immune checkpoint inhibitors (ICI) are cornerstone of treatment of majority of the solid cancers wit...
Prospera (ABNL-MARRO 002): A randomized phase 2 study of pacritinib vs. hydroxyurea in patients with advanced proliferative chronic myelomonocytic leukemia (CMML)
Abstract Background and Significance: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy with overlapping dysplastic...
A CRISPR screen in enucleated human red cells identifies CLIC3 and VAMP8 as critical regulators of terminal erythropoiesis
Abstract During terminal erythroid differentiation, committed precursor cells proliferate and differentiate down the erythroid lineage, yiel...
Efficacy and safety of orelabrutinib monotherapy in patients with chronic lymphocytic leukemia: A retrospective real-world study
Abstract Introduction: Chronic lymphocytic leukaemia (CLL), a hematologic malignancy of B cells, is one of the most freq...
CD5 positivity and aberrant P53 expression predict primary refractoriness to first-line pola-R-CHP in patients with diffuse large B-cell lymphoma
Abstract Background: The Pola-R-CHP regimen has emerged as an effective initial treatment for patients with newly diagnosed diffuse large B-...
Pilot study of cell-free DNA (cfDNA) for measurable residual disease monitoring following autologous hematopoietic cell transplant in multiple myeloma
Abstract Introduction Measurable residual disease (MRD) in bone marrow has become an important surrogate endpoint in multiple myeloma studie...
Blinatumomab and ponatinib vs. hyper-CVAD and ponatinib in patients with Philadelphia-chromosome positive acute lymphoblastic leukemia: A propensity score analysis
Abstract Introduction: The outcome of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has dras...
Immunological biomarkers and TARC/CCL17 in myelodysplastic syndrome: Insights into immune microenvironment regulation
Abstract Background: Immune dysregulation is central to myelodysplastic syndrome (MDS) pathogenesis, with inflammatory cytokines and chemoki...
CAR T-cell therapy for refractory/relapsed primary breast lymphoma: A retrospective cohort study
Abstract Abstract Background: Patients with primary breast lymphoma (PBL) who are refractory to initial therapy or who r...
Efficacy and safety of aponermin combined with immunomodulators in relapsed/refractory multiple myeloma
Abstract Background Patients with relapsed/refractory multiple myeloma (RRMM) are prone to drug resistance after multiple lines of treatment...
Pharmacokinetic and pharmacodynamic characteristics of emicizumab in Chinese pediatric patients with hemophilia A: A retrospective single-center study
Abstract Background Emicizumab, a bispecific monoclonal antibody that mimics activated FVIII, is now the standard prophylaxis for hemophilia...
Expression of the cancer testis antigen PRAME is associated with response to immune checkpoint inhibitor and rituximab priming in treatment-naïve diffuse large B-cell lymphoma
Abstract Introduction Diffuse large B-cell lymphoma (DLBCL) is clinically and biologically heterogenous. Though immune c...
Efficacy of a venetoclax-based, anthracycline-free regimen in newly diagnosed CBFβ::MYH11(+) acute myeloid leukemia
Abstract Background: Induction with cytarabine/anthracycline-based regimen (7+3 regimen) followed by consolidation with high-dose cytarabine...
Immature platelet fraction as a marker for romiplostim discontinuation in immune thrombocytopenia: Experience from cuenca, Ecuador
Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist used as a second-line treatment for primary immune thrombocytopenia...
Apoptotic rewiring via PI3K hyperactivation as a therapeutic strategy in B-cell malignancies
Abstract Background and Significance: PTEN is a critical negative regulator of PI3K/AKT signaling that dephosphorylates PI(3,4,5)P3 to PI(4,...
Adult acute myeloid leukaemia with DDX3X::MLLT10: A rare entity with significant unmet clinical needs
Abstract Background DDX3X and MLLT10 genes are located on chromosomes X and 10, respectively. In a study of 2,080 children and young adults...
Outcomes in pediatric patients with HSCT-TMA treated with ravulizumab
Abstract Background: Hematopoietic stem cell transplantation–associated thrombotic microangiopathy (HSCT-TMA) is a rare, life-threatening co...
Methionine promotes glycolysis and tumor progression in multiple myeloma by enhancing POU2AF1 expression via m⁶A modification
Abstract INTRODUCTION: Multiple myeloma (MM), the second most prevalent hematologic malignancy, is characterized by the abnormal proliferati...
Locational patterns and ecological catalysts of cutaneous T-cell lymphoma: Insights from a Louisiana medical center (2019–2024)
Abstract Background Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma that primarily affects the skin, caused by malig...