Blood
Articles in this Issue
Evaluation of ventoclax initiation prophylaxis and monitoring outcomes at each dose level and time point in patients with chronic lymphocytic leukemia: A real-world experience
Abstract Background: Venetoclax (VEN)+obinutuzumab (VO) is an effective therapy for CLL/SLL requiring regular monitoring for tumor lysis synd...
Perturbation of iNKT differentiation during clonal hematopoiesis from rewiring of inflammation and lipid presentation
Abstract Invariant Natural Killer T (iNKT) cells are a rare, non-conventional T cell subset that recognize lipid antigens presented by the M...
Underexplored mutations in plasma cell myeloma
Abstract Background: Mutation testing with Next Generation Sequencing (NGS) is routinely used for risk stratification at the time of diagnosi...
A target trial emulation to assess the comparative incidences of venous thromboembolism in patients with chemotherapy induced thrombocytopenia treated with romiplostim.
Abstract Introduction Chemotherapy induced thrombocytopenia (CIT) commonly occurs in patients with solid tumors often resulting in dosage re...
Pembrolizumab + GVD with ctdna-guided consolidation for relapsed/refractory classic Hodgkin lymphoma: A multicenter phase 2 Study of the University of California hematologic malignancies consortium
Abstract The current standard of care for relapsed/refractory classic Hodgkin lymphoma (R/R cHL) is salvage chemotherapy followed by autolog...
Alpha-thalassemia and red blood cell heterogeneity in sickle cell trait: Interim findings from the achieving understanding of the natural history of sickle cell trait (AUNT) study
Abstract Introduction: Heterozygous inheritance of hemoglobin S (HbAS) is known as sickle cell trait (SCT). While most individuals with SCT...
Real-world patient characteristics, treatment patterns, and outcomes in patients with myelodysplastic syndromes
Abstract Background: Due to its rarity and heterogeneity, management of myelodysplastic syndrome (MDS) can be challengin...
Efficacy and safety of rocbrutinib, the fourth generation bruton's tyrosine kinase inhibitor, in patients with BTK inhibitor pre-treated relapsed or refractory Mantle Cell Lymphoma: Results from a Phase II rock-1 trial
Abstract Introduction Patients with relapsed or refractory mantle cell lymphoma (r/r MCL) following prior covalent Bruton tyrosine kinase in...
Overcoming therapy resistance with multi-targeted CAR-T cells secreting bispecific antibody (BsAb) for the treatment of B-cell malignancies
Abstract Adoptive T-cell immunotherapies have revolutionized the treatment landscape for aggressive B-cell malignancies. Despite high rates...
Impact of anti-thymocyte globulin on graft-versus-host disease risk among HLA-matched related donors undergoing allogeneic hematopoietic cell transplantation for aplastic anemia
Abstract Introduction: Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder curable with allogeneic hematopoietic...
Erythroid PIM1 deficiency promotes hematopoietic aging via jun/jund activation and igkc-mediated proteostasis collapse
Abstract Anemia, the most prevalent hematological disorder in the elderly, commonly presents with accelerated aging phenotypes in severe cas...
ICE therapy for primary and secondary central nervous system involvement of lymphomas
Abstract Central nervous system (CNS) lymphomas, including primary CNS lymphoma (PCNSL) and secondary CNS lymphoma (sCNSL), are aggressive a...
Anti-CD19 CAR-T cells for Mantle Cell Lymphoma with central nervous system involvement: A study of the french descart registry.
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has recently shown promise in treating diffuse large...
Targeted hyperactivation of oncogenic STAT5-signaling in acute lymphoblastic leukemia
Abstract Background and Significance: Oncogenic tyrosine kinases activate STAT5a and STAT5b to promote survival and proliferation in acute l...
Polatuzumab vedotin combined with orelabrutinib and rituximab (PRO Regimen) as frontline therapy in elderly and frail patients with diffuse large B-cell lymphoma (DLBCL): Results from A phase II study
Abstract Title: Polatuzumab Vedotin Combined with Orelabrutinib and Rituximab (PRO Regimen) as Frontline Therapy in Elderly and Frail Patien...
Inhibition of prolyl-tRNA synthetase sensitizes acute myeloid leukemia to venetoclax through bmf-mediated apoptosis
Abstract Acute myeloid leukemia (AML) is an aggressive hematologic malignancy associated with a poor prognosis. Despite recent advances in t...
Generation of faithful autochthonous mouse models of Mantle Cell Lymphoma
Abstract Introduction: MantleCell Lymphoma (MCL) is characterized by the translocation t(11;14) resulting in overexpression of Cyclin D1. Ot...
Estimating incidence and prevalence of polycythemia vera and associated eligibility for cytoreductive therapies in major US health plans
Abstract Introduction: Polycythemia vera (PV) is a rare myeloproliferative neoplasm (MPN) characterized by elevated red blood cell productio...
Clinical impact of FLT3 microclones on outcomes in patients with newly diagnosed FLT3-ITD negative AML: A subanalysis from the pethema quiwi trial
Abstract Background: FLT3-ITD negative acute myeloid leukemia (AML) remains challenging to treat, with limited targeted therapeutic options...
CD44v6 promotes anti-apoptotic phenotypes in AML via an SPP1-mediated autocrine activation of the MAPK-dusp pathway
Abstract Background:Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy originating from the bone marrow. Comple...
Myelodysplastic/myeloproliferative overlap neoplasms: Clinicopathological features, treatment strategies, and outcomes — a UK multicentre cohort Study
Abstract Background: Myelodysplastic/Myeloproliferative overlap neoplasms (MDS/MPN) are rare, clonal malignancies displaying clinicopatholog...
A prospecitive, multicenter study of chidamide in adult patients with refractory primary immune thrombocytopenia
Abstract Background: Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder. Our preclinical data revealed that c...
Cutaneous and peripheral T-cell lymphomas in the u.S. population: A 25-year national review of epidemiological burden and racialdisparities
Abstract Cutaneous and Peripheral T-cell Lymphomas in the U.S. population: A 25-Year National Review of Epidemiological Burden and Racial Di...
Lipoprotein(a) plasma levels and coagulation biomarkers: Results from a comprehensive laboratory assessment in an angiographically-controlled cardiovascular cohort.
Abstract Background: lipoprotein(a) [Lp(a)] is an established risk factor for cardiovascular disease. Among the molecular mechanisms underly...
Transfusion independence, hematological improvement and associated safety outcomes with bexmarilimab and azacitidine in HR-MDS: Results of the bexmab Phase 1/2 study
Abstract Introduction Hypomethylating (HMA) agents, including azacitidine, are standard frontline agents for HR MDS pati...