Blood
Articles in this Issue
Preclinical evaluation of SWI/SNF targeting agents in multiple myeloma including t(4;14) subtypes
Abstract Introduction: Despite remarkable advances in treatment, patients with multiple myeloma (MM) continue to suffer relapse. Therefore,...
Longitudinal single-cell profiling in canine DLBCL reveals regulatory networks driving chemotherapy resistance.
Abstract Diffuse Large B Cell Lymphoma (DLBCL) is the most common lymphoid malignancy in both humans and dogs, characterized by clinical and...
Impact of hereditary predisposition genes to hematologic malignancies on transplant outcomes and donor selection
Abstract Impact of Hereditary Predisposition Genes to Hematologic Malignancies on Transplant Outcomes and Donor Selection Background: With t...
Real-world treatment patterns and outcomes among patients with newly diagnosed NPM1-mutated acute myeloid leukemia in the United States
Abstract Introduction: Approximately 30% of adults with acute myeloid leukemia (AML) have nucleophosmin 1 mutations (NPM1m). However, standar...
Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.
Abstract Background Disease relapse is a major challenge for acute myeloid leukemia patients after allogeneic hematopoietic cell transplanta...
Real-world effectiveness of gilteritinib beyond second-line therapy in relapsed/refractory FLT3-mutated acute myeloid leukemia: A european multicenter study of 171 patients
Abstract Background: Gilteritinib is a selective FLT3 inhibitor approved for the treatment of relapsed or refractory (R/R) FLT3-mutated acut...
Understanding health literacy among patients with thalassemia: Results from a global patient survey by the Thalassemia Advocacy Advisory Council
Abstract Introduction: Despite advances in the management of thalassemia, a rare and under-recognized hereditary anemia, unmet needs remain...
Successful melphalan flufenamide (melflufen) therapy in patients with severe renal insufficiency
Abstract Background: Multiple myeloma (MM) is a malignant and heterogenous plasma cell disorder. It is characterized by the clonal prolifera...
Mass spectrometry demonstrates very frequent multi-clonality in familial Waldenström macroglobulinemia and shows distinct IgM profiles across IgM-related disorders.
Abstract Introduction: Waldenström macroglobulinemia (WM) is clinically heterogeneous with a subset of patients experiencing IgM-driven comp...
The T cell immunosenescence profile of patients with newly diagnosed multiple myeloma as an indicator of frailty: Preliminary data from the immuno-NDMM protocol.
Abstract BACKGROUND Fit and young (< 65 years) patients (pts) with newly diagnosed Multiple Myeloma (NDMM) are candidates to high dos...
Improved hematopoietic stem cell mobilization for gene therapy using single agent motixafortide in sickle cell disease
Abstract While the development and approval of gene therapies (GT) for sickle cell disease (SCD) has transformed treatment options for patie...
Effect of pre-allogeneic HCT splenic irradiation on post-transplant engraftment and outcomes in patients with myelofibrosis: A single-center experience
Abstract Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is the only curative option for myelofibro...
Current practices of anticoagulant utilization in pediatric patients with acute myeloid leukemia (AML)
Abstract Introduction: Management of thromboembolism (TE) in pediatric acute myeloid leukemia (AML) is challenging due to prolonged periods...
Quality-adjusted survival analysis of neurologic events with ciltacabtagene autoleucel (Cilta-cel) vs standard of care (SOC) in patients (Pts) with lenalidomide-refractory multiple myeloma (MM) who received 1–3 prior lines of therapy (LOT): Cartitude-4 trial population (Pop)
Abstract Introduction: A single infusion of cilta-cel demonstrated significant improvement in overall survival (OS) vs SOC in pts with lenal...
Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Transformed Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma: a DESCAR-T Registry and International Collaborative Study
Abstract Introduction: The prognosis of patients (pts) with histological transformation (HT) of Waldenström macroglobulinemia (WM) remains d...
Downregulation of TANK gene affects erythroid differentiation in PNH patients.
Abstract Background:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disease of hematopoietic stem cells characterized by com...
Clonal hematopoiesis and immune dysregulation in classic PNH
Abstract Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder originating from somatic mutations in PIGA wit...
Temporal trends in mortality from hematological cancers with atrial fibrillation and flutter as contributing causes in the United States, 2000–2020: A national vital statistics system analysis
Abstract Background: Hematological malignancies pose a significant public health burden, with atrial fibrillation/flutter (AF/AFL) increasin...
Bone marrow immune and stromal niche remodeling in myelodysplastic neoplasm patients under erythropoietic therapies by 29-color full-spectrum flow cytometry
Abstract INTRODUCTION Despite immune and stromal components of the bone marrow (BM) niche are increasingly recognized as key regulators in my...
Antiplatelet therapy in anticoagulated cirrhotic patients with chronic portal vein thrombosis: A retrospective multicenter study
Abstract Background: Treatment of chronic portal vein thrombosis (PVT) in cirrhotic patients can be complicated, mainly...
Optimizing establishment of high need pediatric Acute Myeloid Leukemia (AML) patient derived xenograft (PDX) models
Abstract Introduction: Pediatric acute myeloid leukemia (pAML) patient-derived xenograft (PDX) models are vital for pre-clinical evaluation...
Elucidating the role of retrotransposon-mediated viral mimicry in leukemia therapy
Abstract Hypomethylation agents (HMA), including 5-azacytidine (AZA) and decitabine (DAC), are frontline therapies for myelodysplastic syndr...
Isatuximab subcutaneous in relapsed/refractory multiple myeloma: Exposure-response and serum m-protein dynamics analyses from phase 3 iraklia Study and the phase 1b Study
Abstract Introduction: The first Phase (Ph) 3 study in multiple myeloma (MM) using an on-body injector (OBI), IRAKLIA (NCT05405166), is a ra...
Impact of therapy delays on outcomes in adults with BCR::ABL1 negative b-lineage acute lymphoblastic leukemia (ALL) in the ECOG-ACRIN E1910 trial randomized to conventional chemotherapy +/- blinatumomab
Abstract Background: The addition of the CD19/CD3 bispecific T-cell engager, blinatumomab, to standard consolidation chemotherapy in adults...
Impact of high-dose methotrexate in both central nervous system relapse and systemic progression in high-risk DLBCL: A retrospective analysis of a brazilian cohort
Abstract Background: Central nervous system (CNS) relapse in diffuse large B-cell lymphoma (DLBCL) is a rare but devastating event, with dism...