Blood
Articles in this Issue
The efficacy and safety of venetoclax-based and anthracycline-free induction therapy followed by allogeneic hematopoietic stem cell transplantation in the treatment of transplant-eligible Acute Myeloid Leukemia patients
Abstract Background The standard treatment of transplant-eligible acute myeloid leukemia is intensive anthracycline plus...
Tumor necrosis factor-alpha (TNFα) drives pathologic platelet hyperreactivity through signaling on hematopoietic stem/progenitor cells and expansion of canonical megakaryocytic progenitors.
Abstract Tumor necrosis factor-alpha (TNFα) has multiple roles for signaling inflammation and its two receptors, TNFαR1 and TNFαR2 exhibit a...
Functional analyses of vitt patient-derived PF4-antibodies and adenoviral vaccine compounds reveal unique patient-specific profiles of multicellular activation
Abstract Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but life-threatening adverse reaction to COVID-19 vaccines resulting i...
Characterization of patients with restrictive patterns of lung disease following allogeneic hematopoietic stem cell transplantation
Abstract Background: As mounting numbers of patients receive allogeneic hematopoetic stem cell transplantation (allo-SCT) for hematologic ma...
Multi-dimensional transcriptomic profiling reveals novel tumor microenvironment landscape and subtype-specific therapeutic Vulnerabilities of MALT lymphomas
Abstract Introduction: Mucosa-associated lymphoid tissue (MALT) lymphoma is the most prevalent subtype of marginal zone lymphomas and can pr...
Germline predisposition in pediatric malignancies: Insights from a retrospective study at Dana-Farber Cancer Institute
Abstract Introduction Germline genetic testing is increasingly recommended at the time of a pediatric cancer diagnosis for children with soli...
Clinicopathological features and prognostic analysis of non-Hodgkin's lymphoma with paraproteins: A single-center retrospective study
Abstract Objective: In the 5th edition of the WHO Classification of Haematolymphoid Tumors (WHO-HAEM5), other diseases with paraproteins tha...
Assessing the impact of distance from primary hemophilia treatment center on annualized bleeding rates in people with inheritable bleeding disorders
Abstract Introduction: Access to federally-supported hemophilia treatment centers (HTC) is critically important in people with inheritable b...
Embedding narrative medicine into subspecialty training: A novel clinical rotation to foster humanism, empathy, and systems awareness
Abstract Introduction Across medical subspecialties—including hematology—there is rising concern about declining empathy...
A single-institution retrospective analysis of allo-HSCT for relapsed and refractory aggressive lymphomas: T-cell origin predicts better outcomes even in active disease.
Abstract Introduction: Relapsed and refractory (r/r) aggressive lymphoma remains a therapeutic challenge. In recent years, chimeric antigen...
Efficacy of levetiracetam prophylaxis in blinatumomab-induced neuro-toxicities in acute lymphoblastic leukemia: Retrospective single-arm cohort study
Abstract Background: Blinatumomab, a CD19x3 bispecific T cell engager, shows efficacy for B-cell acute lymphoblastic leu...
Etiologic heterogeneity in secondary hemophagocytic lymphohistiocytosis: A retrospective real-world study from a quaternary academic center
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome marked by excessive immune activati...
Mass spectrometry-based molecular investigation identifies key proteins involved in synergistic AXL and BCL-2 dual inhibition for Acute Myeloid Leukemia
Abstract Background The 5-year survival rate for AML patients remains around 30%, with drug resistance being a significant challenge. Overex...
The prospect of high-dose vitamin c in improving early survival in patients with hemophagocytic lymphohistiocytosis
Abstract Introduction Hemophagocytic lymphohistiocytosis (HLH) is a severe disease incited by an inflammatory cytokine s...
FLT3 inhibition with midostaurin offsets poor prognosis in NPM1/FLT3/DNMT3a triple-mutated AML
Abstract Context: FLT3 mutated (FLT3m) AML with co-occurring mutations in DNMT3a and NPM1 (triple mutated) have been identified to be a subs...
Butyrate up-regulates the expression of CDKN1A to block the cell cycle and inhibits the PI3K-AKT signaling pathway to promote apoptosis to play an anti-Acute Myeloid Leukemia role
Abstract BACKGROUND Our previous research indicated a significant reduction in the beneficial metabolite butyrate acid,...
Toxicity and efficacy profile of cardioprotective vs conventional doxorubicin: A meta-analysis
Abstract INTRODUCTION: Anthracycline induced toxicity is a well known consequence of dose related cumulative effects accounting to cardiotox...
Remote therapeutic monitoring reduces hospitalization due to infection in patients being treated for hematological malignancy
Abstract Background: In patients with hematological malignancies, infections due to treatment toxicities or underlying disease are a common...
Immunosuppressive T-cell landscape in myelodysplastic Neoplasms with TP53 mutations
Abstract Background TP53 mutations were common genomic alterations in myelodysplastic neoplasms (MDS) and associated with adverse prognosis....
Functional classification of monoallelic TP53 mutations refines prognostic stratification in myelodysplastic neoplasms
Abstract Introduction Myelodysplastic neoplasms (MDS) are a group of hematological disorders characterized by ineffectiv...
Digital PCR-based dynamic monitoring of JAK2V617F burden: A decade-long study unravels its prognostic value in MPN treatment response
Abstract Background: The JAK2V617F mutation is a key driver mutation in myeloproliferative neoplasms (MPNs), and its dynamic changes may ref...
Trends in triplet and quadruplet regimen utilization among patients with newly diagnosed multiple myeloma during 2017-2024
Abstract Background: Treatment options for multiple myeloma have evolved rapidly, but little is known about the trends in novel triplet and...
Harnessing BCL2 inhibition with BTK inhibition in follicular lymphoma: A translational trial with mechanistic insights from single cell analysis
Abstract Background: Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, remains incurable despite initial responsivenes...
Molecular risk stratification of myelodysplastic syndromes in Brazil: A cohort applying IPSS-m and taxonomic classification
Abstract Myelodysplastic syndromes (MDS) remain underrepresented in epidemiologic research from Latin America. Large studies such as Belli e...
RNA editing of H19 shapes hematopoietic stem cell function and differentiation via cell cycle regulation
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a key post-transcriptional modification involved in immune response and cell fate dete...