Blood
Articles in this Issue
Assessment of EBV DNA methlyation to guide antiviral use in EBV-associated lymphoma
Abstract Intro/Objective: Epstein-Barr Virus (EBV), an oncogenic herpesvirus, can drive human lymphoma development. EBV uses DNA methylation...
HMGA1 chromatin regulators drive transcriptional networks governing cell cycle progression, immune escape, and menin-inhibitor resistance in KMT2A-r Acute Myeloid Leukemia
Abstract Introduction: KMT2A-rearranged acute myeloid leukemias (KMT2A-r AML) are highly lethal leukemias caused by rearrangements of the KM...
Successful surgical management in severe hemophilia A patients using efanesoctocog alfa: A two-case experience undergoing orthopedic surgery
Abstract Introduction: Efanesoctocog alfa (Altuviiio®/Altuvoct®) is a newly approved, high-sustained recombinant factor VIII (rFVIII) with u...
Homoharringtonine added to CLAG regimen improves outcome of pediatric Relapsed/Refractory AML: A multicenter prospective study
Abstract Induction The prognosis of refractory/relapsed (R/R) Acute myeloid leukemia (AML) is dismal. Regimens including cladribine, cytarab...
Clinical characteristics and outcomes of children with T-cell acute lymphoblastic leukemia harboring ABL-class fusions: A report from the ponte di legno consortium
Abstract Introduction: ABL-class acute lymphoblastic leukemia (ALL) is characterized by rearrangements of ABL1 or other...
The laminin receptor integrin α7β1 marks a highly migratory cell population and correlates with poor prognosis in Acute Myeloid Leukemia.
Abstract Introduction: Interactions with the bone marrow (BM) niche are crucial for self-renewal and survival of acute myeloid leukemia (AML)...
National trends and demographic disparities in perinatal non-traumatic intracranial hemorrhage mortality in the United States, 1999–2024
Abstract Background Non-traumatic intracranial hemorrhage (ICH) during the perinatal period is associated with substanti...
Treatment initiation and first line tyrosine kinase inhibitor (TKI) selection for older patients with newly diagnosed chronic myeloid leukemia (CML) in the United States (US) before and after the introduction of generic imatinib (GE-IMA)
Abstract RW, JMS co-first authors; XM, NP co-senior authors Background The first-generation TKI imatinib (IMA) is the mo...
Late onset and long lasting neutropenia & primary immune-dysregulation : Early signals & genetic connections
Abstract Background. Children affected with neutropenia that appears after age 5 years (Late Onset neutropenia, LO-Np) or lasts longer than...
Risk factors associated with intraparenchymal hemorrhage in patients with acute leukemia
Abstract Background: Intraparenchymal hemorrhage (IPH) is one of the most morbid complications of patients presenting with acute leukemia 1-...
Pirtobrutinib in post-cbtki CLL/SLL: Final update from the Phase 1/2 BRUIN study with more than 5 years follow-up
Abstract Background: Covalent Bruton tyrosine kinase inhibitors (cBTKi) have dramatically changed the treatment (tx) landscape of chronic ly...
Utilization and outcomes of inferior vena cava (IVC) filters in patients with cancer-associated acute venous thromboembolism hospitalizations: Insights from the u.S. national inpatient sample 2018–2022
Abstract BACKGROUND AND OBJECTIVE Cancer patients with acute venous thromboembolism (VTE) have complex management needs, and the use of infer...
Macrophage subsets provide distinct niches for normal and clonal hematopoiesis
Abstract Hematopoietic stem cells (HSCs) are tightly regulated by the bone marrow (BM) niche to ensure blood homeostasis. Dysfunction of the...
Blood board: A virtual forum for classical hematology education and care improvement
Abstract Introduction: The landscape of classical hematology has undergone substantial evolution over the last decade, marked by new diagnos...
Prognostic analysis of newly diagnosed systemic light-chain amyloidosis patients treated with daratumumab
Abstract Systemic light-chain (AL) amyloidosis is a rare disorder characterized by deposition of misfolded monoclonal immunoglobulin light c...
Determining the origin of TP53 mutations in patients with mature B-cell neoplasms is essential to distinguish lymphoma-related mutations from those due to clonal hematopoiesis, helping to guide treatment decisions
Abstract Background: Mutations (mut) in the TP53 gene are found in distinct mature B-cell neoplasms (B-NHL) and are frequently associated wi...
Molecular risk stratification and MRD-guided consolidation determine outcomes in pediatric non-down syndrome acute megakaryoblastic leukemia: A multicentre Chinese cohort study
Abstract Background: Management of pediatric acute megakaryoblastic leukemia (AMKL) without Down syndrome (non-DS-AMKL) remains challenging...
Hairy cell leukemia treatment strategies: A real-world multicenter experience
Abstract Background Hairy cell leukemia (HCL) is a rare, indolent B-cell malignancy accounting for ~1% of all lymphoid n...
Prophylactic rituximab administered on day -1 during conditioning significantly reduces early EBV reactivation in pediatric allogeneic HSCT: Real-world evidence from a propensity-matched cohort of 834 patients
Abstract Background: Epstein–Barr virus (EBV) reactivation is a common and serious complication after pediatric allogeneic hematopoietic ste...
Epidemiology of cancer-associated bleeding in a nationwide electronic health record database
Abstract Background People with cancer frequently experience hemostatic imbalances that result in excessive clotting or bleeding. While the...
Bioequivalence of ruxolitinib once-daily extended-release vs twice-daily immediate-release tablets in healthy adults
Abstract Background: Ruxolitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of adults with intermediate/high-r...
TCF-1 overexpression enhances CD19.CAR-T cell potency by attenuating activation-induced cell death
Abstract Background The chimeric antigen receptor T cell targeting CD19 (CD19.CAR-T) has demonstrated encouraging therapeutic efficacy in tr...
Clinical translation of single cell measurable residual disease (scMRD) assay in real world Acute Myeloid Leukemia (AML) patients
Abstract In this study, we aimed to analyze the prognostic potential of a single-cell MRD (scMRD) assay in a prospective cohort of real worl...
Unannotated open reading frames expand the antigen repertoire in T cell acute lymphoblastic leukemia
Abstract Background: T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy in which immature T cells clonall...
Elevated d-dimer predicts worse outcomes in hospitalized adults with sickle cell crisis: A real-world multicenter study
Abstract Background: Sickle cell disease (SCD) is marked by recurrent vaso-occlusive crises, which account for the major...