Blood
Articles in this Issue
Overcoming asciminib resistance by targeting compound BCR::ABL1 mutations in chronic myeloid leukemia
Abstract Introduction: Chronic myeloid leukemia (CML) is driven by the BCR::ABL1 fusion gene, which encodes a constituti...
Dynamic monitoring of circulating plasma cells in multiple myeloma: A Prospective multicenter study in China
Abstract Background The minimally invasive nature of circulating plasma cells (CPCs) measurement provides a valuable alternative for real-tim...
Bortezomib-melphalan-prednisone (VMP) +/- daratumumab (DVMP) vs. lenalidomide-dexamethasone (Rd) +/- daratumumab (DRd) in transplant-ineligible real-life multiple myeloma patients: Results from the randomized phase IV real MM trial
Abstract Background. Daratumumab-bortezomib-melphalan-prednisone (DVMP) and daratumumab-lenalidomide-dexamethasone (DRd) are standard treatm...
Ponatinib alleviates CAR-T cell exhaustion and remodels the immune microenvironment: A promising combination strategy for relapsed/refractory b-ALL
Abstract Background Despite CD19-directed chimeric antigen receptor T (CAR-T) therapy achieving remarkable remission rates in relapsed/refra...
SOCS1 in graft CD8+ T cells ameliorates intestinal aGVHD by modulating chemokine-driven monocyte-to-M1 macrophage polarization
Abstract Acute graft-versus-host disease (aGVHD), particularly involving the gastrointestinal tract (GI-GVHD), remains a major complication...
Better discriminative capacity of blast and blast-mol scores in chronic myelomonocytic leukemia (CMML)
Abstract Introduction: Prognostic assessment in chronic myelomonocytic leukemia (CMML) remains a challenge due to the variable clinical cour...
Pharmacokinetics of ferric maltol oral suspension in children and adolescents (1 month to 17 years); A study of iron and maltol metabolism following single and multiple dosing
Abstract Context of research Ferric maltol is an effective oral iron therapy in adults, but its pharmacokinetics (PK) in children are not we...
Polysubstance use and treatment disparities among hospitalized sickle cell disease patients: A nationwide analysis
Abstract Background: Sickle cell disease (SCD) is associated with frequent hospitalizations and significant morbidity. Polysubstance use int...
Trends and disparities in diffuse non-Hodgkin lymphoma-related mortality among u.S. elderly adults: A nationwide analysis (1999-2020) with projections to 2030
Abstract Abstract Background: Diffuse Non-Hodgkin Lymphoma (DNHL) remains a significant contributor to cancer-related mortality among the el...
DNA sequencing outperforms RNA sequencing for comprehensive fusion detection in lymphoma diagnostics
Abstract Background:： Gene fusions constitute essential biomarkers for diagnosing, prognosticating, and guiding therape...
Targeted immunotherapy in children, adolescents, and young adults (CAYA) with newly diagnosed classical Hodgkin lymphoma: A single center experience
Abstract Introduction: Despite excellent survival outcomes, significant chronic health conditions occur among pediatric,...
Allogeneic hematopoietic stem cell transplantation for hematological malignancies using nonmyeloablative fludarabine, cyclophosphamide, 200 centigray total body irradiation, and post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil for graft-versus-host disease prophylaxis is associated with low non-relapse mortality.
Abstract Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers a curative option for a range of hematologic ma...
Temporal trends and forecast of cardiovascular mortality in non-Hodgkin lymphoma patients in the United States: A 1999–2030 population-based analysis
Abstract Background Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of hematologic malignancies that predominantly affects older...
Targeting nucleotide metabolism to enhance ara-c sensitivity in myeloid leukemia associated with down syndrome
Abstract Individuals with Down syndrome (DS) are genetically predisposed to hematologic malignancies, including acute myeloid leukemia (AML)...
Lncrna malnc modulates ATRA-induced transcriptional reprogramming in acute promyelocytic leukemia cells
Abstract Introduction: Acute Myeloid Leukemia (AML) is a heterogeneous malignancy characterized by the clonal expansion of immature myeloid...
Systematic review and meta-analysis of randomized controlled trials on outpatient thromboprophylaxis (OTP) in patients with cancers with khorana score (KS) ≥ 2 receiving chemotherapy
Abstract Introduction: Thrombosis is a major concern for patients with cancers. Cancers with the KS ≥ 2 are highly thrombogenic cancers. Out...
Enhanced efficacy of TRAIL or TRAIL-CD28 chimera armored anti-BCMA CAR T cells in multiple myeloma
Abstract Background: While BCMA-targeted CAR-T cell therapies have shown promising response rates in multiple myeloma (MM), most patients ul...
Obesity is Associated with Higher Risk Disease State and Reduced Overall Survival in Females with MDS
Abstract Myelodysplastic Syndromes (MDS) are amongst the most prevalent hematological malignancies in the elderly, characterized by clonal p...
Pulmonary hypertension as an independent predictor of mortality in hospitalized sickle cell disease patients: A national analysis of comorbidities and outcomes
Abstract Introduction: Sickle cell disease (SCD) is a prevalent inherited hemoglobinopathy characterized by chronic hemolytic anemia and rec...
Context-dependent recruitment of co-factors directs RUNX1 activity in normal and leukemic cells
Abstract Aberrant transcription factor (TF) activity is a major driver of diseases such as leukemia. TFs bind to regulatory elements such as...
A prospective, multicenter, real-world study of glofitamab in Chinese patients with relapsed or refractory large B-cell lymphoma
Abstract Background: Patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) have poor prognoses, particularly those who hav...
Impact of belantamab mafodotin–containing regimens on renal function in patients with Relapsed/Refractory multiple myeloma (RRMM) and mild/moderate renal impairment in the dreamm-7 and dreamm-8 trials
Abstract Introduction: Renal impairment is a common clinical complication in patients with RRMM, and improvement in renal function is associ...
Indirect comparison of bendamustine-rituximab and R-CHOP with rituximab maintenance in first-line treatment of elderly Mantle Cell Lymphoma: Data from the enrich trial
Abstract Background ENRICH is the first randomised open-label phase II/III trial comparing Ibrutinib plus rituximab (IR) with Rituximab-chem...
Cholesterol biosynthesis-related genes reveal new opportunities for risk stratification and treatment in Acute Myeloid Leukemia
Abstract Although genetic and molecular profiling is a well-established method for risk stratification in acute myeloid leukemia (AML), impl...
ARIMA prediction model for mortality caused by Acute Myeloid Leukemia in the United States population up to the year 2050: A CDC wonder database analysis.
Abstract Background: Acute Myeloid Leukemia is one of the leading causes of cancer-related mortality in the United States. In this mortality...