Blood
Articles in this Issue
Evaluating gpt-4 for zero-shot classification of bleeding and clotting events: Can large language models serve as second reviewers?
Abstract Introduction Identifying bleeding and clotting events in the electronic health record (EHR)is critical for quality improvement and...
Sex-related differences in silent cerebral infarction burden among adults with sickle cell disease
Abstract Background: Patients with sickle cell disease (SCD) are at increased risk of both overt strokes and, more commonly, silent cerebral...
Efficacy and safety results from the primary analysis of the pivotal summit trial: Bezuclastinib in adults with non-advanced systemic mastocytosis
Abstract Background: Systemic mastocytosis (SM) comprises a spectrum of subtypes characterized by neoplastic mast cell (MC) infiltration of...
Development of next generation multi-antigen targeting off-the-shelf CAR T cells for conditioning-free treatment of B-cell lymphoma
Abstract Autologous chimeric antigen receptor (CAR) T-cell therapy has had tremendous success in the treatment of hematological malignancies...
Efficacy and safety of chidamide and Bruton tyrosine kinase inhibitors combination therapy in relapsed/refractory diffuse large B-cell lymphoma
Abstract Background: Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) shows poor clinical outcomes, particularly in patient...
Multicenter real-world experience of belumosudil treatment in heavily pretreated patients with steroid-refractory chronic graft-versus-host disease: Clinical outcomes and risk factor analysis for failure-free survival.
Abstract Introduction Belumosudil (BEL), a selective Rho-associated coiled-coil kinase 2 (ROCK2) inhibitor, has shown significant clinical a...
The combination of ruxolitinib and the CDK4/6 inhibitor abemaciclib demonstrates safety and efficacy in previously treated myelofibrosis patients: Results of A phase I study
Abstract Introduction: Janus kinase (JAK) inhibitors such as ruxolitinib (RUX) are a standard of care for myelofibrosis (MF) patients with sy...
Efficacy and safety of daratumumab plus carfilzomib-based induction/consolidation/maintenance therapy with autologous stem cell transplantation in transplant-eligible ultra high-risk newly diagnosed multiple myeloma: Preliminary results
Abstract Background: Despite therapeutic advances, ultra-high-risk (UHiR) newly diagnosed multiple myeloma (NDMM) patients, experience signi...
A risk-based scoring approach to individualize prophylaxis in patients with Hemophilia A: Results from the predict study
Abstract To date, there is no consensus on what constitutes optimal prophylaxis in hemophilia A. In the absence of pharmacokinetic data, FVI...
Next generation sequencing profiling of pediatric Acute Myeloid Leukemia reveals distinct genetic landscapes across cytogenetic subgroups
Abstract Next-generation sequencing (NGS) transformed the molecular diagnosis of pediatric acute myeloid leukemia (AML), enabling simultaneo...
Examining TP53-mutated plasma cell disorders across the disease spectrum using broad next generation sequencing
Abstract TP53 is the most frequently mutated gene in human cancer. Loss-of-function mutations or deletions of chromosome 17p are strongly as...
First promising results in younger adult patients (<65 yrs) with newly diagnosed ph/BCR::ABL positive ALL treated within the randomized GMALL evolve trial
Abstract Outcomes in younger patients (pts) with Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ ALL) have improved by using tyrosin...
Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia
Abstract Background: NPM1-mutant acute myeloid leukemia (AML) is the most common molecular subtype of AML and generally responds well to int...
A comprehensive geriatric assessment to evaluate individual frailty status and quality of life in patients with Waldenström macroglobulinemia: A prospective italian study
Abstract Background: Frailty in Waldenström's Macroglobulinemia (WM) is poorly-defined and hard to assess objectively, despite its impact on...
Impact of graft versus host disease prophylaxis with post transplant cyclophosphamide on the prognostic value of HCT-CI
Abstract Background: The hematopoietic cell transplantation specific comorbidity index (HCT-CI) is a crucial validated prognostic tool used...
Renin-angiotensin-aldosterone system inhibitors exacerbate anemia in sickle cell disease
Abstract Introduction: Renin-angiotensin-aldosterone system inhibitors (RAASi) are recommended by American Society of Hematology and Nationa...
Phenotypic evolution of circulating tumor plasma cells across MGUS, SMM and multiple myeloma
Abstract Introduction. Circulating tumor plasma cells (CTPCs) have emerged as a powerful diagnostic and prognostic tool in multiple myeloma (...
Priming of bone marrow stromal cells with the epigenetic modifier decitabine overcomes stroma-mediated resistance to bortezomib in multiple myeloma cells.
Abstract Title of the project Priming of bone marrow stromal cells with the epigenetic modifier decitabine overcomes stroma-mediated resista...
Undiagnosed patent foramen ovale with bi-atrial thrombus in transit: A case of pulmonary embolism and refractory hypoxia
Abstract Background: Pulmonary embolism (PE) is a potentially life-threatening condition that can cause hypoxia, hemodynamic instability, an...
Nanopore sequencing-based profiling of circular RNAs in multiple myeloma uncovers circNFATC3 as a promising prognostic biomarker
Abstract Introduction: Circular RNAs (circRNAs) are a distinct class of non-coding RNAs with regulatory roles and emerging value as non-inva...
Sipa1 loss in host niche boosts anti-AML immune response
Abstract Background: Signal-induced proliferation-associated gene 1 (Sipa1), a RAP1 GTPase-activating protein, is expressed in both hematopo...
Single versus double “7+3” induction with 60 versus 90 mg/m2 daunorubicin in newly diagnosed AML: Does it matter for NPM1 MRD?
Abstract Introduction The randomized-controlled SAL DaunoDouble trial (NCT02140242) showed no significant differences in complete remission...
Research on allogeneic CAR-T.BiTE cells targeting CLL-1/siglec-6 for the treatment of Acute Myeloid Leukemia
Abstract Cellular immunotherapy has transformed the treatment of hematologic malignancies, yet acute myeloid leukemia (AML) remains stubborn...
This is a title in sentence case:early intrathecal dexamethasone and methotrexate as an effective approach for immune effector cell-associated neurotoxicity syndrome after CAR-T cell therapies
Abstract Introduction：Chimeric antigen receptor T (CAR-T) cell therapies have demonstrated remarkable success in treating relapsed and refr...
Genome-wide investigation of differentially expressed alternative splicing and RNA-binding protein genes association with AML drug resistance
Abstract Background Acute myeloid leukaemia (AML) is a malignancy of the haematopoietic system with extremely high mortality. Current AML th...