Blood
Articles in this Issue
Disrupting the PA2G4-NPM1 axis induces nucleolar stress in NPM1c AML
Abstract Targeting NPM1, the most common abnormality in acute myeloid leukemia (AML), is still a significant challenge. Numerous efforts hav...
Increased prevalence of alternative splicing in core-cohesin subunit mutated AML as compared to STAG2 mutated AML
Abstract Cohesin is a protein complex that organizes chromatin structure through DNA loop-extrusion. Subunits of the cohesin complex are rec...
Chromothripsis drives high-risk multiple myeloma by copy number abnormalities and rewiring the epigenome to activate oncogenic programs.
Abstract Background: Chromothripsis, a catastrophic event of chromosomal shattering and reassembly, is a key driver of oncogenesis and is as...
Characteristics of women who have beta thalassemia discovered during pregnancy
Abstract Background: Anemia is common during pregnancy, usually attributed to iron deficiency. Some pregnant women with anemia are found to...
RAS mutations negate the favorable impact of NPM1 in older patients with newly diagnosed Acute Myeloid Leukemia treated with ven/HMA
Abstract Background: Activating RAS mutations play an important role in the pathogenesis of acute myeloid leukemia (AML) and occur in approx...
Acquired Bruton's tyrosine kinase mutations in patients treated on the ibrutinib and rituximab, ibrutinib alone, and ibrutinib and venetoclax arms of the national multi-centre Phase III FLAIR study in previously untreated CLL patients
Abstract Background: The FLAIR trial confirmed that ibrutinib alone (I), ibrutinib and rituximab (IR), and MRD-directed ibrutinib and veneto...
Pembrolizumab (Pembro) plus R-CHOP is efficacious as first-line therapy for primary mediastinal B-cell lymphoma (PMBL) with high rates of ctdna negativity – interim efficacy analysis of the ALLG-Pacific (NHL35) trial
Abstract Introduction: PMBL comprises 10% of diffuse large B-cell lymphoma, primarily affecting young adults. Chemoimmunotherapy is effectiv...
HbSS mice accumulate mitochondrial DNA mutations at a significantly higher rate than HbAA and HbAS mice
Abstract Introduction: Acquired mitochondrial DNA mutations (mtDNA heteroplasmy) and changes in mtDNA copy number (mtDNA-CN) are indicators...
Anti-PF4 antibodies are a potential mediator of antisense oligonucleotide (ASO)-induced thrombocytopenia.
Abstract Introduction: Antisense oligonucleotides (ASOs) technology has emerged as a transformative approach in molecular therapeutics, offe...
Intratumoral B cell diversity in follicular lymphoma revealed by single-cell paired transcriptome and BCR sequencing
Abstract Background: Follicular lymphoma (FL) is a germinal center–derived B cell malignancy characterized by the clonal...
Real-world comparative outcomes of CAR-T cell therapy versus bispecific antibodies in patients with diffuse large B-cell lymphoma
Abstract Introduction: The emergence of novel immunotherapies and cellular therapies has transformed the treatment landscape for hematologic...
Pembrolizumab plus gemcitabine, vinorelbine, and liposomal doxorubicin as second-line therapy in relapsed or refractory Hodgkin lymphoma: 5-year update of a multicenter, Phase 2 trial
Abstract Background: The incorporation of novel agents such as brentuximab vedotin (BV) and immune checkpoint blockade (ICB) into salvage th...
Pulmonary hypertension on right heart catheterization is associated with worse progression-free survival in patients with myeloproliferative neoplasms
Abstract Introduction: Pulmonary hypertension (PH) is associated with Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs. I...
Kpg-818, a novel cereblon (CRBN) modulator, in patients with hematological malignancies: Results of a Phase 1, open-label, multiple ascending dose study
Abstract Introduction: KPG-818 is a novel CRL4-CRBN E3 ubiquitin ligase modulator that binds to CRBN with high affinity and leads to rapid a...
Inpatient outcomes of diffuse large B-cell lymphoma: Racial and socioeconomic disparities in a nationally representative sample
Abstract Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL), accounting for 25-30%...
Real-world insights into ATRA-based maintenance therapy and prognostic markers of relapse in acute promyelocytic leukemia
Abstract Real-world insights into ATRA-based maintenance therapy and prognostic markers of relapse in acute promyelocytic leukemia...
In silico structural biology studies inform the identification of “druggable” pockets in previously understudied dependencies with tumor type/lineage-selective roles.
Abstract We previously applied genome-scale CRISPR knockout studies in a range of cell lines to identify genes that are more potent and recu...
Characterization of a population with newly diagnosed standard risk multiple myeloma by the 2025 ims/IMWG definition with exceptional long-term outcomes after fixed duration therapy
Abstract Introduction: Multiple myeloma has been regarded as incurable, with steady and sizeable risk of progression even for patients withou...
Epigenetically driven upregulation of immunoproteasome component PSMB8 characterizes diffuse large B-cell lymphoma (DLBCL) with inflammatory microenvironment in African ancestry patients
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most prevalent and biologically heterogenous hematologic malignancy, representing appr...
Cladribine-based regimens for Relapsed/Refractory Acute Myeloid Leukemia – a real-world multicenter retrospective study
Abstract Background: Relapsed/refractory (R/R) AML represents an unmet medical need requiring novel salvage approaches t...
Ciltacabtagene autoleucel out-of-specification manufacturing outcomes improve with earlier lines of therapy
Abstract Introduction: Ciltacabtagene autoleucel (cilta-cel) is a B-cell maturation antigen–directed chimeric antigen receptor-T cell therap...
Early-onset T-cell large granular lymphocytic leukemia in a 24-year-old woman: A rare case with confirmed clonality and immune-mediated cytopenias
Abstract T-cell large granular lymphocytic leukemia (T-LGLL) is an indolent clonal lymphoproliferative disorder that primarily affects indiv...
Arginine deprivation activates immunogenic cell death and enhances anti-tumor immunity in diffuse large B-cell lymphoma
Abstract L-Arginine, a conditionally essential amino acid, plays critical physiological roles via pathways including the urea cycle. Buildin...
Dietary saturated fatty acid composition alters the platelet lipid profile and promotes platelet hyperreactivity
Abstract Background: Platelets exhibit a unique lipid composition characterized by increased polyunsaturated fatty acids (PUFAs) and decreas...
An open-label, Phase 2 study of dapolsertib (MEN1703, SEL24) as monotherapy and in combination with glofitamab in patients with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma
Abstract Aggressive B-cell non-Hodgkin lymphomas represent a clinically heterogeneous group of malignancies characterized by rapid progressi...