Blood
Articles in this Issue
Incidence patterns of Acute Myeloid Leukemia in the United States from 1999 to 2021: Analysis by age, sex, and race/ethnicity
Abstract Background: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with variable incidence by age...
NQO1 modulates CD38 surface expression in multiple myeloma
Abstract Introduction: The efficacy of immunotherapies such as monoclonal antibodies (mAbs), CAR T cells, and bispecific...
Poor nutritional intake prior to allogeneic hematopoietic cell transplantation is associated with higher incidence of lower-gastrointestinal graft-versus-host disease
Abstract Introduction. Nutritional intake during allogeneic hematopoietic cell transplantation (allo-HCT) may influence clinical outcomes an...
Stability of ADAMTS13 activity in liquid plasma and its clinical application in therapeutic plasma exchange for thrombotic thrombocytopenic purpura
Abstract Background Liquid plasma (LP) is a never-frozen product stored at 1-6 °C with a shelf-life of 21–26 days and is often used as a bri...
Indirect treatment comparison of novel JAK2 Inhibitor OB756 versus ruxolitinib in polycythaemia vera with splenomegaly
Abstract Introduction:JAK inhibitors (JAKi) are crucial in managing polycythaemia vera (PV) by improving symptoms and reducing spleen volume...
Social determinants of health and emergency department utilization in sickle cell disease: A systematic review and meta-analysis
Abstract Introduction Social determinants of health (SDoH), such as economic hardship, housing insecurity, and healthcare access, drive outc...
Reduction of iron overload in hereditary hemochromatosis model mice by presence of iron metabolism mutant
Abstract Hereditary Hemochromatosis (HH) is an iron overloading disease for which repeated phlebotomy, followed by maintenance phlebotomy, a...
Low levels of enhancer of zeste homolog 2 (EZH2) protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia.
Abstract INTRODUCTION: Mutations in the Enhancer of Zeste Homolog 2(EZH2) occur in ~ 4% of Acute Myelogenous Leukemia (AML) cases, and confe...
Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, shows high clinical activity and tolerable safety in patients with Waldenström macroglobulinemia: Updated results from an ongoing Phase 1a/b study
Abstract Introduction: The B-cell receptor signaling pathway mediated by BTK is a validated therapeutic target in Waldenström macroglobuline...
Hyperfractionated cyclophosphamide, bortezomib and dexamethasone for initial treatment of newly diagnosed multiple myeloma with renal dysfunction
Abstract Introduction: Renal injury due to light chain cast nephropathy is a defining feature of multiple myeloma. A prospective study previo...
Real-world descriptive analysis of the use of bispecific t cell engagers (BiTEs) in the treatment of hematological malignancies in Qatar: A state-wide retrospective cohort study
Abstract Introduction One of the most promising modalities in immunotherapy includes Bispecific T cell Engagers (BiTEs),...
Hyperuricemia modifies multiple myeloma pathobiology and modulates conventional, novel, and immuno-oncology drug sensitivity
Abstract Background: Renal impairment is seen in up to 50% or more of patients with multiple myeloma and has been linked to inferior short-...
Integrated clinico-biological profiling identifies a high-risk epigenetic signature in Mantle Cell Lymphoma: A lysa study
Abstract Introduction: Immunochemotherapy remains the cornerstone of treatment for Mantle Cell Lymphoma (MCL). However,...
Mortality trends of sepsis in patients with leukemia in the United States (1999–2020): A CDC wonder database analysis
Abstract Background: Patients with leukemia are more likely to develop sepsis as a result of disease-related immunosuppression and cytotoxic...
Clonal evolution of pediatric Acute Myeloid Leukemia
Abstract Relapse remains the major cause of mortality in pediatric acute myeloid leukemia (AML). Although initiating driver alterations are...
Whole genome sequencing uncovers novel BCR::ABL1 breakpoints and variants in leukemia: Implications for personalized medicine
Abstract Background: The BCR::ABL1 fusion gene is a hallmark of chronic myeloid leukemia (CML) and is also present in a subset of acute lymp...
Lisocabtagene maraleucel (liso-cel) versus standard of care (SOC) for second-line relapsed or refractory large B-cell lymphoma (LBCL): First Results from long-term follow-up of TRANSFORM
Abstract Introduction: Liso-cel is an autologous, CD19-directed, 4-1BB CAR T cell product. TRANSFORM (NCT03575351) is a global, randomized, o...
JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells.
Abstract Retrotransposon expression must be tightly controlled, particularly in long-lived multipotent stem cells, to prevent deleterious co...
Survival and gvhd disparities in UAE patients undergoing allo-HSCT abroad: A multicenter benchmark study
Abstract Background: Until 2022, the United Arab Emirates (UAE) lacked in-country allogenic hematopoietic stem cell transplant (allo-HSCT) s...
Outcomes of plasmapheresis in patients with HLH: A nationwide analysis from 2016–2022
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening hyperinflammatory syndrome characterized by unc...
Elevation of fetal hemoglobin is a biomarker for response to decitabine in AML: Results of the AML21 randomized phase III trial of the EORTC leukemia group, gimema and german MDS study group
Abstract Introduction DNA-hypomethylating agents (HMA) have become standard treatment for patients (pts) with acute myel...
S2005: A phase II randomized study comparing ibrutinib and rituximab (IR) VS. venetoclax and rituximab (VR) in previously untreated waldenstrom's macroglobulinemia (WM) / lymphoplasmacytic lymphoma (LPL).
Abstract Background and Significance: Waldenström's Macroglobulinemia (WM) is an indolent B cell disorder characterized by proliferation of...
Efficacy of single-agent subcutaneous blinatumomab in adults with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL): Results from a phase 1/2 dose expansion study with extended follow-up
Abstract Introduction: Blinatumomab, a BiTE® (bispecific T-cell engager) molecule, is an effective treatment for relapsed or refractory (R/R...
Increased prevalence of anemia among recently immigrated female South Asian college students: A cross-sectional study from three primary care clinics in a college town
Abstract Background: Anemia is a major health concern among women of reproductive age, particularly in South Asia, where nutritional deficie...
Volume and nature of classical hematology outpatient consults within a national cancer institute-designated comprehensive cancer center
Abstract Introduction A 2017 survey by the American Society of Hematology found a widespread perceived shortage of classical hematologists i...