Blood
Articles in this Issue
High neutrophil-to-lymphocyte ratio does not predict MGUS to myeloma progression but is associated with worse survival as a marker of global inflammation
Abstract BACKGROUND Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal plasma cell disor...
Cost savings across bone marrow testing strategies in persons with suspected monoclonal gammopathy of undetermined significance
Abstract Introduction: Monoclonal gammopathy of undetermined significance (MGUS) affects over 2 million individuals aged ≥70 in the US. Earl...
CAR-hematotox score for predicting outcomes among myeloma patients receiving BCMA targeting CART constructs (ide-cel and cilta-cel)
Abstract Background CAR-HEMATOTOX score, a cumulative score of key independent laboratory variables, is a clinical surrogate of bone marrow r...
Measles vaccine-induced sero-protection among children with sickle cell anemia
Abstract Introduction: Measles is a highly contagious and vaccine-preventable disease with increasing infection rates across the United Stat...
First results of exagamglogene autotemcel in pediatric patients aged 5-11 years with transfusion-dependent β-thalassemia or sickle cell disease with recurrent severe vaso-occlusive crises
Abstract Background: Exagamglogene autotemcel (exa-cel) is a one-time, autologous cell therapy that reactivates fetal hemoglobin (HbF) synth...
Comparison of outcomes in pediatric patients with acute leukemia undergoing allogeneic HLA-haploidentical hematopoietic stem cell transplantation (HSCT) after in vitro a/b T- and CD19-cell depletion or In Vivo administration of post-transplant cyclophosphamide: An EBMT pediatric working party study
Abstract Background HLA-haploidentical relatives are increasingly used to transplant children with acute leukemia (AL) requiring an allograf...
Efficacy and safety analysis of CAR-T cell therapy in relapsed/refractory diffuse large B-cell lymphoma after failure of bispecific antibody treatment
Abstract Background: Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who fail bispecific antibody (BsAb) therapy...
A novel method for molecular subtyping diffuse-large B-cell lymphoma using whole-exome sequencing
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive form of non-Hodgkin lymphoma, with 30-40% of case...
Chromodomain helicase DNA binding protein CHD2 interacts with TET2 and regulates lineage defining transcription in hematopoietic stem and progenitor cells
Abstract Introduction. TET2 mutations (TET2MT) are among the most frequent somatic lesions in myeloid malignancies, found at ~30% in MDS/AML...
The burden of hematological malignancies in Latin America and the Caribbean: A 30-year global burden of disease analysis
Abstract Background Hematologic malignancies (HM) such as leukemia, non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma (MM)...
Semaphorin 4D and interleukin 1beta-complement cascade axis are key drivers of disease progression in multiple myeloma
Abstract Background and aims: Myeloma bone disease (MBD) is a common and clinically significant manifestation, observed in most patients at t...
Maintenance with hypomethylating agent + venetoclax after intensive induction chemotherapy in patients with newly diagnosed Acute Myeloid Leukemia
Abstract Background Consolidative therapy with high/intermediate-dose cytarabine is standard practice for fit patients w...
Unbiased in-depth surfaceome profiling of Acute Myeloid Leukemia reveals novel immunotherapy targets beyond canonical membrane proteins
Abstract Background Despite recent therapeutic advances, 5-year survival for AML in adults remains ~35% (SEER estimate). Immunotherapies hav...
Trends in mortality and comorbidity of type 2 diabetes mellitus among u.S. adultswith multiple myeloma: A CDC wonder-based analysis, 1999–2023
Abstract Background : Type 2 diabetes and Multiple myeloma are becoming a growing cause of worry among aging populations...
External validation of an online predictive model for myelodysplastic syndrome
Abstract Background: Single-lineage cytopenia is highly prevalent in the elderly population, with common causes including nutritional defici...
Genome-wide CRISPR-Cas9 screen reveals novel ruxolitinib-resistance targets in myeloproliferative neoplasms
Abstract Introduction: Philadelphia-negative myeloproliferative neoplasms (MPNs) are a group of diseases, including primary myelofibrosis (P...
FLP-R: A clinical prediction model for follicular lymphoma Prognosis in the Relapsed/refractory setting
Abstract Background: Prognostication for patients with non-transformed relapsed/refractory (R/R) follicular lymphoma (FL) is not well define...
Comparative performance of clinical versus genomic machine learning prognostic models in AML: A prisma-guided systematic review and meta-analysis
Abstract Background: Machine learning and deep learning models are increasingly used to refine prognosis in acute myeloid leukemia, but clin...
Multimodal assessment of chronic myelomonocytic leukemia with extramedullary involvement reveals RAS pathway activation, adverse outcomes and epithelial-mesenchymal transition
Abstract Background: Extramedullary disease (EMD) in chronic myelomonocytic leukemia (CMML) patients (pts) remains poorly characterized with...
Unsupervised clustering of RNA sequencing data identifies a novel XBP1-mutated subtype of B-cell acute lymphoblastic leukemia (B-ALL)
Abstract 1. Research Objectives :With the application of RNA sequencing (RNA-seq) in B-ALL, the diagnosis of B-ALL has entered the era of pr...
Cell-free DNA (cfDNA) and plasma proteomics reveal inflammatory heterogeneity in vaso-occlusive crises in sickle cell disease (SCD).
Abstract Background: SCD is characterized by chronic hemolytic anemia and recurrent vaso-occlusive crises (VOCs), which are a leading cause...
The platelet variability index tool to determine the likelihood of immune thrombocytopenia (ITP): User testing and tool refinement
Abstract Introduction The diagnosis of immune thrombocytopenia (ITP) is challenging due to the lack of a reliable diagno...
Temporal trends and future projections of sepsis mortality in leukemia: A nationwide analysis of demographic and geographic disparities (1999–2030)
Abstract Background: Leukemia is a hematologic malignancy characterized by the uncontrolled proliferation of leukocytes, and it is broadly c...
High-dimensional profiling reveals predominant depletion of NK cell effector phenotypes in relapsed/refractory multiple myeloma patients treated with anti-CD38 therapy
Abstract Background: Anti-CD38 monoclonal antibodies (mAbs) have become a standard part of multiple myeloma (MM) therapy. Their activity is...
PARP inhibition by talazoparib results in leukemia cell death via induction of myeloid differentiation
Abstract Background: Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy characterized by the uncontrolled proliferation o...