Blood
Articles in this Issue
The role and modulation of the inflammasome in the sickle cell disease oral phenotype in female mice
Abstract Sickle Cell Disease (SCD) is the most common inherited blood disorder affecting millions worldwide. SCD is caused by a genetic muta...
Outcomes of immune thrombocytopenia hospitalizations in patients with diabetes mellitus
Abstract Background: Corticosteroid therapy is the first-line treatment of immune thrombocytopenia (ITP) with moderate to severe thrombocyto...
Short survival with BCMA and GPRC5D dual antigen exposed relapsed myeloma- an international myeloma working group immunotherapy database analysis
Abstract Background: BCMA- and GPRC5D-targeting immunotherapies including CART cell therapy and Bispecific antibodies ar...
Increased serum h-ferritin and its imbalance with l-ferritin distinguish hemophagocytic lymphohistiocytosis among critically ill patients with hyperferritinemia.
Abstract Serum Ferritin is a sensitive screening parameter to diagnose hemophagocytic lymphohistiocytosis (HLH) in critically ill patients b...
Inhibition of nicotinamide metabolism by the novel NAMPT inhibitor OT-82 potentiates venetoclax in paediatric and adult acute myeloid leukaemia models
Abstract Introduction While the survival rate of paediatric acute lymphoblastic leukaemia (ALL) has increased up to 90%, the prognosis for bo...
Long-term outcomes of dexamethasone prophylaxis after axicabtagene ciloleucel for non-Hodgkin lymphoma: A single-center retrospective study
Abstract Background: A small cohort of patients receiving prophylactic dexamethasone (dex) after axicabtagene ciloleucel (axi-cel) within ZU...
Identifying educational and resource needs of general internal medicine physicians in sickle cell disease management.
Abstract Background: Sickle cell disease (SCD) presents with a wide spectrum of acute and chronic complications that require timely recognit...
Prognostic factors influencing relapse and survival of childhood acute lymphoblastic leukemia with the ALL-BFM IC 2009 protocol
Abstract Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, remaining the fourth leading cause of dea...
Comparing the safety of direct oral anticoagulants vs. low-molecular-weight heparin in patients with thrombocytopenia and venous thromboembolism
Abstract Introduction: Balancing the safety and efficacy of anticoagulation (AC) for venous thromboembolism (VTE) among patients with thromb...
Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial
Abstract Background: ACS occurs in up to 20% of hospitalized patients with SCD-VOE, often prolonging and complicating hospital stay. Despite...
CD7-negative T cell immune reconstitution after CD7-targted CAR-T cell therapy
Abstract Background Recently, CD7-targeted CAR-T cells have shown both safety and efficacy in early-stage clinical studi...
Role in of primary VTE prophylaxis in pediatric patients in hospitalized and critically ill settings: A systematic review and meta-analysis
Abstract Venous thromboembolism (VTE) is a major cause of morbidity in hospitalized and critically ill children . Currently there is a lack o...
Multiarm Phase I study of the cyclin dependent kinase (CDK4/6) inhibitor palbociclib in combination for patients with relapsed and refractory acute leukemias
Abstract Background Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression in proliferating cells and are commonly dys...
ATM dysfunction across ataxia telangiectasia and leukemias: A systematic review of genetic drivers and functional impact
Abstract Introduction Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder caused by mutations in the ATM gene. Both germline a...
Real-world data of lisocabtagene maraleucel as second line therapy for patients with large B-cell lymphoma: Updated Results of the french descar-T registry by lysa
Abstract Introduction: Lisocabtagene maraleucel (liso-cel) has demonstrated superior effectiveness as second-line (2L) t...
Bone marrow spatial architecture predicts response duration in smoldering multiple myeloma patients receiving checkpoint inhibitor therapy
Abstract Introduction While spatial analysis has identified immune features predicting immunotherapy response in solid tumors, spatial infor...
Gene-modified iPSC-derived MSCs convert immunosuppressive tumor microenvironments (TMEs) into distinct Pro-inflammatory tmes
Abstract Background: Immunotherapy has transformed cancer care, inducing durable responses in both hematologic and solid tumors. Despite the...
Phase II study of clinical efficacy of venetoclax in combination with azacitidine in patients with therapy related myelodysplastic syndrome (t-MDS)
Abstract Introduction: Therapy related-MDS (tMDS), a known sequalae of genotoxic therapies, is a highly aggressive form of MDS accounting fo...
Avatrombopag improves platelet engraftment after haploidentical hematopoietic stem cell transplantation: A randomized, double-blind, multicenter, placebo-controlled trial
Abstract Introduction: Delayed platelet (PLT) recovery is a common complication following haploidentical hematopoietic s...
A review and analysis of reported global blood and marrow transplantation costs in comparison to macroeconomic factors including gross national income per capita and out-of-pocket health expenditures
Abstract Introduction: Despite increasing blood and marrow transplantation activity globally throughout the last few decades, regional and e...
High fructose diet exacerbates acute GVHD through microbiota dysbiosis and HIF-1α–mediated macrophage activation
Abstract Background Acute graft-versus-host disease (aGVHD) is a life-threatening complication following allogeneic hematopoietic stem cell t...
Splenic dysfunction in young children with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is a hemoglobinopathy characterized by sickle cell shaped deformation of red blood cells le...
Respiratory viral infections are a significant cause of morbidity during long-term follow-up after CAR T cell therapy: Analysis of 445 episodes
Abstract Background: Infectious complications are the leading cause of non-relapse mortality following CAR-T cell therapy. Respiratory viral...
Psychiatric comorbidities and the mortality paradox in sickle cell disease: A national inpatient analysis
Abstract Background: Sickle cell disease (SCD) is a genetic hemoglobinopathy which causes recurrent hospitalization. Psychiatric comorbiditi...
MYC partners with kinase-independent PIM2 at key promoters in multiple myeloma
Abstract Introduction: Multiple Myeloma (MM) is an incurable hematological malignancy characterized by abnormal plasma cell proliferation in...