Blood
Articles in this Issue
Miscalibration of venous thromboembolic risk assessment models across race and ethnicity in medical patients: A cross-model analysis, correction strategy and potential mediators
Abstract Background: Hospital-associated venous thromboembolism (VTE) affects 350,000 US patients annually and is the leading cause of preve...
Expression of the erythroid controller of systemic iron homeostasis erythroferrone is cis-regulated
Abstract Erythroferrone (ERFE) is secreted from erythroblasts in response to increased erythropoiesis to suppress hepcidin, enabling enhance...
Poor prognosis of immunosuppressive therapy in patients with bone marrow failure-related germline mutations combined with BCOR/L1 Mutations
Abstract Introduction Non-severe aplastic anemia (NSAA) shows varied treatment responses and outcomes. While clonal mutations' role in disea...
Fapi PET/CT as an innovative imaging tool for monitoring bone marrow fibrosis and treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation
Abstract Background: Myelofibrosis (MF) is a clonal myeloproliferative neoplasm, characterized by progressive bone marrow fibrosis driven by...
A phase 1/2 study of GB3226, a novel dual inhibitor of ENL-yeats and FLT3, in patients with relapsed/refractory Acute Myeloid Leukemia
Abstract Background: Acute myeloid leukemia (AML) remains a formidable challenge in hematology, particularly for patients with relapsed or r...
KMT2Ar, but not other high-risk genetics, adversely impacts outcomes in adult patients with relapsed/refractory (R/R) Philadelphia chromosome negative B-cell acute lymphoblastic leukemia (B-ALL) treated with brexucabtagene autoleucel (Brexu-cel)
Abstract Introduction: Brexu-cel is a highly effective treatment for R/R B-ALL, with complete responses achieved in 71%...
Functional investigation into NK cells identifies salt-inducible kinases as novel therapeutic targets against NK malignancies
Abstract Background: Natural Killer (NK) cells are innate lymphoid cells that play critical roles in anti-tumor and anti-viral immunity. How...
Do patients with classic Hodgkin's lymphoma treated with ABVD in low-middle income countries have a higher risk of neutropenia/febrile neutropenia without G-CSF support? a single-center retrospective study
Abstract Introduction: Patients with Hodgkin lymphoma (cHL) who receive adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemother...
Association of duffy antigen receptor for chemokines with clinical conditions: A scoping review
Abstract Introduction: The Duffy antigen receptor for chemokines (ACKR1) is found on erythrocytes and appears to function as a chemokine sin...
Global immunopeptidome remodeling favors piga mutant clones in bone marrow failure
Abstract The basis of PNH immune privilege remains elusive. Various models have been proposed, each consistent with some but not all clinica...
C-CBL mutations affecting residue 371 confer dismal prognosis in MDS and CMML
Abstract In myeloid neoplasm (MN), c-CBL missense mutations affecting the linker region and zinc finger domains (LR/ZF, 352-420 residues) im...
Rates of inhibitor development and immune tolerance in children with severe Hemophilia A on emicizumab prophylaxis
Abstract Introduction: Congenital hemophilia A (HA) is a genetically inherited bleeding disorder caused by pathologic variants in the F8 gen...
Relationship between KIT inhibition by bezuclastinib and effects on disease burden in mouse models of systemic mastocytosis
Abstract Background: Nonadvanced Systemic Mastocytosis (NonAdvSM) is primarily driven by activating mutations in the KIT proto-oncogene, wit...
Optimizing PNH treatment with the complement inhibitor pegcetacoplan: A case report
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, serious hematologic disorder characterized primarily b...
Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis
Abstract Hematopoietic stem cells (HSCs) are multipotent cells that can give rise to all blood cell types. In leukemia, HSCs are often the c...
A scoring system for epstein-barr reativation after hematopoietic stem cell transplantation
Abstract Objective: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for hematological malignancies....
Haploidentical hematopoietic cell transplantation (Haplo-HCT) using ex vivo TCR-αβ–Depleted grafts and upfront memory T-cell add-back mitigates the negative impact of pre-transplant measurable residual disease (MRD) in adults with Acute Myeloid Leukemia (AML) and acute lymphoblastic leukemia (ALL) compared to matched related and unrelated donor transplantation
Abstract Background Previous studies have shown that in patients receiving allogeneic hematopoietic cell transplantation (HCT) from either a...
Same outcomes, different odds: Socioeconomic disparities in PMBCL care across u.S. cancer centers
Abstract Background: Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct and aggressive subtype of large B-cell lymphoma that ar...
Multimodal single-cell and spatial analyses reveal a distinct immune ecosystem in pediatric classic Hodgkin lymphoma
Abstract Introduction: Classic Hodgkin lymphoma (CHL) is unique among most malignancies as the malignant Hodgkin and Reed–Sternberg (HRS) cel...
A clinical study on the Efficacy and safety of luspatercept in Chinese patients with non-transfusion-dependent β-thalassemia
Abstract Background: β-thalassemia is a hereditary anemia caused by insufficient hemoglobin production due to reduced or complete absence of...
BI-1808, a tumor necrosis factor receptor 2 (TNFR2) blocker/depleter, showing promising efficacy in T cell lymphoma patients
Abstract Background: T-cell lymphomas (TCL) make up about 10-15% of all Non-Hodgkin's Lymphomas (NHLs), with peripheral T-cell lymphoma (PTC...
Metabolic conditioning for enhanced CAR T cell function
Abstract Introduction Durable benefits in adoptive immunotherapies are often linked to metabolic reprogramming, differentiation states, and...
Autologous hematopoietic stem cell transplantation followed by CD19/CD22 dual-target CAR-T therapy for refractory or relapsed burkitt lymphoma
Abstract Background Relapsed and refractory (R/R) Burkitt's lymphoma is characterized by its aggressive nature and poor prognosis. Autologou...
Incidence, risk factors, and survival impact of secondary myelofibrosis in patients with myeloproliferative neoplasms in the real world: A nested case-control study
Abstract Myeloproliferative neoplasms (MPN) are a group of diseases characterized by clonal proliferation of hematopoietic stem cells in the...
Gut colonization with MDR gram negative organisms and its impact on bacteremia and sepsis development among children with hematological malignancies
Abstract Background: Gut colonization with multidrug-resistant organisms (MDROs) is a well-established risk factor for b...